CAS 208255-80-5: Inhibidor de γ-secretasa IX
Descripción:
Inhibidor de γ-secretasa IX es un compuesto de molécula pequeña conocido por su papel en la inhibición del complejo γ-secretasa, que es crucial en el procesamiento de la proteína precursora de amiloide (APP) y la producción de péptidos de amiloide-beta. Esta inhibición es de particular interés en la investigación sobre la enfermedad de Alzheimer, ya que la acumulación de amiloide-beta está asociada con la neurodegeneración. El compuesto se caracteriza por su capacidad para interferir selectivamente con la actividad enzimática de la γ-secretasa, modulando así las vías de señalización involucradas en la proliferación y diferenciación celular. Su estructura química típicamente incluye grupos funcionales específicos que mejoran su afinidad de unión al sitio activo del complejo γ-secretasa. En entornos de laboratorio, Inhibidor de γ-secretasa IX se utiliza en varios ensayos para estudiar los efectos de la inhibición de la γ-secretasa en los procesos celulares y explorar estrategias terapéuticas potenciales para enfermedades neurodegenerativas. Al igual que con muchos agentes farmacológicos, la eficacia y el perfil de seguridad del compuesto son críticos para su posible aplicación en entornos clínicos.
Fórmula:C23H26F2N2O4
InChI:InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
Clave InChI:InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES:[C@@H](NC([C@@H](NC(CC1=CC(F)=CC(F)=C1)=O)C)=O)(C(OC(C)(C)C)=O)C2=CC=CC=C2
Sinónimos:- An-37124
- DAPT (enzyme inhibitor)
- Dapt
- Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
- Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
- Gsi-Ix
- Ly-374973
- N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
- N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
- N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
- tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
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Encontrado 11 productos.
DAPT
CAS:DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.Fórmula:C23H26F2N2O4Pureza:98.06% - 99.81%Forma y color:White SolidPeso molecular:432.46Ref: TM-T6202
5mg58,00€10mg88,00€25mg165,00€50mg279,00€100mg414,00€200mg517,00€500mg835,00€1mL*10mM (DMSO)59,00€(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu
CAS:(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid. It has been shown to prevent the formation of plaques in the brain and may be used to treat Alzheimer's disease. (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu has also been shown to inhibit the production of tumor necrosis factor alpha (TNFα), which is involved in inflammation and carcinogenesis. The drug has been shown to reduce myocardial infarct size by preventing cardiac cell death and reducing inflammation following a heart attack. It is also active against multiple types of cancer cells, including carcinoma cell lines and multidrug resistant cells.Fórmula:C23H26N2O4F2Pureza:Min. 95%Peso molecular:432.47 g/molDAPT
CAS:Fórmula:C23H26F2N2O4Pureza:>97.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:432.47DAPT
CAS:DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C23H26F2N2O4Forma y color:Solid, WhitePeso molecular:432.47DAPT
CAS:Fórmula:C23H26F2N2O4Pureza:(NMR) ≥ 98.0%Forma y color:White to off-white solidPeso molecular:432.50DAPT
CAS:Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2). References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)Fórmula:C23H26F2N2O4Forma y color:Off White SolidPeso molecular:432.46DAPT
CAS:Inhibitor of proteaseγâsecretase, which allows to modulate of the activity of γâsecretase substrates Notch, E-cadherin, ErbB4, and amyloid precursor protein (APP). The compound can inhibit the growth of tongue carcinoma cells by arresting cell cycle in G0-G1 phase, modulate the activity of Notch1 receptor and Caspase-3 protease and induce apoptosis. It was also demonstrated that this inhibitor reduces the levels of β-amyloid peptide in the brain of mice model for Alzheimer’s disease. This compound also enhances the neuronal differentiation embryonic cells.Fórmula:C23H26O4N2F2Pureza:Min. 95%Forma y color:White PowderPeso molecular:432.46 g/mol(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu
CAS:(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.Fórmula:C23H26N2O4F2Pureza:Min. 95%Peso molecular:432.46 g/molGlycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
CAS:Fórmula:C23H26F2N2O4Pureza:98%Forma y color:SolidPeso molecular:432.4603
![Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA002JLH.jpg&w=3840&q=75)
