CAS 486-35-1: Dafnetina
Descripción:
Dafnetina, con el número CAS 486-35-1, es un derivado de cumarina que se encuentra de forma natural, extraído principalmente de la corteza del género Daphne, en particular de Daphne mezereum. Se caracteriza por su apariencia cristalina blanca y tiene una fórmula molecular de C10H8O4. Dafnetina exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, antioxidantes y antimicrobianas, lo que lo hace de interés en la investigación farmacológica. El compuesto es soluble en disolventes orgánicos como el etanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. La estructura de Dafnetina presenta un grupo hidroxilo y un grupo metoxi, lo que contribuye a su reactividad y posibles interacciones con varios objetivos biológicos. Además, se ha estudiado por sus posibles aplicaciones terapéuticas, incluyendo su papel en la modulación de vías de señalización relacionadas con la inflamación y el cáncer. Al igual que muchos compuestos naturales, se necesita más investigación para elucidar completamente sus mecanismos de acción y posibles usos clínicos.
Fórmula:C9H6O4
InChI:InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
Clave InChI:InChIKey=ATEFPOUAMCWAQS-UHFFFAOYSA-N
SMILES:OC1=C2C(=CC=C1O)C=CC(=O)O2
Sinónimos:- 2H-1-Benzopyran-2-one, 7,8-dihydroxy-
- 2H-1-benzopyran-2-one, 4,8-dihydroxy-
- 4,8-Dihydroxy-2H-chromen-2-one
- 7,8-Dihydroxy-2H-1-benzopyran-2-one
- 7,8-Dihydroxycoumarin
- 7,8-dihydroxy-2H-benzopyran-2-one
- 7,8-dihydroxy-2H-chromen-2-one
- Coumarin, 7,8-dihydroxy-
- Daphnetol
- NSC 633563
- Ruixiangsu
- Ver más sinónimos
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Encontrado 13 productos.
Daphnetin
CAS:Daphnetin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Fórmula:C9H6O4Pureza:(HPLC) ≥95%Forma y color:PowderPeso molecular:178.15Daphnetin
CAS:Fórmula:C9H6O4Pureza:>90.0%(HPLC)Forma y color:White to Light yellow to Light red powder to crystalPeso molecular:178.147,8-Dihydroxycoumarin
CAS:7,8-Dihydroxycoumarin is a naturally occurring coumarin, which is derived from plants and certain fungi. It possesses a distinct chemical structure characterized by a benzopyrone core with hydroxyl groups at the 7th and 8th positions, contributing to its distinct biochemical properties. The mode of action of 7,8-Dihydroxycoumarin is largely attributed to its ability to act as a potent antioxidant, scavenging free radicals and chelating metal ions, thus mitigating oxidative stress at the cellular level. In scientific research, 7,8-Dihydroxycoumarin is extensively studied for its potential as a therapeutic agent due to its diverse biological activities. It exhibits anti-inflammatory, antimicrobial, and anticoagulant properties, making it a valuable candidate for various biomedical applications. Additionally, its role in modulating enzyme activities and signaling pathways further broadens its scope in pharmacological studies. Researchers are keenly investigating its use in developing novel treatments for diseases associated with oxidative stress and inflammation. The precise mechanisms and broad applications of 7,8-Dihydroxycoumarin make it a subject of significant interest within the scientific community.Fórmula:C9H6O4Pureza:Min. 95%Forma y color:PowderPeso molecular:178.14 g/mol7,8-Dihydroxycoumarin (Daphnetin)
CAS:Fórmula:C9H6O4Pureza:(HPLC) ≥ 90.0%Forma y color:Off-white to light yellow or pink powderPeso molecular:178.14Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.142H-1-Benzopyran-2-one, 7,8-dihydroxy-
CAS:Fórmula:C9H6O4Pureza:90%Forma y color:SolidPeso molecular:178.14157,8-Dihydroxycoumarin, tech grade - 40%
CAS:7,8-Dihydroxycoumarin (7,8-DHC) is a natural compound that has been shown to inhibit the expression of the P-glycoprotein (Pgp) gene and protein. 7,8-DHC binds to the response element in the Pgp gene promoter and inhibits transcriptional activity. This inhibition of transcription prevents the production of new Pgp proteins, which leads to an increase in drug resistance. 7,8-DHC also has been shown to bind to bcl-2 protein in vitro and prevent its release from mitochondria. This prevents apoptosis by inhibiting mitochondrial membrane permeability. Coumarin derivatives have been shown as potential therapeutic agents for bowel diseases such as ulcerative colitis and Crohn's disease. Daphnetin, a coumarin derivative found in dandelion roots, has shown promise as a treatment for colitis in mice models.Fórmula:C9H6O4Pureza:(%) Min. 40%Forma y color:PowderPeso molecular:178.14 g/mol
