CAS 3922-90-5: Oleandomicina

Descripción:

Oleandomicina es un antibiótico macrólido que está estructuralmente relacionado con la eritromicina. Se produce mediante la fermentación de ciertas cepas de Streptomyces, específicamente Streptomyces antibioticus. Oleandomicina exhibe actividad antibacteriana principalmente contra bacterias Gram-positivas y algunos organismos Gram-negativos, lo que lo hace efectivo en el tratamiento de diversas infecciones bacterianas. El compuesto funciona inhibiendo la síntesis de proteínas bacterianas, uniéndose a la subunidad ribosomal 50S, lo que impide la elongación de la cadena polipeptídica durante la traducción. Oleandomicina se administra típicamente por vía oral y es conocido por su toxicidad relativamente baja. Sin embargo, puede causar efectos secundarios como trastornos gastrointestinales y reacciones alérgicas en algunas personas. Su uso ha disminuido con la llegada de antibióticos más nuevos, pero sigue siendo de interés en ciertos escenarios clínicos. La estructura química de Oleandomicina incluye un gran anillo de lactona, que es característico de los antibióticos macrólidos, contribuyendo a su mecanismo de acción y propiedades farmacológicas.

Fórmula:C₃₅H₆₁NO₁₂

InChI:InChI=1S/C35H61NO12/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34/h16-31,34,37-39H,12-15H2,1-11H3/t16-,17+,18-,19+,20+,21+,22+,23-,24-,25-,26-,27-,28-,29+,30-,31-,34-,35+/m0/s1

Clave InChI:InChIKey=RZPAKFUAFGMUPI-QESOVKLGSA-N

SMILES:O=C1[C@]2(CO2)C[C@H](C)[C@H](O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@H]1C

Sinónimos:

1,9-Dioxaspiro[2.13]hexadecane, oleandomycin deriv.
1,9-Dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, [3R-(3R*,5R*,6S*,7R*,8R*,11R*,12S*,13R*,14S*,15S*)]-
1,9-Dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, [3R-(3R*,5R*,6S*,7R*,8R*,11R*,12S*,13R*,14S*,15S*)]-
Amimycin
Antibiotic PA 105
Landomycin
Nonanoic acid, 8-(3,5-dihydroxy-2,4-dimethylhexanoyl)-5-(4-dimethylaminotetrahydro-3-hydroxy-6-methylpyran-2-yloxy)-8,9-epoxy-2,4,6-trimethyl-3-(tetrahydro-5-hydroxy-4-methoxy-6-methylpyran-2-yloxy)-, μ-lactone
Oleandomicina
Oleandomycin A
Oleandomycine
Pa 105
Pa 775
Romicil
[3R-(3R*,5R*,6S*,7R*,8R*,11R*,12S*,13R*,14S*,15S*)]-12-[(2,6-Dideoxy-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-1,9-dioxaspiro[2.13]hexadecane-4,10-dione
[3R-(3R*,5R*,6S*,7R*,8R*,11R*,12S*,13R*,14S*,15S*)]-12-[(2,6-Dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1,9-dioxaspiro[2.13]hexadecane-4,10-dione
(3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-12-[(2,6-dideoxy-3-O-methylhexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadec-14-yl 3,4,6-trideoxy-3-(dimethylamino)hexopyranoside
Oleandomycin
12-((2,6-Didesoxy-3-O-methyl-alpha-K-arabino-hexopyranosyl)oxy)-8-hydroxy-5,7,8,11,13,15-hexamethyl-14-((3,4,6-tridesoxy-3-dimethylamino-beta-D-xylo-hexopyranosyl)oxy)-1,9-dioxaspiro(2.13)hexadecan-4,10-dion
Oleandomycinum [INN-Latin]
(3R,5R,6S,7R,8R,11S,12S,13R,14S,15S)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside
AI3-50163
HSDB 7442
(3R,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside
Oleandomycin (chloroform solvate)
Oleandomycine [INN-French]
(3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside phosphate (salt)
(3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside
Oleandomycine [French]
UNII-P8ZQ646136
Oleandomicina [INN-Spanish]
Matromycin
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Encontrado 8 productos.

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oleandomycin
CAS:
- 3922-90-5
Fórmula:C₃₅H₆₁NO₁₂
Pureza:99.0%
Forma y color:Solid
Peso molecular:687.8583
Ref: IN-DA00CJ6G
5mg
625,00€
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10mg
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Oleandomycin
CAS:
- 3922-90-5
Oleandomycin is a macrolide antibiotic, which is derived from the bacterium *Streptomyces antibioticus*. This antibiotic functions by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. The interruption of this essential process ultimately leads to the cessation of bacterial growth and replication. Oleandomycin is primarily utilized in the treatment of infections caused by Gram-positive bacteria and some Gram-negative bacteria. Its efficacy is notable in respiratory tract infections, skin infections, and in certain cases, it is used as an alternative for patients allergic to penicillin. While it offers significant therapeutic benefits, careful consideration must be given to its application, as resistance can develop due to bacterial adaptation. In a research context, Oleandomycin serves as a useful tool in studies exploring bacterial protein synthesis and resistance mechanisms.
Fórmula:C₃₅H₆₁NO₁₂
Pureza:Min. 95%
Forma y color:White Powder
Peso molecular:687.86 g/mol
Ref: 3D-AO16827
50mg
2.200,00€
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100mg
3.299,00€
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250mg
5.499,00€
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Oleandomycin
CAS:
- 3922-90-5
Peso molecular:687.867980957031
Ref: 10-F951503
5mg
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Oleandomycin 1000 µg/mL in Acetonitrile
CAS:
- 3922-90-5
Fórmula:C₃₅H₆₁NO₁₂
Ref: TR-DRE-A15725990AL-1000
1ml
785,00€
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Oleandomycin
CAS:
- 3922-90-5
Fórmula:C₃₅H₆₁NO₁₂
Pureza:≥ 95.0%
Forma y color:White powder
Peso molecular:687.90
Ref: 7W-GA0872
ne
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Oleandomycin
CAS:
- 3922-90-5
Fórmula:C₃₅H₆₁NO₁₂
Peso molecular:687.87
Ref: 4Z-O-101001
5mg
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10mg
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25mg
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50mg
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100mg
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Oleandomycin 1000 µg/mL in Acetonitrile
Producto controladoPor favor, tenga en cuenta que se trata de un producto controlado en algunos países y debe tratarse de acuerdo con la normativa pertinente. Tenga en cuenta que esto puede conllevar gastos y documentación adicionales.
CAS:
- 3922-90-5
Fórmula:C₃₅H₆₁NO₁₂
Forma y color:Single Solution
Peso molecular:687.86
Ref: 04-A15725990AL-1000
1ml
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Oleandomycin
CAS:
- 3922-90-5
Oleandomycin, a macrolide antibiotic structurally similar to Erythromycin, exhibits antimicrobial activity.
Fórmula:C₃₅H₆₁NO₁₂
Pureza:98%
Forma y color:White Amorphous Powder Solid
Peso molecular:687.86
Ref: TM-T16382
50mg
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