CAS 73573-88-3: Mevastatina
Descripción:
Mevastatina, también conocido como compactina, es una estatina que ocurre de forma natural y que se utiliza principalmente por sus propiedades para reducir el colesterol. Se deriva de la fermentación de ciertos hongos, particularmente Penicillium citrinum. La estructura química de Mevastatina presenta un anillo de lactona y un grupo ácido hidroxílico, que son cruciales para su actividad biológica. Como inhibidor de la HMG-CoA reductasa, Mevastatina desempeña un papel significativo en la vía del mevalonato, reduciendo efectivamente la síntesis de colesterol en el hígado. Esta acción ayuda a disminuir los niveles de colesterol de lipoproteínas de baja densidad (LDL) en el torrente sanguíneo, reduciendo así el riesgo de enfermedades cardiovasculares. Mevastatina se administra típicamente en su forma activa, que es el ácido hidroxílico, ya que la forma de lactona se convierte en la forma activa en el cuerpo. Aunque se ha utilizado en investigación y tiene una importancia histórica en el desarrollo de medicamentos estatinas, su uso clínico ha sido en gran medida reemplazado por estatinas más potentes y ampliamente estudiadas. Al igual que con todos los medicamentos, se deben considerar los posibles efectos secundarios e interacciones al evaluar su uso.
Fórmula:C23H34O5
InChI:InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
Clave InChI:InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N
SMILES:C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@]3([C@@H](OC([C@H](CC)C)=O)CCC=C3C=C[C@@H]2C)[H]
Sinónimos:- (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
- 2-Methyl-butanoic acid [1S-[1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
- Antibiotic ML 236B
- Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
- Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),7β,8β(2S*,4S*),8aβ]]-
- CS 500 (antibiotic)
- Compactin (Penicillium)
- Cs 500
- L 637312
- ML 236B lactone
- Mevastatin
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Encontrado 19 productos.
Mevastatin
CAS:Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity. In addition, it has been shown to induce neuronal death in a polymerase chain reaction assay by inhibiting DNA synthesis.Fórmula:C23H34O5Pureza:Min. 95%Forma y color:PowderPeso molecular:390.51 g/molButanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
CAS:Fórmula:C23H34O5Pureza:95%Forma y color:SolidPeso molecular:390.5131Mevastatin, 98%
CAS:Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C23H34O5Pureza:98%Forma y color:Powder or crystals or crystalline powderPeso molecular:390.52Mevastatin
CAS:Fórmula:C23H34O5Pureza:≤ 0.5%Forma y color:White to light-yellow crystalline powderPeso molecular:390.52Mevastatin (Compactin)
CAS:Fórmula:C23H34O5Forma y color:White To Off-White SolidPeso molecular:390.52Mevastatin
CAS:Producto controladoApplications A fungal metabolite which is a potent inhibitor of HMG-CoA reductase. References Endo, A., et al.: FEBS Letters, 72, 323 (1976), Endo, A.: J. Med. Chem., 28, 401 (1985)Fórmula:C23H34O5Forma y color:White To Off-WhitePeso molecular:390.51Mevastatin
CAS:Fórmula:C23H34O5Pureza:>98.0%(HPLC)Forma y color:White to Yellow to Orange powder to crystalPeso molecular:390.52Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Forma y color:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Mevastatin ((1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate)
CAS:Lactones, nesoiFórmula:C23H34O5Forma y color:Yellow Pale Yellow PowderPeso molecular:390.24062Mevastatin - Bio-X ™
CAS:Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity. Mevastatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C23H34O5Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:390.51 g/molMevastatin
CAS:M02108 - MevastatinFórmula:C23H34O5Pureza:>95%Forma y color:SolidPeso molecular:390.5199890136719Ref: 10-M02108
1g17,00€5g25,00€25g67,00€100g156,00€500g472,00€50mg17,00€100mg17,00€250mgA consultar500mg17,00€
