CAS 164656-23-9: Dutasterida
Descripción:
Dutasterida es un inhibidor sintético de la 5-alfa-reductasa utilizado principalmente en el tratamiento de la hiperplasia prostática benigna (HPB) y la calvicie de patrón masculino. Funciona inhibiendo la conversión de testosterona a dihidrotestosterona (DHT), una hormona implicada en el crecimiento de la próstata y la pérdida de cabello. Dutasterida se caracteriza por su alta lipofilia, lo que le permite penetrar eficazmente en las membranas celulares. El compuesto se administra típicamente por vía oral y tiene una larga vida media, lo que contribuye a su acción sostenida en la reducción de los niveles de DHT. Se conoce por sus posibles efectos secundarios, que pueden incluir disfunción sexual, ginecomastia y cambios en los niveles de enzimas hepáticas. Además, debido a su mecanismo de acción, está contraindicado en mujeres, particularmente durante el embarazo, ya que puede afectar el desarrollo fetal. La estructura química de Dutasterida incluye un esqueleto similar a un esteroide, que es esencial para su actividad biológica. En general, Dutasterida representa un avance significativo en el manejo de condiciones relacionadas con la DHT.
Fórmula:C27H30F6N2O2
InChI:InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
Clave InChI:InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]
Sinónimos:- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (5Alpha,17Beta)-N-{2,5-Bis(Trifluoromethyl)Phenyl}-3-Oxo-4-Azaandrost-L-Ene-17-Carboxamide
- (5α,17β)-N-[(2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide
- 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
- 4-Azaandrost-1-ene-17-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-, (5α,17β)-
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Encontrado 19 productos.
Dutasteride for system suitability CRS
CAS:Dutasteride for system suitability CRSFórmula:C27H30F6N2O2Forma y color:White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.Peso molecular:528.5297Dutasteride CRS
CAS:Dutasteride CRSFórmula:C27H30F6N2O2Forma y color:White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.Peso molecular:528.5297Dutasteride
CAS:Fórmula:C27H30F6N2O2Pureza:≥ 98.0%Forma y color:White to almost white crystalline powderPeso molecular:528.53Dutasteride
CAS:Producto controladoApplications Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia. References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),Fórmula:C27H30F6N2O2Forma y color:NeatPeso molecular:528.53Dutasteride Impurity 5
CAS:Fórmula:C27H31F6NO3Forma y color:White To Off-White SolidPeso molecular:531.54Dutasteride
CAS:Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostaticFórmula:C27H30F6N2O2Pureza:99.58%Forma y color:White Crystalline SolidPeso molecular:528.53Ref: TM-T1499
5mg38,00€10mg57,00€25mg88,00€50mg105,00€100mg159,00€200mg215,00€500mg360,00€1mL*10mM (DMSO)57,00€Dutasteride
CAS:Fórmula:C27H30F6N2O2Pureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:528.54Dutasteride-13C6
CAS:Fórmula:C2113C6H30F6N2O2Forma y color:White To Off-White SolidPeso molecular:534.49Dutasteride
CAS:Adrenal cortical hormones and their derivatives nesoiFórmula:C27H30F6N2O2Forma y color:White Pale Yellow PowderPeso molecular:528.221151H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
CAS:Fórmula:C27H30F6N2O2Pureza:98%Forma y color:SolidPeso molecular:528.5297191999998Dutasteride
CAS:A dual irreversible inhibitor of 5α-reductase isoforms 5AR1 and 5AR2 with IC50 of 6 nM and 7 nM, respectively. It supresses the production of dihydrotestosterone and has been used for the treatment of benign prostatic hyperplasia, alopecia and hirsutism in women with polycystic ovary syndrome. In rodent models for Parkinson’s disease, Dutasteride reduced L-DOPA-induced dyskinesia without altering the therapeutic effect of L-DOPA.Fórmula:C27H30F6N2O2Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:528.53 g/molDutasteride - Bio-X ™
CAS:Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone. Dutasteride is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C27H30F6N2O2Pureza:(%) Min. 99%Forma y color:PowderPeso molecular:528.53 g/mol
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