CAS 20830-75-5: Digoxina
Descripción:
Digoxina es un glucósido cardíaco derivado de las hojas de la planta de digital (Digitalis purpurea) y se utiliza principalmente en el tratamiento de diversas afecciones cardíacas, particularmente la fibrilación auricular y la insuficiencia cardíaca. Funciona inhibiendo la bomba de ATPasa sodio-potasio, lo que lleva a un aumento en las concentraciones de calcio intracelular, lo que mejora la contractilidad cardíaca. Digoxina se caracteriza por su ventana terapéutica relativamente estrecha, lo que significa que la diferencia entre una dosis efectiva y una dosis tóxica es pequeña, lo que requiere un monitoreo cuidadoso de los niveles séricos en los pacientes. Se administra típicamente por vía oral o intravenosa y es conocido por sus posibles efectos secundarios, que pueden incluir trastornos gastrointestinales, cambios visuales y arritmias. La sustancia tiene una fórmula molecular de C41H64O14 y un peso molecular de aproximadamente 780.94 g/mol. La farmacocinética de Digoxina se ve influenciada por factores como la función renal y las interacciones con otros medicamentos, lo que hace que la dosificación individualizada sea esencial para un uso seguro y efectivo.
Fórmula:C41H64O14
InChI:InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
Clave InChI:InChIKey=LTMHDMANZUZIPE-PUGKRICDSA-N
SMILES:O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]
Sinónimos:- (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
- (3beta,5beta,8xi,9xi,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
- (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
- 12β-Hydroxydigitoxin
- Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
- Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
- Cardigox
- Cardiogoxin
- Cardioxin
- Cardixin
- Cardoxin
- Ver más sinónimos
Ordenar por
DIGOXIN CRS
CAS:DIGOXIN CRSFórmula:C41H64O14Forma y color:White. Whitish. Powder.Peso molecular:780.9385Digoxin for peak identification CRS
CAS:Digoxin for peak identification CRSFórmula:C41H64O14Peso molecular:780.9385Digoxin
CAS:Producto controladoApplications Cardiotonic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Aronson, J.K., et al.: Clin. Pharmacokinet, 5,137 (1980), Foss, P.R.B., Anal. Profiles Drug Subs., 9, 207 (1980),Fórmula:C41H64O14Forma y color:WhitePeso molecular:780.94Digoxin extrapure, 95%
CAS:Fórmula:C41H64O14Pureza:min. 95%Forma y color:White to off white, Crystalline powder, ClearPeso molecular:780.94Ref: SR-48712
Producto descatalogado12β-Hydroxydigitoxin
CAS:Please enquire for more information about 12beta-Hydroxydigitoxin including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C41H64O14Peso molecular:780.95 g/molDigoxin
CAS:Digoxin and its derivatives are the most widely used as cardiac glycosides. Digoxin is isolated from the foxglove plant, Digitalis lanata, and has pharmacokinetic properties that are intermediate between digitoxin and the short acting strophanthus glycosides. Digoxin is regarded as the drug of choice for the treatment of congestive heart failure as its main assets are the rapid onset of action, good absorption ratio and the medium half-life which makes toxic reactions easier to manage (Albrecht, 1999).Fórmula:C41H64O14Pureza:Min. 95%Forma y color:PowderPeso molecular:780.94 g/molDigoxin, 96%
CAS:Digoxin is used in several cardiac pathologies such as atrial fibrillation and heart failure. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C41H64O14Pureza:96%Forma y color:Powder, WhitePeso molecular:780.95Digoxin
CAS:Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. Digoxin and other cardiac glycosides can inhibit hypoxia-inducible factor 1 (HIF-1)α synthesis and block tumor growth.Fórmula:C41H64O14Pureza:95%~99%Peso molecular:780.949Digoxin
CAS:Digoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Fórmula:C41H64O14Pureza:(HPLC) ≥95%Forma y color:PowderPeso molecular:780.95Digoxin, 95%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C41H64O14Pureza:95%Forma y color:Crystalline powder or crystals, White to off-whitePeso molecular:780.95
