CAS 207399-07-3: IR 780
Descripción:
IR 780, con el número CAS 207399-07-3, es un colorante fluorescente de infrarrojo cercano (NIR) que se utiliza principalmente en aplicaciones de imagenología biológica y terapia fototérmica. Este compuesto exhibe una fuerte absorción en la región del infrarrojo cercano, lo que permite una mayor penetración en los tejidos y reduce la fluorescencia de fondo, lo que lo hace particularmente útil en diagnósticos médicos e investigación. IR 780 se caracteriza por su alta fotostabilidad y baja toxicidad, que son esenciales para la imagenología in vivo. Además, se ha estudiado por su potencial en sistemas de entrega de medicamentos dirigidos debido a su capacidad para acumularse selectivamente en ciertos tipos de células cancerosas. Las propiedades únicas del colorante le permiten servir como una herramienta valiosa tanto en la investigación fundamental como en aplicaciones clínicas, particularmente en los campos de oncología e imagenología molecular. En general, IR 780 representa un avance significativo en el desarrollo de agentes de imagenología que pueden mejorar la visualización de procesos biológicos en tiempo real.
Fórmula:C36H44ClN2·I
InChI:InChI=1S/C36H44ClN2.HI/c1-7-24-38-30-18-11-9-16-28(30)35(3,4)32(38)22-20-26-14-13-15-27(34(26)37)21-23-33-36(5,6)29-17-10-12-19-31(29)39(33)25-8-2;/h9-12,16-23H,7-8,13-15,24-25H2,1-6H3;1H/q+1;/p-1
Clave InChI:InChIKey=IRPKBYJYVJOQHQ-UHFFFAOYSA-M
SMILES:C(CC)N1C=2C(C(C)(C)C1=CC=C3C(Cl)=C(C=CC4=[N+](CCC)C=5C(C4(C)C)=CC=CC5)CCC3)=CC=CC2.[I-]
Sinónimos:- 2-[(Z)-2-{(3E)-2-chloro-3-[(2E)-2-(3,3-dimethyl-1-propyl-1,3-dihydro-2H-indol-2-ylidene)ethylidene]cyclohex-1-en-1-yl}ethenyl]-3,3-dimethyl-1-propyl-3H-indolium iodide
- 3H-Indolium, 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide
- 3H-Indolium, 2-(2-(2-chloro-3-(2-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide (1:1)
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- Ir 780
- IR 780 iodide
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IR-780 iodide
CAS:IR-780 iodide is a water-soluble drug that has been shown to have significant cytotoxicity against prostate cancer cells. It binds to the mitochondrial membrane potential, which is involved in energy production and the regulation of the cell cycle. IR-780 iodide is taken up by tumor cells, where it inhibits adriamycin uptake and induces apoptosis. In vitro assays have shown that IR-780 iodide can be used as a diagnostic tool for detecting bladder cancer by binding to the mitochondria of cells from patients with bladder cancer. In vivo studies have been done in mice to determine the effectiveness of IR-780 iodide in treating cervical cancer. These studies showed that IR-780 iodide was not significantly effective in vivo, due to its low bioavailability and lack of specificity for cervical cancer cells. Histological analysis showed that IR-780 iodide did not inhibit tumor growth or induce apoptosis in vivo.Fórmula:C36H44ClIN2Pureza:Min. 95%Peso molecular:667.11 g/mol11-Chloro-1,1?-Di-N-Propyl-3,3,3?,3?-Tetramethyl-10,12-Trimethyleneindatricarbocyanine Iodide
CAS:11-Chloro-1,1?-Di-N-Propyl-3,3,3?,3?-Tetramethyl-10,12-Trimethyleneindatricarbocyanine IodidePureza:98%Peso molecular:667.11g/mol3H-Indolium,2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propyl-, iodide
CAS:Fórmula:C36H44ClIN2Pureza:98%Forma y color:SolidPeso molecular:667.1054IR-780 Iodide
CAS:IR-780 Iodide: a near-infrared dye for HIF-1α/glycolysis ABCB10-dependent human CSC characterization.Fórmula:C36H44ClIN2Pureza:99.98%Forma y color:SolidPeso molecular:667.1211-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide, 95%
CAS:11-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide is used as a laser and IR dye. It is also used as lithographic computer to plate laser applications. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C36H44ClIN2Pureza:95%Forma y color:Green/gold to dark green, Crystals or crystalline powderPeso molecular:667.12IR 780
CAS:Fórmula:C36H44ClIN2Pureza:>95.0%(HPLC)(qNMR)Forma y color:Yellow to Brown to Dark green powder to crystalPeso molecular:667.12
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