CAS 80-08-0: Dapsona
Descripción:
Dapsona, con el número CAS 80-08-0, es un antibiótico sulfonamida aromático utilizado principalmente en el tratamiento de la lepra y ciertos tipos de dermatitis, como la dermatitis herpetiforme. Es un polvo cristalino blanco a blanco amarillento que es ligeramente soluble en agua y más soluble en disolventes orgánicos como el etanol y la acetona. Dapsona funciona inhibiendo la síntesis de folato bacteriano, ejerciendo así sus efectos antimicrobianos. Su fórmula química es C12H12N2O2S, y tiene un peso molecular de aproximadamente 240.3 g/mol. Dapsona es conocido por sus propiedades antiinflamatorias, lo que lo hace efectivo en el tratamiento de condiciones autoinmunes de la piel. Aunque generalmente es bien tolerado, puede causar efectos secundarios como anemia hemolítica, especialmente en individuos con deficiencia de glucosa-6-fosfato deshidrogenasa. Se recomienda el monitoreo de los parámetros sanguíneos durante el tratamiento. Dapsona se utiliza a menudo en combinación con otros medicamentos para mejorar la eficacia terapéutica y reducir el riesgo de resistencia.
Fórmula:C12H12N2O2S
InChI:InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
Clave InChI:InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=CC=C(N)C=C1)C2=CC=C(N)C=C2
Sinónimos:- 1,1'-Sulfonylbis[4-aminobenzene]
- 1358F
- 4,4'-Dapsone
- 4,4'-Dds
- 4,4'-Diamino Diphenyl Sulfone
- 4,4'-Diamino Diphenyl Sulphone
- 4,4'-Diaminodiphenylsulfon
- 4,4'-Diaminodiphenylsulfone
- 4,4'-Sulfonylbisaniline
- 4,4'-Sulfonylbisbenzamine
- 4,4'-Sulfonyldiphenylamine
- Ver más sinónimos
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Dapsone
CAS:Other aromatic organo-sulfur compounds (excluding pesticides)Fórmula:C12H12N2O2SForma y color:White Off-White Light Yellow Crystalline PowderPeso molecular:248.06195Dapsone
CAS:Producto controladoApplications An antibacterial used in the treatment of dermatitis herpetiformis. References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),Fórmula:C12H12N2O2SForma y color:NeatPeso molecular:248.30Di-(4-(4'-Aminidiphenylsulphone))amine
CAS:Producto controladoFórmula:C24H21N3O4S2Forma y color:NeatPeso molecular:479.571Dapsone
CAS:Dapsone is a nonsteroidal anti-inflammatory drug that is used to treat various types of infectious diseases and skin disorders. It acts by blocking the synthesis of dihydrofolic acid, which leads to inhibition of bacterial growth. Dapsone inhibits the activity of monoethyl ether reductase (NADH) in human polymorphonuclear leukocytes, which slows the production of hydrogen peroxide and prevents oxidative damage to cellular components. It has been shown to be effective against both erythema multiforme and chronic dermatitis herpetiformis with minimal side effects. The use of dapsone may be helpful in diagnosis as it can inhibit polymerase chain reactions that are specific for squamous cells. There are also reports that dapsone may affect intestinal motility and cause bowel disease.Fórmula:C12H12N2O2SPureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:248.3 g/mol4,4'-Diaminodiphenyl sulfone, 98%
CAS:It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Moreover it is employed as an anti-inflammatory drug, anti-infective drug, a leprostatic drug and an antimalarial drug. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C12H12N2O2SPureza:98%Forma y color:White to pale cream, PowderPeso molecular:248.30Dapsone
CAS:Fórmula:C12H12N2O2SPureza:(Titration) 98.0 - 102.0 %Forma y color:White to off-white crystalline powderPeso molecular:248.304-Aminophenyl sulfone, 97%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C12H12N2O2SPureza:97%Forma y color:Crystalline powder, White to beigePeso molecular:248.304-[(4-aminobenzene)sulfonyl]aniline
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:248.3000030517578Dapsone
CAS:Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Fórmula:C12H12N2O2SPureza:99.84%Forma y color:White To Creamy Solid CrystallinePeso molecular:248.3Bis(4-aminophenyl) Sulfone
CAS:Bis(4-aminophenyl) SulfoneFórmula:C12H12N2O2SPureza:97%Forma y color: off-white solidPeso molecular:248.30g/mol
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