CAS 53-86-1: Indometacina
Descripción:
Indometacina es un fármaco antiinflamatorio no esteroideo (AINE) que se utiliza principalmente para aliviar el dolor, la hinchazón y la inflamación asociada con diversas condiciones, como la artritis y la gota. Se clasifica como un derivado del ácido indolacético y exhibe potentes propiedades antiinflamatorias y analgésicas. La fórmula química de Indometacina es C19H16ClN y tiene un peso molecular de aproximadamente 357.79 g/mol. Indometacina funciona inhibiendo las enzimas ciclooxigenasas (COX), que desempeñan un papel crucial en la síntesis de prostaglandinas, mediadores de la inflamación y el dolor. La sustancia se administra típicamente por vía oral, pero también se puede administrar por vía rectal o intravenosa. Indometacina es conocido por sus posibles efectos secundarios, que pueden incluir problemas gastrointestinales, riesgos cardiovasculares y deterioro renal, lo que requiere un monitoreo cuidadoso durante su uso. Su solubilidad es moderada en agua, pero es más soluble en disolventes orgánicos, lo que influye en su formulación en preparaciones farmacéuticas. En general, Indometacina sigue siendo un agente terapéutico importante en el manejo de condiciones inflamatorias.
Fórmula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Clave InChI:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Sinónimos:- 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
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Indometacin impurity mixture CRS
CAS:Indometacin impurity mixture CRSFórmula:C17H19N3Peso molecular:265.3529INDOMETACIN CRS
CAS:INDOMETACIN CRSFórmula:C17H19N3Forma y color:Crystalline Powder. White. Yellow. Powder.Peso molecular:265.3529Indomethacin
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C19H16ClNO4Forma y color:White to yellow to light beige, Crystalline powder, May have a pink huePeso molecular:357.79Indomethacin
CAS:Fórmula:C19H16ClNO4Pureza:≥ 98.0% (dried basis)Forma y color:White to off-white or pale pink powderPeso molecular:357.80Indomethacin
CAS:Producto controladoImpurity Acemetacin EP Impurity B Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)Fórmula:C19H16ClNO4Forma y color:BeigePeso molecular:357.79Indomethacin (Indometacin) EP Impurity D
CAS:Fórmula:C19H16ClNO4Forma y color:White To Off-White SolidPeso molecular:357.79Indomethacin - Bio-X ™
CAS:Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C19H16ClNO4Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:357.79 g/molIndomethacin
CAS:Analgesics, antipyretics and non-hormonal anti-inflammatory agentsFórmula:C19H16ClNO4Forma y color:PowderPeso molecular:357.79Indomethacin, 99+%
CAS:Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C19H16ClNO4Pureza:99+%Peso molecular:357.8Indomethacin, 98%
CAS:It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C19H16ClNO4Pureza:98%Forma y color:White to pale cream, PowderPeso molecular:357.79Indomethacin
CAS:Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.Fórmula:C19H16ClNO4Pureza:Min. 95%Forma y color:White PowderPeso molecular:357.79 g/molIndomethacin
CAS:Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.Fórmula:C19H16ClNO4Pureza:99.27% - 99.76%Forma y color:Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)Peso molecular:357.79Indomethacin
CAS:Fórmula:C19H16ClNO4Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:357.79
