CymitQuimica logo

CAS 53123-88-9: Rapamicina

Descripción:
Rapamicina, también conocido como sirolimus, es un compuesto macrólido con el número CAS 53123-88-9. Es producido por la bacteria *Streptomyces hygroscopicus* y es conocido principalmente por sus propiedades inmunosupresoras, lo que lo hace valioso en el trasplante de órganos para prevenir el rechazo. Rapamicina funciona inhibiendo el objetivo mamífero de Rapamicina (mTOR), un regulador clave del crecimiento celular, la proliferación y la supervivencia. Esta inhibición conduce a una reducción en la activación y proliferación de células T. Además de sus efectos inmunosupresores, Rapamicina ha atraído atención por sus potenciales propiedades anticancerígenas y su papel en la promoción de la longevidad en varios organismos modelo. El compuesto se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite efectos terapéuticos sostenidos. Sin embargo, puede tener efectos secundarios, incluyendo un mayor riesgo de infecciones, alteraciones metabólicas y potencial toxicidad pulmonar. Debido a su compleja farmacocinética, a menudo es necesario monitorear los niveles en sangre para optimizar la dosificación y minimizar los efectos adversos.
Fórmula:C51H79NO13
InChI:InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
Clave InChI:InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILES:O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]
Sinónimos:
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • 14S-Rapamycin
  • 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
  • 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • Antibiotic AY 22989
  • Ay 22989
  • Ver más sinónimos
Ordenar por

Encontrado 19 productos.
  • Ref: IN-DA0035KC

    1g
    111,00€
    5g
    284,00€
    10g
    518,00€
    25g
    A consultar
    10mg
    30,00€
    100mg
    39,00€
    250mg
    50,00€
    500mg
    75,00€
  • Rapamycin

    CAS:
    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    Fórmula:C51H79NO13
    Pureza:Min. 95 Area-%
    Forma y color:White Powder
    Peso molecular:914.17 g/mol

    Ref: 3D-AE27685

    1g
    728,00€
    2g
    988,00€
    5g
    1.863,00€
    250mg
    372,00€
    500mg
    530,00€
  • Rapamycin from Streptomyces hygroscopicus

    CAS:
    Rapamycin from Streptomyces hygroscopicus
    Fórmula:C51H79NO13
    Pureza:By hplc: 99.14% (Typical Value in Batch COA)
    Forma y color: white powder
    Peso molecular:914.17g/mol

    Ref: 54-BIR8101

    1g
    210,00€
    5g
    712,00€
    500mg
    128,00€
  • Sirolimus

    CAS:
    Fórmula:C51H79NO13

    Ref: TR-DRE-CA16970700

    10mg
    576,00€
  • Rapamycin (Sirolimus)

    CAS:
    Fórmula:C51H79NO13
    Forma y color:White To Off-White Solid
    Peso molecular:914.19

    Ref: 4Z-R-182

    5mg
    A consultar
    10mg
    A consultar
    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • Sirolimus

    CAS:
    Antibiotics nesoi
    Fórmula:C51H79NO13
    Forma y color:Off-White White Powder
    Peso molecular:913.55514

    Ref: 45-1612765

    50mg
    471,00€
  • Rapamycin-13C,d3 (contains d0) Technical Grade

    Producto controlado
    CAS:
    Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0. References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),
    Fórmula:C50CH76D3NO13
    Forma y color:Neat
    Peso molecular:918.18

    Ref: TR-R124003

    1mg
    689,00€
    5mg
    2.733,00€
    10mg
    5.029,00€
  • Rapamycin, 98+%

    CAS:
    Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
    Fórmula:C51H79NO13
    Pureza:98+%
    Forma y color:White to cream to yellow, Powder or crystals or crystalline powder
    Peso molecular:914.19

    Ref: 02-J62473

    50mg
    179,00€
    100mg
    231,00€
    200mg
    288,00€
  • Rapamycin-13C,d3 (contains d0) - Technical Grade

    Producto controlado
    CAS:
    Binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. Induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    Fórmula:C50CH76D3NO13
    Pureza:Min. 95%
    Peso molecular:918.18 g/mol

    Ref: 3D-BR177694

    1mg
    1.073,00€
    2mg
    1.694,00€
    5mg
    3.655,00€
  • Rapamycin

    CAS:
    Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.
    Fórmula:C51H79NO13
    Pureza:97.08% - 99.03%
    Forma y color:Yellow Solid
    Peso molecular:914.17

    Ref: TM-T1537

    1g
    283,00€
    10mg
    35,00€
    25mg
    48,00€
    50mg
    52,00€
    100mg
    69,00€
    200mg
    106,00€
    500mg
    188,00€
    1mL*10mM (DMSO)
    50,00€
  • Rapamycin

    CAS:
    Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's. References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),
    Fórmula:C51H79NO13
    Pureza:>85%
    Forma y color:Neat
    Peso molecular:914.17

    Ref: TR-R124000

    5mg
    130,00€
    50mg
    512,00€
    100mg
    876,00€
  • Sirolimus

    CAS:
    Forma y color:Neat

    Ref: 04-CA16970700

    10mg
    605,00€
  • Rapamycin

    CAS:
    M02444 - Rapamycin
    Fórmula:C51H79NO13
    Pureza:98%
    Forma y color:Solid, Crystalline Powder or Granules or Powder
    Peso molecular:914.187

    Ref: 10-M02444

    1g
    102,00€
    5g
    408,00€
    10mg
    24,00€
    50mg
    31,00€
    100mg
    34,00€
    250mg
    96,00€
    500mg
    91,00€
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:>98.0%(HPLC)
    Forma y color:White to Almost white powder to crystal
    Peso molecular:914.19

    Ref: 3B-R0097

    25mg
    83,00€
  • Rapamycin - Bio-X ™

    CAS:
    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells. Rapamycin - Bio-X ™ is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
    Fórmula:C51H79NO13
    Pureza:Min. 95%
    Forma y color:Powder
    Peso molecular:914.17 g/mol

    Ref: 3D-BR164324

    10mg
    140,00€
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:98.0 - 102.0 % (anhydrous basis)
    Forma y color:White to yellow crystalline powder
    Peso molecular:914.17

    Ref: 7W-GA7417

    5mg
    33,00€
    25mg
    79,00€
    50mg
    148,00€
    100mg
    243,00€
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:95%~99%
    Peso molecular:914.187

    Ref: BP-BP1196

    ne
    A consultar
  • Rapamycin

    CAS:
    Rapamycin
    Pureza:≥98%
    Peso molecular:914.17g/mol

    Ref: 54-BUP17166

    10mg
    53,00€
    25mg
    64,00€
    50mg
    76,00€
    100mg
    96,00€
    200mg
    163,00€
    500mg
    273,00€
  • Everolimus EP Impurity A

    CAS:
    Fórmula:C51H79NO13
    Peso molecular:914.2

    Ref: ST-EA-CP-E33001

    10mg
    A consultar
    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar