CAS 54965-24-1: Citrato de tamoxifeno
Descripción:
Citrato de tamoxifeno es un modulador selectivo del receptor de estrógeno (SERM) no esteroideo que se utiliza principalmente en el tratamiento del cáncer de mama positivo para receptores de estrógeno. Funciona al unirse a los receptores de estrógeno, inhibiendo así los efectos del estrógeno en el tejido mamario, lo que puede promover el crecimiento de ciertos tipos de tumores mamarios. El compuesto se administra típicamente por vía oral y es conocido por su capacidad para reducir el riesgo de recurrencia del cáncer de mama. Citrato de tamoxifeno se caracteriza por su fórmula química, que incluye una estructura fenólica, y exhibe propiedades tanto estrogénicas como antiestrogénicas dependiendo del tejido objetivo. Su farmacocinética implica un extenso metabolismo hepático, lo que lleva a metabolitos activos que contribuyen a sus efectos terapéuticos. Los efectos secundarios comunes pueden incluir sofocos, náuseas y un mayor riesgo de eventos tromboembólicos. Debido a su papel significativo en oncología, Citrato de tamoxifeno sigue siendo un pilar en los protocolos de tratamiento del cáncer de mama y también se investiga para su posible uso en otras condiciones influenciadas por el estrógeno.
Fórmula:C26H29NO·C6H8O7
InChI:InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
Clave InChI:InChIKey=FQZYTYWMLGAPFJ-OQKDUQJOSA-N
SMILES:C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3.C(CC(O)=O)(CC(O)=O)(C(O)=O)O
Sinónimos:- (Z)-2-[4-(1,2-Diphenyl-1-Butenyl)Phenoxyl]-N,N-Dimethyl-Ethanamine-Citrate
- 1-P-Beta-Dimethylaminoethoxyphenyl-Trans-1,2-Diphenylbut-1-Ene Citrate
- 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
- Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Genox
- I.C.I.46474 citrate
- Ici 46474
- Istubal
- Kessar
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Encontrado 20 productos.
TAMOXIFEN CITRATE RS
CAS:TAMOXIFEN CITRATE RSFórmula:C32H37NO8Forma y color:PowderPeso molecular:563.6381TAMOXIFEN CITRATE FOR PERFORMANCE TEST CRS
CAS:TAMOXIFEN CITRATE FOR PERFORMANCE TEST CRSFórmula:C32H37NO8Forma y color:PowderPeso molecular:563.6381Tamoxifen Citrate
CAS:Producto controladoFórmula:C26H29NO·C6H8O7Forma y color:NeatPeso molecular:563.64Tamoxifen citrate
CAS:Producto controladoFórmula:C26H29NO·C6H8O7Forma y color:NeatPeso molecular:563.64Tamoxifen citrate
CAS:Please enquire for more information about Tamoxifen citrate including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C32H37NO8Pureza:Min. 98.0 Area-%Peso molecular:563.64 g/molRef: 3D-Q-201776
5gA consultar10gA consultar25gA consultar50gA consultar100gA consultar-Unit-ggA consultarTamoxifen Citrate
CAS:Aromatic drugs of amino-alcohols, other than those contg > one kind of oxygen function, their ethers and esters; salts thereof, nesoiFórmula:C26H29NO·C6H8O7Forma y color:White Off-White Crystalline PowderPeso molecular:563.25192Tamoxifen Citrate
CAS:Fórmula:C26H29NO·C6H8O7Pureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:563.65Tamoxifen citrate
CAS:Producto controladoEstrogen receptor modulator; protein kinase C inhibitorFórmula:C26H29NO·C6H8O7Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:563.64 g/molTamoxifen citrate
CAS:Tamoxifen citrateFórmula:C26H29NOPureza:65.8%Forma y color:WhitePeso molecular:371.22491Tamoxifen citrate
CAS:Tamoxifen citratePureza:99%Forma y color:Off-White SolidPeso molecular:563.64g/molTamoxifen Citrate
CAS:Fórmula:C26H29NO·C6H8O7Forma y color:White To Off-White SolidPeso molecular:371.53 192.13Tamoxifen citrate, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C32H37NO8Pureza:98%Forma y color:White to off-white, PowderPeso molecular:563.65Tamoxifen citrate salt
CAS:Fórmula:C26H29NO·C6H8O7Pureza:≥ 98.0%Forma y color:White to almost white powderPeso molecular:563.65Tamoxifen Citrate
CAS:Producto controladoApplications Tamoxifen Citrate is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. References Sutherland, R., et al.: Nature, 267, 434 (1977), Lerner, L., et al.: Cancer Res., 50, 4177 (1990), Love, R., et al.: J. Clin. Oncol., 20 2559 (2002),Fórmula:C26H29NO·C6H8O7Forma y color:WhitePeso molecular:563.64Tamoxifen Citrate
CAS:Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).Fórmula:C32H37NO8Pureza:99.86%Forma y color:White To Off-White White To Off-White PowderPeso molecular:563.65Tamoxifen citrate
CAS:Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C26H29NO·C6H8O7Peso molecular:563.65
