CAS 16846-24-5: Josamicina
Descripción:
Josamicina es un antibiótico macrólido que se deriva principalmente de la fermentación de la bacteria Streptomyces narbonensis. Se caracteriza por su capacidad para inhibir la síntesis de proteínas bacterianas al unirse a la subunidad ribosomal 50S, impidiendo así el crecimiento de bacterias susceptibles. Josamicina exhibe un amplio espectro de actividad contra varias bacterias Gram-positivas y algunos organismos Gram-negativos, lo que lo hace efectivo en el tratamiento de infecciones del tracto respiratorio, infecciones cutáneas y ciertas enfermedades de transmisión sexual. El compuesto se administra típicamente por vía oral y es conocido por sus favorables propiedades farmacocinéticas, que incluyen una buena penetración en los tejidos y una vida media relativamente larga. Josamicina también es notable por su bajo perfil de toxicidad, lo que contribuye a su uso terapéutico. Sin embargo, al igual que otros antibióticos, puede llevar al desarrollo de resistencia a los antibióticos si se usa de manera inadecuada. Su estructura química incluye un gran anillo de lactona, que es una característica común de los antibióticos macrólidos, contribuyendo a su actividad biológica y estabilidad.
Fórmula:C42H69NO15
InChI:InChI=1/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,29+,30+,31-,34?,35?,36?,37?,38+,39+,40?,41?,42?/m1/s1
Clave InChI:InChIKey=XJSFLOJWULLJQS-NGVXBBESSA-N
SMILES:O([C@@H]1[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@@H]1CC=O)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2
Sinónimos:- (2S,3R,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
- (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
- 6-{[6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
- Antibiotic YL 704A3
- Antibiotic YL 704A<sub>3</sub>
- En 141
- Iosalide
- Jomybel
- Josacine
- Josamicina
- Josamina
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Encontrado 17 productos.
JOSAMYCIN CRS
CAS:JOSAMYCIN CRSFórmula:C42H69NO15Forma y color:White. Light Yellow. Powder., White. Light Yellow. Powder.Peso molecular:827.995Josamycin for peak identification CRS
CAS:Josamycin for peak identification CRSFórmula:C42H69NO15Peso molecular:827.995Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
CAS:Fórmula:C42H69NO15Pureza:95%Forma y color:SolidPeso molecular:827.995Josamycin 10 µg/mL in Acetonitrile
CAS:Fórmula:C42H69NO15Forma y color:Single SolutionPeso molecular:828.00JOSAMYCIN
CAS:Josamycin (EN-141) is a macrolide antibiotic exhibiting antimicrobial activity. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM.Fórmula:C42H69NO15Pureza:91.38% - 99.47%Forma y color:SolidPeso molecular:827.99Leucomycin A3
CAS:Leucomycin A3 is a macrolide antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is used for treating bacterial infections and has shown potential antiviral activity.Fórmula:C42H69NO15Pureza:Min. 95%Forma y color:White PowderPeso molecular:828 g/molJosamycin 1000 µg/mL in Acetonitrile
CAS:Producto controladoFórmula:C42H69NO15Forma y color:Single SolutionPeso molecular:828.00Josamycin, 98%
CAS:Josamycin, is used as a macrolide antibiotic effective against a variety of pathogens. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C42H69NO15Pureza:98%Forma y color:White, PowderPeso molecular:827.99(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-Hydro
CAS:(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-HydroPeso molecular:828g/molGB 31660.1-2019 Macrolide Antibiotics Mixture 167 100 µg/mL in Methanol
CAS:Producto controladoForma y color:MixtureLeucomycin A3
CAS:Applications A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. References Osono, T. et al.: J. Antibiot., 27, 366 (1974); Kuriaki, K. et al.: Jpn. J. Antibiot., 22, 232 (1969); Tan K. et al.: Zhonghua Yiyuamganranxue Zazhi, 16, 235 (2006);Fórmula:C42H69NO15Pureza:>90%Forma y color:Off-WhitePeso molecular:828.00
