CAS 70288-86-7: Ivermectina
Descripción:
Ivermectina es un agente antiparasitario de amplio espectro utilizado principalmente en medicina veterinaria y salud humana para el tratamiento de diversas infecciones parasitarias. Pertenece a la clase de lactonas macrocíclicas y se deriva de la bacteria Streptomyces avermitilis. El compuesto exhibe una estructura compleja caracterizada por un gran anillo de lactona y múltiples estereocentros, lo que contribuye a su actividad biológica. Ivermectina actúa uniéndose a los canales de cloruro activados por glutamato en las células nerviosas y musculares de los parásitos, lo que lleva a la parálisis y muerte del organismo. Es efectivo contra una variedad de parásitos, incluidos los que causan ceguera de río, filariasis linfática y sarna. Ivermectina generalmente es bien tolerado, con un perfil de seguridad favorable, aunque pueden ocurrir efectos secundarios, particularmente en casos de alta carga parasitaria. Su uso se ha expandido más allá de las aplicaciones tradicionales, con investigaciones en curso que exploran sus posibles propiedades antivirales. El compuesto se administra típicamente por vía oral o tópica, dependiendo del tipo de infección que se esté tratando.
Fórmula:Unspecified
InChI:InChI=1/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25?,26-,28-,30-,31-,33+,34?,35-,36-,37-,38?,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33?,34-,35-,36-,37?,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1
Sinónimos:- 22,23-Dihydroavermectin
- 22,23-Dihydroavermectin B1
- 22,23-Dihydroavermectin B<sub>1</sub>
- Bagomectina
- Bimectin
- Bovinet
- Cardomec
- Cardotek 30
- Cardotek Plus
- Cevamec
- Equimec
- Ver más sinónimos
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Ivermectin
CAS:Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.Fórmula:C48H74O14Pureza:94.11% - 97.74%Forma y color:SolidPeso molecular:875.09Ivermectine
CAS:Producto controladoFórmula:C48H74O14·C47H72O14Forma y color:NeatPeso molecular:1736.16Ivermectin
CAS:IvermectinFórmula:C48H74O14Pureza:87.6%Forma y color:White To Off-WhitePeso molecular:874.50786Ivermectin
CAS:Producto controladoApplications Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Anthelmintic (Onchocerca). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);Fórmula:C48H74O14·C47H72O14Forma y color:White To Off-WhitePeso molecular:1736.16Ivermectin
CAS:Lactones, nesoiFórmula:H2B1a(C48H74O14)H2B1b(C47H72O14)Forma y color:White Light Yellow Crystalline PowderSmart Solutions™ v59 PharmaVetResiMix Kit 1
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Forma y color:MixtureIvermectin
CAS:It is used as a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C95H146O28Forma y color:Powder, White to pale creamPeso molecular:1736.19Ivermectin - Bio-X ™
CAS:Naturally produced by the soil bacterium Streptomyces avermitili, Ivermectin is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, research indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins. Ivermectin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C48H74O14Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:875.09 g/molIvermectin
CAS:Fórmula:C48H74O14Pureza:>93.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:875.11Ivermectin-d2
CAS:Producto controladoApplications Isotope labelled Ivermectin, is the labeled analogue of Ivermectin (I940800), which is a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980), Campbell, W.C., et al.: Science, 221, 823 (1983), Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988), Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995), ; Caly, L., et al.: Antivir. Res., 178Fórmula:C48H72D2O14Forma y color:White To BeigePeso molecular:877.11Ivermectin (IVM), 95-102%
CAS:Fórmula:C48H74O14Pureza:min. 95 - 102%Forma y color:White to off-white, Crystalline powderPeso molecular:875.10Ivermectin
CAS:Fórmula:C48H74O14(H2B1a)Pureza:≥ 95.0% (dry basis, H2B1a + H2B1b)Forma y color:White to light-yellow crystalline powderPeso molecular:875.11 (H2B1a)LC PestiMix 4 10 µg/mL in Acetonitrile
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Forma y color:MixtureGB 23200.121-2021 Pesticide Mixture 8 50 µg/mL in Acetonitrile:Methanol
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Forma y color:Mixture
