CAS 1263-89-4: Sulfato de paromomicina
Descripción:
Sulfato de paromomicina es un antibiótico aminoglucósido que se utiliza principalmente para tratar infecciones causadas por ciertos tipos de bacterias, particularmente en casos de amebiasis intestinal y leishmaniasis. Se deriva de la bacteria Streptomyces griseus y funciona inhibiendo la síntesis de proteínas en microorganismos susceptibles. El compuesto se caracteriza por su capacidad para unirse a la subunidad ribosomal 30S, lo que lleva a una lectura errónea del ARNm y, en última instancia, interrumpe el crecimiento bacteriano. La paromomicina se administra típicamente por vía oral o parenteral, dependiendo de la infección que se esté tratando. Se conoce por su toxicidad relativamente baja en comparación con otros aminoglucósidos, aunque aún puede causar efectos secundarios como trastornos gastrointestinales y nefrotoxicidad en algunos casos. La forma sulfato mejora su solubilidad en agua, lo que la hace adecuada para diversas formulaciones. La paromomicina también se está investigando por su posible uso en el tratamiento de infecciones multirresistentes, destacando su importancia en el campo de la terapia antimicrobiana.
Fórmula:C23H45N5O14·xH2O4S
InChI:InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
Clave InChI:InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N
SMILES:S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N
Sinónimos:- (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
- (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
- (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
- 1600 Antibiotic
- 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
- Aminosidin sulfate
- Aminosidin sulphate
- Aminosidine Sulphate
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Encontrado 16 productos.
Paromomycin Sulfate
CAS:Aminoglycoside antibioticsFórmula:C23H45N5O14·xH2SO4Forma y color:White Off-White Light Yellow PowderPeso molecular:615.2963Paromomycin sulfate
CAS:Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.Fórmula:C23H45N5O14·xH2SO4Pureza:≥675Μg/Mg(On Dried Basis)Forma y color:Yellow PowderPeso molecular:615.63 g/molParomomycin Sulfate
CAS:Stability Hygroscopic Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis. References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);Fórmula:C23H45N5O14·H2O4SForma y color:NeatPeso molecular:713.71Paromomycin sulfate
CAS:Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C23H47N5O18SForma y color:White to pale cream to pale yellow, PowderPeso molecular:713.71Paromomycin Sulfate
CAS:Fórmula:C23H45N5O14·xH2SO4Pureza:>92.0%(HPLC)Forma y color:White to Almost white powder to crystalParomomycin sulfate salt
CAS:Fórmula:C23H45N5O14·H2SO4Forma y color:White to off-white powderPeso molecular:713.71Paromomycin sulfate
CAS:Producto controladoFórmula:C23H45N5O14·H2O4SForma y color:NeatPeso molecular:713.71Paromomycin sulfate, Antibiotic for Culture Media Use Only
CAS:Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (â€10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.Fórmula:C23H47N5O18SPureza:Min. 95.0 Area-%Peso molecular:713.71 g/molRef: 3D-Q-201537
1kgA consultar100gA consultar250gA consultar500gA consultar2500gA consultar-Unit-ggA consultarParomomycin Sulfate (PRM)
CAS:Fórmula:C23H45N5O14·H2SO4Forma y color:White to off-white, PowderPeso molecular:713.17Paromomycin Sulfate
CAS:Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.Fórmula:C23H47N5O18SPureza:99.73% - 99.86%Forma y color:SolidPeso molecular:713.71Paromomycin sulphate
CAS:Paromomycin sulphateFórmula:C23H45N5O14·H2SO4Pureza:Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)Forma y color: white to faint yellow powderPeso molecular:713.71g/mol
