CAS 51-21-8: 5-Fluorouracilo
Descripción:
5-Fluorouracilo (5-FU) es un análogo de pirimidina sintético que actúa como un antimetabolito en el tratamiento del cáncer, dirigido principalmente a células que se dividen rápidamente. Su fórmula química es C4H3FN2O2, y se caracteriza por la presencia de un átomo de flúor en la posición 5 del anillo de uracilo, lo que altera sus vías metabólicas. El 5-FU se administra típicamente por vía intravenosa o tópica, dependiendo del tipo de cáncer que se esté tratando, como el cáncer colorrectal, de mama y de piel. El mecanismo de acción implica la inhibición de la timidilato sintasa, lo que lleva a una depleción de trifosfato de timidina y, en última instancia, interrumpe la síntesis y reparación del ADN. 5-Fluorouracilo es conocido por sus efectos secundarios, que pueden incluir trastornos gastrointestinales, mielosupresión y mucositis, debido a su impacto en las células normales que se dividen rápidamente. Su eficacia puede mejorarse cuando se utiliza en combinación con otros agentes quimioterapéuticos. Como un potente agente quimioterapéutico, el 5-FU sigue siendo un componente crítico en la farmacoterapia oncológica.
Fórmula:C4H3FN2O2
InChI:InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
Clave InChI:InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N
SMILES:O=C1C(F)=CNC(=O)N1
Sinónimos:- 1-fluoropyrimidine-2,4(1H,3H)-dione
- 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
- 2,4-Dihydroxy-5-fluoropyrimidine
- 2,4-Dioxo-5-fluoropyrimidine
- 5-Fluoracyl
- 5-Fluoro Uracil
- 5-Fluoro-1H-pyrimidine-2,4-dione
- 5-Fluoro-2,4(1H,3H)-pyrimidinedione
- 5-Fluoro-2,4-(1H,3H)-pyrimidindion
- 5-Fluoro-2,4-Pyrimidinedione
- 5-Fluoro-2,4-dihydroxypyrimidine
- Ver más sinónimos
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Fluorouracil
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFórmula:C4H3FN2O2Forma y color:White Off-White PowderPeso molecular:130.017865-Fluoro Uracil
CAS:Producto controladoImpurity Flucytosine EP Impurity A Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);Fórmula:C4H3FN2O2Forma y color:WhitePeso molecular:130.085-Fluorouracil, 99%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C4H3FN2O2Pureza:99%Forma y color:White to off-white, Crystalline powderPeso molecular:130.085-Fluorouracil - Bio-X ™
CAS:5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death. 5-Fluorouracil is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C4H3FN2O2Pureza:Min. 95%Forma y color:PowderPeso molecular:130.08 g/mol5-Fluorouracil
CAS:Fórmula:C4H3FN2O2Pureza:>99.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:130.085-Fluorouracil
CAS:5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis.Fórmula:C4H3FN2O2Pureza:100% - 99.98%Forma y color:White To Practically White Crystalline Powder Neoplastic Drug Chemosterilant For Insects (Epa 1998)Peso molecular:130.085-Fluorouracil
CAS:Fórmula:C4H3FN2O2Pureza:≥ 99.0%Forma y color:White to almost white crystalline powderPeso molecular:130.085-Fluorouracil
CAS:Thymidylate synthase inhibitor; anti-cancer drugFórmula:C4H3FN2O2Pureza:Min. 95%Forma y color:White PowderPeso molecular:130.08 g/mol5-Fluorouracil (5-FU) extrapure, 99%
CAS:Fórmula:C4H3FN2O2Pureza:min. 99%Forma y color:White to off white, Crystalline powder, Clear, ColourlessPeso molecular:130.085-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%
CAS:Fórmula:C4H3FN2O2Pureza:min. 99%Forma y color:White to off white, Crystalline powder, Clear, ColourlessPeso molecular:130.085-Fluorouracil, 99%
CAS:5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C4H3FN2O2Pureza:99%Forma y color:Crystalline powder, White to pale creamPeso molecular:130.08
