CAS 287714-41-4: Rosuvastatina
Descripción:
Rosuvastatina es un agente sintético reductor de lípidos que pertenece a la clase de las estatinas, utilizado principalmente para manejar la hiperlipidemia y reducir el riesgo de enfermedades cardiovasculares. Su fórmula química es C22H28FN3O6S, y presenta una estructura distintiva que incluye un grupo fluorofenilo y un moiety de sulfonamida, lo que contribuye a su potencia. Rosuvastatina actúa inhibiendo la HMG-CoA reductasa, una enzima crucial para la biosíntesis de colesterol en el hígado, reduciendo así los niveles de colesterol de lipoproteínas de baja densidad (LDL) y triglicéridos, mientras aumenta el colesterol de lipoproteínas de alta densidad (HDL). El fármaco se caracteriza por su alta biodisponibilidad y larga vida media, lo que permite una dosificación una vez al día. Generalmente es bien tolerado, aunque los efectos secundarios potenciales pueden incluir dolor muscular, elevaciones de enzimas hepáticas y trastornos gastrointestinales. Rosuvastatina a menudo se prescribe junto con modificaciones en el estilo de vida, como dieta y ejercicio, para mejorar sus efectos reductores de colesterol. Su perfil de eficacia y seguridad lo convierte en un medicamento ampliamente utilizado en el manejo de la dislipidemia.
Fórmula:C22H28FN3O6S
InChI:InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1
Clave InChI:InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N
SMILES:C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2
Sinónimos:- (3R,5R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
- (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid
- (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid
- (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
- 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
- 7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methyl-Methylsulfonyl-Amino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-Hept-6-Enoic Acid
- Azd 4522
- Azd4522
- Rosuvastatin Acid
- Rosuvastatin intermediates
- X-Plended
- Ver más sinónimos
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Encontrado 14 productos.
Rosuvastatin
CAS:Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis. Its primary use is in the management of hypercholesterolemia and related conditions, aimed at reducing cardiovascular morbidity and mortality. Clinical studies have demonstrated its efficacy in not only lowering LDL cholesterol but also in raising high-density lipoprotein (HDL) cholesterol and reducing triglycerides. Furthermore, Rosuvastatin has applications in primary prevention among patients at risk for coronary artery disease, as well as in secondary prevention in those with established cardiovascular disease. Its pharmacokinetic properties, including a long half-life and minimal drug-drug interaction, make it a well-tolerated choice among statins. Continued research is expanding its clinical applications, examining benefits beyond lipid modulation.Fórmula:C22H28FN3O6SPureza:Min. 95%Peso molecular:481.54 g/molN-Desmethyl N-ethyl Rosuvastatin Sodium Salt
CAS:Producto controladoFórmula:C23H29FN3NaO6SForma y color:NeatPeso molecular:517.5467,8-Dihydro-rosuvastatin Diisopropylammonium Salt
CAS:Producto controladoFórmula:C28H45FN4O6SForma y color:NeatPeso molecular:584.74Rosuvastatin-d3 sodium salt
CAS:Fórmula:C22H24D3FN3O6S·NaForma y color:Yellow SolidPeso molecular:483.56 22.99(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
CAS:Producto controladoApplications (3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic. References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)Fórmula:C22H27FN3NaO6SForma y color:NeatPeso molecular:503.519Rosuvastatin
CAS:Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.Fórmula:C22H28FN3O6SPureza:95.24% - 99.8%Forma y color:SolidPeso molecular:481.546-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
CAS:Fórmula:C22H28FN3O6SPureza:98%Forma y color:SolidPeso molecular:481.5376Rosuvastatin Calcium
CAS:Fórmula:C44H54CaF2N6O12S2Pureza:>95.0%(HPLC)(N)Forma y color:White to Almost white powder to crystalPeso molecular:1,001.14(3S,5R)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
CAS:Producto controladoFórmula:C22H27FN3NaO6SForma y color:NeatPeso molecular:503.519rac-Rosuvastatin Sodium Salt (Mixture: R700515 and Sodium Salt of R700500)
CAS:Producto controladoFórmula:C22H27FN3NaO6SForma y color:NeatPeso molecular:503.519rac-Rosuvastatin Sodium Salt (E/Z Mixture)
CAS:Producto controladoFórmula:C22H27FN3NaO6SForma y color:NeatPeso molecular:503.52
![(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb%2FF592055.jpg&w=3840&q=75)
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