CAS 518048-05-0: Raltegravir
Descripción:
Raltegravir es un medicamento antirretroviral que se utiliza principalmente en el tratamiento de la infección por VIH. Pertenece a una clase de fármacos conocidos como inhibidores de la integrasa, que actúan bloqueando la enzima integrasa, impidiendo así la integración del ADN viral en el genoma de la célula huésped. Esta acción ayuda a inhibir la replicación viral. Raltegravir se caracteriza por su peso molecular relativamente bajo y una estructura química específica que incluye un núcleo de pirimidinona. Se administra típicamente por vía oral y es conocido por su perfil farmacocinético favorable, que incluye buena biodisponibilidad y un perfil de efectos secundarios manejable. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales y posibles efectos en la función hepática. Raltegravir se utiliza a menudo en combinación con otros agentes antirretrovirales para mejorar la eficacia del tratamiento y reducir el riesgo de desarrollo de resistencia. Su introducción ha mejorado significativamente las opciones de tratamiento para las personas que viven con VIH, contribuyendo a una mejor gestión de la enfermedad y a una mejor calidad de vida para los pacientes.
Fórmula:C20H21FN6O5
InChI:InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)
Clave InChI:InChIKey=CZFFBEXEKNGXKS-UHFFFAOYSA-N
SMILES:C(NC(=O)C1=NN=C(C)O1)(C)(C)C2=NC(C(NCC3=CC=C(F)C=C3)=O)=C(O)C(=O)N2C
Sinónimos:- 4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-
- 5-Hydroxy-2-[1-[[(5-Methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]-1-methylethyl]-N-(4-fluorobenzyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
- N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide
- N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide
- Raltegravir
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Encontrado 10 productos.
Raltegravir - Bio-X ™
CAS:Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. It inhibits the activity of HIV-1 integrase, which impedes the insertion of HIV-1 DNA into the host cell genome. Raltegravir also inhibits resistant mutants of HIV-1 that are associated with disease activity and progression. Raltegravir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C20H21FN6O5Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:444.42 g/molRaltegravir
CAS:Fórmula:C20H21FN6O5Pureza:≥ 99.0%Forma y color:White to off-white crystalline powderPeso molecular:444.42Raltegravir
CAS:Producto controladoApplications Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN. References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)Fórmula:C20H21FN6O5Forma y color:NeatPeso molecular:444.42Raltegravir
CAS:Raltegravir is an antiretroviral agent, which is a synthetic integrase inhibitor sourced from pharmaceutical research. Its mode of action involves the inhibition of the HIV-1 integrase enzyme, which is essential for the viral replication process. By blocking the strand transfer step of the integration of viral DNA into the host cell genome, Raltegravir prevents the proliferation of the virus within the host. The primary use of Raltegravir is in the treatment of HIV-1 infection in combination with other antiretroviral agents. It is an integral part of highly active antiretroviral therapy (HAART) and is crucial for the management of patients who require a potent antiretroviral response, particularly in cases where resistance to other treatments may be a concern. Raltegravir is also utilized in both initial treatment settings and for patients who have experienced therapeutic failures with other regimens. Its efficacy and safety profile make it a critical component in the ongoing battle against HIV/AIDS, offering hope for improved patient outcomes and quality of life.Fórmula:C20H21FN6O5Pureza:Min. 98 Area-%Forma y color:White Off-White PowderPeso molecular:444.42 g/molRaltegravir
CAS:Raltegravir (MK-0518) is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIVFórmula:C20H21FN6O5Pureza:100% - 99.86%Forma y color:SolidPeso molecular:444.42
