CAS 169590-42-5: Celecoxib
Descripción:
Celecoxib es un fármaco antiinflamatorio no esteroideo (AINE) utilizado principalmente para el tratamiento del dolor y la inflamación asociados con condiciones como la artritis. Inhibe selectivamente la enzima ciclooxigenasa-2 (COX-2), que desempeña un papel clave en el proceso inflamatorio, reduciendo así la producción de prostaglandinas que median el dolor y la inflamación. Celecoxib se caracteriza por su fórmula química C17H14F3N3O2S y un peso molecular de aproximadamente 381.37 g/mol. Se administra típicamente por vía oral y es conocido por sus efectos secundarios gastrointestinales relativamente menores en comparación con los AINE tradicionales, ya que preserva la enzima COX-1, que está involucrada en la protección de la mucosa gástrica. Celecoxib también es reconocido por sus posibles riesgos cardiovasculares, particularmente en el uso a largo plazo, lo que requiere una cuidadosa selección y monitoreo de los pacientes. La sustancia se absorbe generalmente bien, con concentraciones plasmáticas máximas que ocurren dentro de unas pocas horas después de la administración, y se metaboliza principalmente en el hígado.
Fórmula:C17H14F3N3O2S
InChI:InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
Clave InChI:InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3
Sinónimos:- 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
- 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
- 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
- Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
- Celebra-
- Celebrex
- Celecox
- Celocoxib
- Eurocox
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Encontrado 20 productos.
Celecoxib
CAS:Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.Fórmula:C17H14F3N3O2SPureza:100% - 99.98%Forma y color:White PowderPeso molecular:381.37Celecoxib-13C6
CAS:Producto controladoFórmula:C6C11H14F3N3O2SForma y color:NeatPeso molecular:387.328Celecoxib
CAS:Producto controladoCelecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib-BioX TM also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.Fórmula:C17H14F3N3O2SPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:381.37 g/molCelecoxib
CAS:Fórmula:C17H14F3N3O2SPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:381.37Celecoxib
CAS:Producto controladoApplications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),Fórmula:C17H14F3N3O2SForma y color:NeatPeso molecular:381.37Celecoxib - Bio-X ™
CAS:Producto controladoCelecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps. Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C17H14F3N3O2SPureza:Min. 95%Forma y color:PowderPeso molecular:381.37 g/molCelecoxib
CAS:Fórmula:C17H14F3N3O2SPureza:(Titration) 98.0 - 102.0 % (dried basis)Forma y color:White or almost white powderPeso molecular:381.37Celecoxib
CAS:Sulfonamides used as drugsFórmula:C17H14F3N3O2SForma y color:PowderPeso molecular:381.07588
