CAS 64-86-8: Colchicina
Descripción:
Colchicina es un potente alcaloide derivado de la planta Colchicum autumnale, comúnmente conocida como el crocus de otoño. Se caracteriza por su capacidad para inhibir la polimerización de microtúbulos, lo que interrumpe la mitosis celular y se utiliza principalmente en el tratamiento de la gota y la fiebre mediterránea familiar. Colchicina aparece como un polvo cristalino blanco a blanco sucio y es soluble en agua, alcohol y cloroformo, pero poco soluble en éter. Su fórmula química es C22H25NO6 y tiene un peso molecular de aproximadamente 399.44 g/mol. Colchicina exhibe propiedades antiinflamatorias y también se estudia por sus posibles efectos en diversas enfermedades, incluidas las condiciones cardiovasculares y ciertos cánceres. Sin embargo, tiene una ventana terapéutica estrecha, lo que significa que la diferencia entre una dosis efectiva y una dosis tóxica es pequeña, lo que requiere un monitoreo cuidadoso durante su uso. Los efectos adversos pueden incluir trastornos gastrointestinales, supresión de la médula ósea y neuropatía periférica, lo que hace esencial que los pacientes estén bajo supervisión médica al usar este compuesto.
Fórmula:C22H25NO6
InChI:InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
Clave InChI:InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N
SMILES:O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3
Sinónimos:- (-)-Colchicine
- (S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
- (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
- Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
- Benzo[a]heptalene, acetamide deriv.
- Colchicin
- Colchicina
- Colchicine Fu
- Colchineos
- Colchisol
- Colcin
- Ver más sinónimos
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Colchicine for system suitability A CRS
CAS:Colchicine for system suitability A CRSForma y color:PowderColchicine
CAS:Fórmula:C22H25NO6Pureza:≥ 95.0% (dried, solvent-free basis)Forma y color:White to yellow powderPeso molecular:399.44Colchicine (contains 5% Ethyl Acetate at maximum)
CAS:Fórmula:C22H25NO6Pureza:>97.0%(HPLC)Forma y color:White to Orange to Green powder to crystalPeso molecular:399.44Colchicine, 98%
CAS:Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C22H25NO6Pureza:98%Forma y color:Powder, White to pale yellowPeso molecular:399.44Colchicine
CAS:Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding toFórmula:C22H25NO6Pureza:98% - 99.96%Forma y color:Pale Yellow Scales Or Powder; Pale Yellow Needles When Crystallized From Ethyl Acetate To Light Used To Treat Gouty Arthritis Pseudogout Sarcoidal Arthritis And Calcific Tendinitis (EpaPeso molecular:399.44Colchicine, 97%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C22H25NO6Pureza:97%Forma y color:Light yellow, PowderPeso molecular:399.44Colchicine
CAS:Used as gout medication; anti-inflammatoryFórmula:C22H25NO6Pureza:Min. 94 Area-%Forma y color:White PowderPeso molecular:399.44 g/molColchicine extrapure, 98%
CAS:Fórmula:C22H25NO6Pureza:min. 98%Forma y color:White to yellow, Crystalline compound, Clear, Colourless to pale yellow, Clear, Colourless to pale yellowPeso molecular:399.45Colchicine, 95% (dry wt.)
CAS:Colchicine is used as an anti-inflammatory agent for long-term treatment of behcet's Disease. It is used for constipation-predominant irritable bowel syndrome in women, and for treatment of severe or persistent aphthous stomatitis (canker sores).This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C22H25NO6Pureza:95%Forma y color:White to pale cream to pale yellow, PowderPeso molecular:399.44Colchicine ExiPlus, Multi-Compendial, 98%
CAS:Fórmula:C22H25NO6Pureza:min. 98%Forma y color:White to yellow, Crystalline compound, Clear, Colourless to pale yellow, Clear, Colourless to pale yellowPeso molecular:399.45Colchicine
CAS:Natural alkaloidFórmula:C22H25NO6Pureza:≥ 95.0 % (HPLC)Forma y color:PowderPeso molecular:399.44Colchicine for tissue culture, 98%
CAS:Fórmula:C22H25NO6Pureza:min. 98%Forma y color:White to yellow, Crystalline compound, Clear, Colourless to pale yellow, Clear, Colourless to pale yellowPeso molecular:399.45Colchicine, USP grade
CAS:Fórmula:C22H25NO6Pureza:≤ 5.0%Forma y color:White to yellow powderPeso molecular:399.44Colchicine
CAS:Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoiFórmula:C22H25NO6Forma y color:Light Yellow Light Green Crystalline Powder Amorphous PowderPeso molecular:399.44
