CAS 62996-74-1: Estaurosporina
Descripción:
Estaurosporina es un potente alcaloide derivado de la bacteria Streptomyces staurosporeus, conocido por sus efectos inhibitorios de amplio espectro sobre las quinasas. Se caracteriza por su compleja estructura tetracíclica, que contribuye a su actividad biológica. Estaurosporina exhibe una alta afinidad por varias quinasas, incluidas las involucradas en las vías de señalización celular, lo que lo convierte en una herramienta valiosa en la investigación para estudiar procesos celulares como la apoptosis y la proliferación celular. El compuesto se utiliza típicamente en entornos de laboratorio para investigar los mecanismos del cáncer y otras enfermedades. Estaurosporina también es reconocido por sus posibles aplicaciones terapéuticas, aunque su uso está limitado debido a su naturaleza no selectiva y la toxicidad asociada. En términos de propiedades físicas, es un sólido cristalino que es soluble en disolventes orgánicos pero tiene una solubilidad limitada en agua. Como sustancia química de investigación, es importante manejar Estaurosporina con cuidado, cumpliendo con los protocolos de seguridad debido a sus potentes efectos biológicos.
Fórmula:C28H26N4O3
InChI:InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Clave InChI:InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N
SMILES:C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8
Sinónimos:- (5R,6S,7S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
- (5R,6S,7S,9S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
- (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
- (5S,6R,7R,9R)-6-methoxy-N,5-dimethyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-aminium
- (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
- 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
- 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
- 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
- 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
- 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
- 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
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Encontrado 17 productos.
Staurosporine
CAS:Fórmula:C28H26N4O3Pureza:(HPLC) ≥ 98.0%Forma y color:Off-white to yellow solidPeso molecular:466.54Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.98%Forma y color:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg62,00€2mg87,00€5mg97,00€10mg145,00€25mg246,00€50mg401,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)109,00€Staurosporine
CAS:Fórmula:C28H26N4O3Pureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:466.54Staurosporine, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C28H26N4O3Pureza:98%Forma y color:White to light yellow to light beige, PowderPeso molecular:466.54Staurosporine, 99+%
CAS:Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C28H26N4O3Pureza:99+%Forma y color:Crystalline powder or granular, White to pale cream to yellowPeso molecular:466.54Staurosporine
CAS:Staurosporine is a fluorogenic substrate for the enzyme staurosporinase that is used in food testing, environmental testing, and diagnostics. It can be conjugated to an antibody or other protein to produce a ligand that binds to a receptor on the cell surface. Staurosporine has been shown to inhibit the activity of various enzymes including phospholipase A2, phospholipase C, and protein kinase C. It also inhibits bacterial DNA gyrase and topoisomerase IV. The fluorescence of staurosporine can be detected with luminometers or fluorescent microscopes.Fórmula:C28H26N4O3Pureza:Min. 95%Peso molecular:466.53 g/molStaurosporin
CAS:Producto controladoApplications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types. References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),Fórmula:C28H26N4O3Forma y color:NeatPeso molecular:466.53Staurosporine
CAS:Producto controladoInhibitor of protein kinases; induces apoptosis; anti-cancerFórmula:C28H26N4O3Pureza:Min. 98 Area-%Forma y color:Off-White PowderPeso molecular:466.53 g/molStaurosporine, from Streptomyces sp.
CAS:Staurosporine, from Streptomyces sp.Fórmula:C28H26N4O3Pureza:By hplc: 99.22% (Typical Value in Batch COA)Forma y color: off-white powderPeso molecular:466.53g/mol
