CAS 2353-33-5: 5-Aza-2'-desoxicitidina
Descripción:
5-Aza-2'-desoxicitidina, también conocido como decitabina, es un análogo de nucleósido de la citidina que se utiliza principalmente en el tratamiento de ciertos tipos de cáncer, particularmente síndromes mielodisplásicos y leucemia mieloide aguda. Su estructura química presenta una base pirimidínica, específicamente una citosina modificada, donde el átomo de nitrógeno en la posición 5 es reemplazado por un átomo de carbono, lo que resulta en la incorporación de un grupo metilo. Esta modificación inhibe las metiltransferasas de ADN, lo que lleva a la hipometilación del ADN y la reactivación de genes silenciados, lo que puede inducir diferenciación y apoptosis en células cancerosas. 5-Aza-2'-desoxicitidina se administra típicamente por vía intravenosa y tiene una vida media relativamente corta, lo que requiere protocolos de dosificación y administración cuidadosos. Sus efectos terapéuticos están acompañados de posibles efectos secundarios, incluyendo mielosupresión y trastornos gastrointestinales. Como herramienta de investigación, también se utiliza en estudios epigenéticos para investigar el papel de la metilación del ADN en la expresión génica y la función celular.
Fórmula:C8H12N4O4
InChI:InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
Clave InChI:InChIKey=XAUDJQYHKZQPEU-KVQBGUIXSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=NC(N)=N1
Sinónimos:- 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-
- 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-
- 2'-Deoxy-5-azacytidine
- 2'-Desoxy-5-Azacytidine
- 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin
- 4-Amino-1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
- 4-Amino-1-(2-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-1,3,5-triazin-2(1H)-one
- 4-Amino-1-(2-desoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-on
- 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
- 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
- 4-amino-1-(2-deoxypentofuranosyl)-1,3,5-triazin-2(1H)-one
- Ver más sinónimos
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Encontrado 18 productos.
5-Aza-2''-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:≥ 97.5% (dried basis)Forma y color:White crystalline powderPeso molecular:228.215-Aza-2'-deoxycytidine, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C9H13N3O4Pureza:98%Forma y color:Powder, White to off-whitePeso molecular:227.225-Aza-2’-deoxy Cytidine-15N4
CAS:Producto controladoApplications Labelled 5-Aza-2’-deoxy Cytidine (A796950). Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),Fórmula:C8H1215N4O4Forma y color:NeatPeso molecular:232.185-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:228.21Decitabine-15N4 (5-Aza-2'-Deoxy Cytidine-15N4)
CAS:Fórmula:C8H1215N4O4Forma y color:White To Off-White SolidPeso molecular:232.181,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-
CAS:Fórmula:C8H12N4O4Pureza:98%Forma y color:SolidPeso molecular:228.2053Decitabine (5-Aza-2'-Deoxy Cytidine)
CAS:Fórmula:C8H12N4O4Forma y color:White To Off-White SolidPeso molecular:228.21Decitabine, Free Base
CAS:Decitabine, Free BaseFórmula:C8H12N4O4Pureza:By hplc: 98.3% by area (Typical Value in Batch COA)Forma y color: white powderPeso molecular:228.21g/molDecitabine
CAS:A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.Fórmula:C8H12N4O4Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:228.21 g/molDecitabine - Bio-X ™
CAS:Decitabine is a synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. It has demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Also, it has anti-growth effects on solid tumor cell lines. Decitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C8H12N4O4Pureza:Min. 95%Forma y color:PowderPeso molecular:228.21 g/mol5-Aza-2’-deoxy Cytidine
CAS:Producto controladoApplications 5-Aza-2’-deoxy Cytidine is used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),Fórmula:C8H12N4O4Forma y color:NeatPeso molecular:228.21Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Forma y color:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21Decitabine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C8H12N4O4Forma y color:White Off-White PowderPeso molecular:228.085855-Aza-2'-deoxycytidine, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C9H13N3O4Pureza:98%Forma y color:White to off-white to pale yellow, PowderPeso molecular:227.22
