CAS 29767-20-2: Teniposido
Descripción:
Teniposido, con el número CAS 29767-20-2, es un derivado semisintético de la podofilotoxina, utilizado principalmente como agente antineoplásico en la terapia del cáncer. Funciona inhibiendo la topoisomerasa II, una enzima crucial para la replicación y reparación del ADN, induciendo así daño en el ADN y apoptosis en células cancerosas de rápida división. Teniposido se administra típicamente por vía intravenosa y está indicado para el tratamiento de diversas malignidades, incluyendo ciertos tipos de leucemia y tumores sólidos. El compuesto se caracteriza por su compleja estructura química, que incluye un grupo fenólico y un enlace éter, contribuyendo a su actividad biológica. Generalmente es soluble en disolventes orgánicos, pero tiene una solubilidad limitada en agua. Los efectos secundarios pueden incluir mielosupresión, trastornos gastrointestinales y reacciones de hipersensibilidad. Debido a sus potentes efectos y potencial toxicidad, Teniposido generalmente se prescribe bajo estricta supervisión médica, con un cuidadoso monitoreo de la respuesta del paciente y los efectos secundarios durante el tratamiento.
Fórmula:C32H32O13S
InChI:InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
Clave InChI:InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]
Sinónimos:- (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- EPT
- Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
- Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
- Nsc 122819
- Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
- S 122819
- Teniposid
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Encontrado 11 productos.
Teniposide
CAS:Type II topoisomerase inhibitorFórmula:C32H32O13SPureza:Min. 95%Forma y color:PowderPeso molecular:656.65 g/molTeniposide
CAS:Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFórmula:C32H32O13SPureza:97.70% - 99.45%Forma y color:White Or Off-White Crystalline PowderPeso molecular:656.65Teniposide - Bio-X ™
CAS:Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute lymphoblastic leukemia. It has antitumour activity. It is a type II topoisomerase inhibitor. This drug inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. Teniposide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C32H32O13SPureza:Min. 95%Forma y color:PowderPeso molecular:656.65 g/molTeniposide
CAS:Fórmula:C32H32O13SPureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalinePeso molecular:656.66Teniposide
CAS:Fórmula:C32H32O13SPureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:656.65Teniposide
CAS:Producto controladoStability Hygroscopic Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic. References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),Fórmula:C32H32O13SForma y color:NeatPeso molecular:656.655-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS:Fórmula:C32H32O13SPureza:98%Forma y color:SolidPeso molecular:656.6537(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1
CAS:(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1Pureza:98%Peso molecular:656.65g/molTeniposide (PLANNED TO BE DISCONTINUED)
CAS:Other glycosides, natural or reproduced by synthesis, aFórmula:C32H32O13SForma y color:PowderPeso molecular:656.15636
![5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00I5IB.jpg&w=3840&q=75)
![(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1026151.jpg&w=3840&q=75)
