CAS 33069-62-4: Paclitaxel
Descripción:
Paclitaxel, con el número CAS 33069-62-4, es un producto natural complejo y un agente quimioterapéutico utilizado principalmente en el tratamiento de varios tipos de cáncer, incluyendo cáncer de ovario, de mama y de pulmón. Se deriva de la corteza del tejo del Pacífico (Taxus brevifolia) y se clasifica como un taxano. Paclitaxel funciona estabilizando los microtúbulos y previniendo su despolimerización, lo que interrumpe el proceso normal de división celular, llevando finalmente a la apoptosis en las células cancerosas. El compuesto se caracteriza por su estructura única, que incluye un sistema de anillo de taxano y varios grupos funcionales que contribuyen a su actividad biológica. Paclitaxel se administra típicamente por vía intravenosa y tiene una solubilidad relativamente baja en agua, a menudo requiriendo formulación con solventes como Cremophor EL para uso clínico. Sus efectos secundarios pueden incluir neutropenia, reacciones de hipersensibilidad y neuropatía periférica. Debido a su eficacia y mecanismo de acción, Paclitaxel sigue siendo una piedra angular en las terapias oncológicas, aunque su uso a menudo va acompañado de un monitoreo cuidadoso y atención de apoyo.
Fórmula:C47H51NO14
InChI:InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
Clave InChI:InChIKey=RCINICONZNJXQF-MZXODVADSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]
Sinónimos:- 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
- Abi 007
- Abraxane
- Anzatax
- Apealea
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- Bms 181339-01
- Capxol
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Paclitaxel CRS
CAS:Paclitaxel CRSFórmula:C47H51NO14Forma y color:Crystalline Powder. White. Powder.Peso molecular:853.9061Paclitaxel semi-synthetic for system suitability CRS
CAS:Paclitaxel semi-synthetic for system suitability CRSPaclitaxel natural for peak identification CRS
CAS:Paclitaxel natural for peak identification CRSFórmula:C47H51NO14Peso molecular:853.9061Paclitaxel semi-synthetic for peak identification CRS
CAS:Paclitaxel semi-synthetic for peak identification CRSFórmula:C47H51NO14Peso molecular:853.9061Paclitaxel-13C6
CAS:Producto controladoApplications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),Fórmula:C4113C6H51NO14Forma y color:NeatPeso molecular:859.86Paclitaxel
CAS:Fórmula:C47H51NO14Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:853.927,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
CAS:Fórmula:C47H51NO14Forma y color:SolidPeso molecular:853.9061Paclitaxel (Docetaxel EP Impurity F)
CAS:Fórmula:C47H51NO14Forma y color:White To Off-White SolidPeso molecular:853.92Paclitaxel
CAS:Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.Fórmula:C47H51NO14Pureza:Min. 95%Forma y color:White Clear LiquidPeso molecular:853.91 g/molPaclitaxel, 99+%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C47H51NO14Pureza:99+%Forma y color:White, PowderPeso molecular:853.92Paclitaxel
CAS:Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats.Fórmula:C47H51NO14Pureza:95%~99%Peso molecular:853.918Taxol
CAS:Oxygen-heterocyclic compoundFórmula:C47H51NO14Pureza:≥ 95.0 % (HPLC)Forma y color:PowderPeso molecular:853.92Paclitaxel, 99.5+%
CAS:Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C47H51NO14Pureza:99.5+%Forma y color:White to cream, Crystalline powder or granularPeso molecular:853.92Paclitaxel (Taxol, PCXL), 99%
CAS:Fórmula:C47H51NO14Pureza:min. 99%Forma y color:White, PowderPeso molecular:853.91Paclitaxel
CAS:Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.Fórmula:C47H51NO14Pureza:Min. 96.0 Area-%Peso molecular:853.91 g/molPaclitaxel
CAS:Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),Fórmula:C47H51NO14Forma y color:Off-WhitePeso molecular:853.91
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