CAS 25316-40-9: Clorhidrato de doxorrubicina
Descripción:
Clorhidrato de doxorrubicina es un antibiótico antraciclínico comúnmente utilizado en la quimioterapia del cáncer. Se caracteriza por su color rojo brillante y es conocido por su potente actividad antitumoral. El compuesto actúa intercalando el ADN, inhibiendo así la síntesis de ácidos nucleicos y perturbando la replicación de las células cancerosas. La doxorubicina es soluble en agua y presenta un perfil de solubilidad dependiente del pH, lo cual es importante para su formulación y administración. Su mecanismo de acción también implica la generación de radicales libres, contribuyendo a sus efectos citotóxicos. Sin embargo, el uso de doxorubicina está asociado con varios efectos secundarios, incluida la cardiotoxicidad, que limita su dosis acumulativa. Se administra típicamente por vía intravenosa y a menudo se utiliza en combinación con otros agentes quimioterapéuticos para mejorar la eficacia contra diversas malignidades, incluyendo el cáncer de mama, leucemia y linfomas. Debido a sus significativos beneficios terapéuticos y riesgos potenciales, el monitoreo y manejo cuidadosos son esenciales durante el tratamiento.
Fórmula:C27H29NO11·ClH
InChI:InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Clave InChI:InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Sinónimos:- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
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DOXORUBICIN HYDROCHLORIDE RS
CAS:DOXORUBICIN HYDROCHLORIDE RSFórmula:C27H29NO11Peso molecular:543.5193DOXORUBICIN HYDROCHLORIDE CRS
CAS:DOXORUBICIN HYDROCHLORIDE CRSFórmula:C27H29NO11Forma y color:Crystalline Powder. Orange. Red. Powder.Peso molecular:543.5193Doxorubicin hydrochloride, 10 mg/ml aqueous solution
CAS:Doxorubicin hydrochloride, 10 mg/ml aqueous solution, is a chemotherapeutic agent, which is an anthracycline antibiotic derived from the bacterium *Streptomyces peucetius var. caesius*. Its mode of action involves the intercalation into DNA, disrupting the replication and transcription processes crucial for cancer cell proliferation. Additionally, it generates free radicals that cause further damage to cellular structures and inhibit topoisomerase II, thereby preventing the unwinding of DNA necessary for replication. This compound is primarily used in the treatment of a wide range of cancers, including leukemia, lymphomas, breast cancer, and various solid tumors. Due to its efficacy in halting the growth of rapidly dividing cells, doxorubicin is a cornerstone in many chemotherapy regimens. However, its use is carefully monitored due to dose-dependent cardiotoxicity, necessitating patient-specific therapeutic approaches and regular cardiac evaluations. As a critical component in cancer therapeutics, doxorubicin hydrochloride continues to be the subject of extensive research, seeking to maximize efficacy while minimizing adverse effects.Fórmula:C27H29NO11•HClPureza:Min. 95%Forma y color:PowderPeso molecular:579.98 g/molDoxorubicin Hydrochloride
CAS:Producto controladoFórmula:C27H29NO11·ClHForma y color:NeatPeso molecular:579.98Doxorubicin hydrochloride
CAS:Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C27H30ClNO11Forma y color:Crystalline powder or granular, Red to orangePeso molecular:579.98Doxorubicin hydrochloride - Bio-X ™
CAS:Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Doxorubicin hydrochloride is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C27H29NO11•HClPureza:Min. 95%Forma y color:PowderPeso molecular:579.98 g/molDoxorubicin hydrochloride, USP grade
CAS:Fórmula:C27H29NO11·HClPureza:≥ 98.0% (anhydrous, solvent-free)Forma y color:Orange-red to red crystalline powderPeso molecular:579.99(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS:Fórmula:C27H30ClNO11Pureza:%Forma y color:SolidPeso molecular:579.9802Doxorubicin hydrochloride
CAS:Pureza:95.0%Forma y color:Solid, Crystalline Powder or Granules or PowderPeso molecular:579.15073846Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Fórmula:C13C22H26D3NO11·HClPeso molecular:547.56 36.45Doxorubicin Hydrochloride
CAS:Fórmula:C27H29NO11·HClPureza:>95.0%(HPLC)Forma y color:Light yellow to Brown powder to crystalPeso molecular:579.98Doxorubicin hydrochloride, 98%
CAS:Fórmula:C27H29NO11·HClPureza:(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Forma y color:Orange-red to red crystalline powderPeso molecular:579.99Doxorubicin-HCl
CAS:Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.Fórmula:C27H29NO11•HClPureza:Min. 95%Peso molecular:616.44 g/molDes-[(4-Amino-2,3,6-trideoxy-hexapyranosyl)oxy)-1-methyl] 2-Carboxylate Doxorubicin
CAS:Producto controladoFórmula:C20H12O7Forma y color:NeatPeso molecular:364.305Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11·ClHPureza:99%Forma y color: orange red crystalline powderPeso molecular:579.98g/molDoxorubicin hydrochloride
CAS:Producto controladoFórmula:C27H29NO11·ClHForma y color:NeatPeso molecular:579.98
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