CAS 137234-62-9: Voriconazol
Descripción:
Voriconazol es un medicamento antifúngico que se utiliza principalmente para tratar infecciones fúngicas graves, particularmente aquellas causadas por especies de Aspergillus y Candida. Pertenece a la clase de antifúngicos triazoles, que funcionan inhibiendo la enzima lanosterol 14α-demetilasa, crucial para la síntesis de ergosterol en las membranas celulares fúngicas. Voriconazol se caracteriza por su actividad de amplio espectro contra varios hongos, lo que lo hace efectivo en infecciones invasivas y no invasivas. El compuesto se administra típicamente por vía oral o intravenosa y es conocido por su buena biodisponibilidad y penetración en los tejidos. Su farmacocinética puede verse influenciada por factores como la edad, la función hepática y los medicamentos concurrentes, lo que requiere un monitoreo cuidadoso de los niveles del fármaco en algunos pacientes. Voriconazol también se asocia con efectos secundarios potenciales, incluyendo alteraciones visuales, hepatotoxicidad y reacciones cutáneas. Debido a su mecanismo de acción específico y perfil de efectos secundarios, Voriconazol a menudo se reserva para casos en los que otros tratamientos antifúngicos son ineficaces o inapropiados.
Fórmula:C16H14F3N5O
InChI:InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
Clave InChI:InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N
SMILES:[C@@]([C@@H](C)C=1C(F)=CN=CN1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3
Sinónimos:- (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
- (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
- (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
- (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
- 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
- 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
- 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,S*)]-
- Drg 0301
- G-573
- Uk 109496
- Vfend
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Voriconazole CRS
CAS:Voriconazole CRSFórmula:C16H14F3N5OForma y color:White. Powder.Peso molecular:349.3105Voriconazole
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFórmula:C16H14F3N5OForma y color:White PowderPeso molecular:349.11504Voriconazole
CAS:Fórmula:C16H14F3N5OPureza:98.0 - 102.0 %Forma y color:White to off-white crystalline powderPeso molecular:349.31Voriconazole
CAS:Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.Fórmula:C16H14F3N5OPureza:98% - 99.91%Forma y color:White To Off White Crystalline PowderPeso molecular:349.31Ref: TM-T0120
10mg35,00€25mg55,00€50mg78,00€100mg110,00€200mg158,00€500mg253,00€1mL*10mM (DMSO)40,00€Voriconazole
CAS:Fórmula:C16H14F3N5OPureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:349.32Voriconazole
CAS:Voriconazole is an antifungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. This agent also has anti-inflammatory effects and can be used to treat infections caused by Candida glabrata. Voriconazole binds to the cytoplasmic membrane, inhibiting sterol biosynthesis, which leads to cell death. It has been shown to be effective in treating infections caused by Cryptococcus neoformans and Aspergillus fumigatus and is currently being evaluated for its effectiveness against other opportunistic fungal infections such as histoplasmosis. Voriconazole is not active against bacterial or viral infections.Fórmula:C16H14F3N5OPureza:Min. 95%Forma y color:White PowderPeso molecular:349.31 g/mol4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
CAS:Fórmula:C16H14F3N5OPureza:99%Forma y color:SolidPeso molecular:349.3105Voriconazole, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C16H14F3N5OPureza:98%Forma y color:White to off-white, Crystalline powderPeso molecular:349.32(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS:Pureza:98.0%Forma y color:Solid, White to almost white powderPeso molecular:349.3169860839844Voriconazole Impurity 4
CAS:Fórmula:C16H13ClF3N5OHClForma y color:White To Off-White SolidPeso molecular:383.76 36.46
