CAS 32986-56-4: Tobramicina
Descripción:
Tobramicina es un antibiótico aminoglucósido que se utiliza principalmente para tratar infecciones causadas por bacterias Gram-negativas, particularmente Pseudomonas aeruginosa. Es efectivo contra una variedad de infecciones bacterianas, especialmente en pacientes con fibrosis quística o aquellos con sistemas inmunológicos comprometidos. La sustancia se caracteriza por su capacidad para inhibir la síntesis de proteínas bacterianas al unirse a la subunidad ribosómica 30S, lo que lleva a una lectura incorrecta del ARNm y, en última instancia, a la muerte celular. Tobramicina se administra típicamente por inhalación, inyección o aplicación tópica, dependiendo de la ubicación y gravedad de la infección. Se conoce por su toxicidad relativamente baja en comparación con otros aminoglucósidos, aunque aún puede causar nefrotoxicidad y ototoxicidad, lo que requiere un monitoreo cuidadoso de la función renal y la audición durante el tratamiento. La estructura química de Tobramicina incluye múltiples grupos hidroxilo y amino, lo que contribuye a su solubilidad y actividad biológica. Al igual que con todos los antibióticos, la aparición de resistencia es una preocupación, lo que hace que el uso apropiado y la adherencia a los regímenes prescritos sean esenciales para mantener su eficacia.
Fórmula:C18H37N5O9
InChI:InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
Clave InChI:InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N
SMILES:O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
Sinónimos:- (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
- 3'-Deoxykanamycin B
- 4-Amino-2-[4,6-Diamino-3-[[2-Amino-5-(Aminomethyl)-4-Hydroxy-Cyclohexyl]Methyl]-2-Hydroxy-Cyclohexoxy]-6-(Hydroxymethyl)Tetrahydropyran-3,5-Diol
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-
- D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino- 2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
- Deoxykanamycin B
- Nebramycin 6
- Nebramycin VI
- Nebramycin factor 6
- Nf 6
- Nsc 180514
- Ver más sinónimos
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Tobramycin for identification CRS
CAS:Tobramycin for identification CRSFórmula:C18H37N5O9Forma y color:White. Powder.Peso molecular:467.5145SECOND INTERNATIONAL STANDARD FOR TOBRAMYCIN
CAS:SECOND INTERNATIONAL STANDARD FOR TOBRAMYCINFórmula:C18H37N5O9Peso molecular:467.5145Tobramycin (TBM)
CAS:Fórmula:C18H37N5O9Pureza:min. 900 µg/mgForma y color:White, PowderPeso molecular:467.5Tobramycin - high purity
CAS:Inhibitor of protein synthesis; aminoglycosideFórmula:C18H37N5O9Pureza:Min. 900 Ug/MgForma y color:PowderPeso molecular:467.51 g/molTobramycin, EP grade
CAS:Fórmula:C18H37N5O9Pureza:≤ 0.5%Forma y color:White to off-white powderPeso molecular:467.5Tobramycin, 97%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H37N5O9Pureza:97%Forma y color:White to light yellow, PowderPeso molecular:467.52Tobramycin
CAS:Aminoglycoside antibioticsFórmula:C18H37N5O9Forma y color:White Off-White PowderPeso molecular:467.25913Tobramycin, Antibiotic for Culture Media Use Only
CAS:Producto controladoTobramycin is used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.Fórmula:C18H37N5O9Pureza:Min. 97 Area-%Peso molecular:467.51 g/molRef: 3D-Q-201837
10gA consultar25gA consultar50gA consultar100gA consultar250gA consultar-Unit-ggA consultarTobramycin
CAS:TobramycinFórmula:C18H37N5O9Pureza:>97% by area (tlc) (Typical Value in Batch COA)Forma y color: white powderPeso molecular:467.51g/molTobramycin Sulphate Salt
CAS:Fórmula:C18H37N5O9•x(H2O4S)Forma y color:NeatPeso molecular:467.51+x(98.08)Ref: IN-DA00I6BT
1g26,00€5g69,00€10g105,00€15g123,00€25g176,00€50g240,00€75g354,00€100g601,00€100mg30,00€200mg30,00€Tobramycin
CAS:Fórmula:C18H37N5O9Pureza:>94.0%(T)Forma y color:White to Orange to Green powder to crystalPeso molecular:467.52Tobramycin Deuterated
CAS:Producto controladoStability Hygroscopic Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9. References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),Fórmula:C18H37N5O9forundeuteratedForma y color:Dark YellowPeso molecular:467.51Tobramycin
CAS:Tobramycin used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.Fórmula:C18H37N5O9Pureza:Min. 97 Area-%Forma y color:White PowderPeso molecular:467.51 g/molTobramycin
CAS:Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.Fórmula:C18H37N5O9Pureza:99.21% - 99.87%Forma y color:White SolidPeso molecular:467.51Tobramycin, 900μg/mg
CAS:Primarily targets Gram-negative bacteria This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H37N5O9Forma y color:White to pale cream, PowderPeso molecular:467.52
