CAS 75567-37-2: Ingenol mebutato
Descripción:
Ingenol mebutato es un compuesto sintético derivado de la savia de la planta Euphorbia peplus, conocido por su uso en aplicaciones dermatológicas, particularmente en el tratamiento de la queratosis actínica. Se clasifica como un diterpenoide y exhibe un mecanismo de acción único que implica inducir la muerte celular en queratinocitos anormales mientras también promueve una respuesta inflamatoria que ayuda en la eliminación de estas células. Ingenol mebutato se formula típicamente como un gel tópico, lo que permite un tratamiento localizado. El compuesto tiene una vida media relativamente corta, lo que contribuye a su perfil de seguridad, ya que la absorción sistémica es mínima. Su eficacia se atribuye a su capacidad para activar la proteína quinasa C, lo que lleva a la apoptosis y a respuestas inmunitarias mediadas posteriormente. Ingenol mebutato generalmente es bien tolerado, aunque algunos pacientes pueden experimentar reacciones cutáneas locales como eritema, costras o descamación. En general, representa un enfoque novedoso en el manejo de lesiones cutáneas precoces, proporcionando una opción conveniente y efectiva para los pacientes.
Fórmula:C25H34O6
InChI:InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
Clave InChI:InChIKey=VDJHFHXMUKFKET-WDUFCVPESA-N
SMILES:O[C@@]12[C@@]3(C(=O)[C@]([C@]4([C@@](C[C@H]3C)(C4(C)C)[H])[H])(C=C(CO)[C@H]1O)[H])C=C(C)[C@@H]2OC(/C(=C\C)/C)=O
Sinónimos:- 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecene, 2-butenoic acid deriv.
- 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-
- 2-Butenoic acid, 2-methyl-, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, [1aR-[1aα,2β,5β,5aβ,6β(Z),8aα,9α,10aα]]-
- 3-Angeloylingenol
- Aids-416619
- Aids416619
- Euphorbia factor An<sub>1</sub>
- Euphorbia factor H<sub>1</sub>
- I3A
- Ingenol 3-angelate
- Ingenol 3-mebutate
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Encontrado 9 productos.
Ingenol 3-Angelate
CAS:Producto controladoApplications Ingenol 3-Angelate is known to exhibit antitumor activities which induces plasma membrane and mitochondrial disruption and necrotic cell death. References Ogbourne, S.M., et al.: Cancer. Res., 64, 2833 (2004); Zayed, S.M., et al.: J. Cancer. Res. Clin. Oncol., 127, 40 (2001);Fórmula:C25H34O6Forma y color:NeatPeso molecular:430.53Ingenol mebutate
CAS:Ingenol mebutate activates PKC-α, -β, -γ, -δ, -ε (Kis 0.105-0.376 nM), has anti-inflammatory and antitumor effects.Fórmula:C25H34O6Pureza:99.04%Forma y color:SolidPeso molecular:430.53Ref: TM-TN1047
1mg70,00€2mg97,00€5mg198,00€10mg331,00€25mg548,00€50mgA consultar1mL*10mM (DMSO)187,00€Ingenol Mebutate
CAS:Ingenol-3-angelate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of ingenol-3-angelate in vivo; it activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCdelta. Ingenol-3-angelate suppresses HIV infection of primary CD4+ T cells through down-modulation of cell surface expression of HIV co-receptors. Ingenol-3-angelate emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases.Fórmula:C25H34O6Pureza:95%~99%Peso molecular:430.541Ingenol-3-angelate
CAS:Ingenol-3-angelate (ING) is a natural compound that induces apoptosis in cancer cells by inhibiting mitochondrial membrane potential and the production of ATP. It also has been shown to be an active antiretroviral therapy that inhibits HIV replication in T cells. Ingenol-3-angelate has significant cytotoxicity against k562 cells, which can be enhanced by laser ablation. The drug is metabolized to mebutate, which is the only known active form of ING. Mebutate binds to the polymerase chain reaction enzyme DNA polymerase and prevents its activity, thus inhibiting DNA synthesis and replication. Ingenol-3-angelate also has drug interactions with other drugs such as cyclosporin A and tacrolimus, which inhibit or induce cytochrome P450 enzymes.Fórmula:C25H34O6Pureza:Min. 95%Forma y color:White To Off-White SolidPeso molecular:430.53 g/molRef: 3D-FI29384
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