CAS 751-97-3: Rolitetraciclina
Descripción:
Rolitetraciclina es un antibiótico de amplio espectro que pertenece a la clase de las tetraciclinas, caracterizado por su capacidad para inhibir la síntesis de proteínas bacterianas. Se deriva del producto natural clortetraciclina y exhibe un mecanismo de acción similar al unirse a la subunidad ribosomal 30S, impidiendo así la unión de aminoacil-tRNA al ribosoma. Este antibiótico es efectivo contra una variedad de bacterias grampositivas y gramnegativas, lo que lo hace útil en el tratamiento de diversas infecciones. Rolitetraciclina se administra típicamente por vía oral y es conocido por su relativamente buena absorción y distribución en el cuerpo. Su estructura química presenta un núcleo de naftaceno con múltiples grupos hidroxilo y dimetilamino, lo que contribuye a su solubilidad y actividad biológica. Sin embargo, al igual que otras tetraciclinas, puede causar efectos secundarios como trastornos gastrointestinales y fotosensibilidad. Además, su uso está limitado en ciertas poblaciones, como mujeres embarazadas y niños pequeños, debido a posibles efectos adversos en el desarrollo de huesos y dientes. En general, Rolitetraciclina sigue siendo un agente importante en el arsenal contra las infecciones bacterianas, particularmente en casos donde la resistencia a otros antibióticos es una preocupación.
Fórmula:C27H33N3O8
InChI:InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
Clave InChI:InChIKey=HMEYVGGHISAPJR-IAHYZSEUSA-N
SMILES:O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(NCN3CCCC3)=O)C1=O)(C[C@]4(C(=C2O)C(=O)C=5C([C@@]4(C)O)=CC=CC5O)[H])[H]
Sinónimos:- (2Z,4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(pyrrolidin-1-ylmethyl)amino]methylidene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
- (2Z,4S,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(pyrrolidin-1-ylmethyl)amino]methylidene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
- (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide
- (4S,4aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-, (4S,4aS,5aS,6S,12aS)-
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-, [4S-(4α,4aα,5aα,6β,12aα)]-
- 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide
- 4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
- Abricycline
- Bristacin
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Encontrado 4 productos.
Rolitetracycline
CAS:Rolitetracycline is a semi-synthetic tetracycline antibiotic, which is derived from the natural compound tetracycline. It functions primarily by inhibiting protein synthesis in susceptible bacteria. This is achieved through the binding to the 30S ribosomal subunit, effectively blocking the attachment of aminoacyl-tRNA to the mRNA-ribosome complex, thereby preventing the addition of new amino acids to the nascent peptide chain. As a result, bacterial cell growth is inhibited, leading to bacteriostatic effects. The primary use of Rolitetracycline is in the treatment of various bacterial infections, particularly those caused by Gram-positive and Gram-negative organisms. Its applications extend to the management of respiratory tract infections, urinary tract infections, and certain skin infections. Due to its broad-spectrum activity, it can be employed in situations where the causative organism is unknown, provided the risk of resistance and other factors are considered. The synthesis and subsequent modifications of Rolitetracycline are part of ongoing efforts in antibiotic research to combat resistant bacterial strains where traditional tetracyclines might fail.Fórmula:C27H33N3O8Pureza:Min. 95%Forma y color:PowderPeso molecular:527.57 g/molRolitetracycline (Technical Grade)
CAS:Producto controladoApplications Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable. References Choudhary, S., et al.: Chem. Biol. Drug. Des., 80, 693 (2012); Ejim, L., et al.: Nature. Chem. Biol., 7, 348 (2011); Giorgetti, S., et al.: J. Biol. Chem., 286, 2121 (2011);Fórmula:C27H33N3O8Forma y color:Dark Red To Dark BrownPeso molecular:527.57Rolitetracycline
CAS:Fórmula:C27H33N3O8Pureza:≥ 98.0%Forma y color:Yellow to orange or red solidPeso molecular:527.57Rolitetracycline Trifluoroacetate
CAS:Fórmula:C27H33N3O8·C2HF3O2Forma y color:Yellow SolidPeso molecular:527.57 114.02
