CAS 80474-14-2: Propionato de fluticasona
Descripción:
Propionato de fluticasona es un corticosteroide sintético con propiedades antiinflamatorias, utilizado principalmente en el tratamiento de condiciones respiratorias como el asma y la rinitis alérgica. Se caracteriza por su alta potencia y acción selectiva sobre los receptores de glucocorticoides, lo que ayuda a reducir la inflamación y la respuesta inmune en las vías respiratorias. La sustancia se administra típicamente por inhalación, aerosol nasal o formulaciones tópicas, permitiendo efectos localizados con una mínima absorción sistémica. Propionato de fluticasona es conocido por su favorable perfil farmacocinético, que incluye una vida media relativamente larga y un extenso metabolismo de primer paso, lo que contribuye a su eficacia y seguridad. El compuesto generalmente es bien tolerado, aunque los efectos secundarios potenciales pueden incluir irritación local, dolor de cabeza o, con el uso a largo plazo, efectos sistémicos como la supresión adrenal. Su estructura química incluye un esqueleto esteroide fluorinado, que mejora su potencia y estabilidad. En general, Propionato de fluticasona es un medicamento crítico en el manejo de condiciones inflamatorias crónicas, proporcionando un alivio significativo para los pacientes cuando se utiliza adecuadamente.
Fórmula:C25H31F3O5S
InChI:InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
Clave InChI:InChIKey=WMWTYOKRWGGJOA-CENSZEJFSA-N
SMILES:O(C(CC)=O)[C@@]1(C(SCF)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[H])[H]
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Fluticasone propionate for impurity C identification CRS
CAS:Fluticasone propionate for impurity C identification CRSFórmula:C25H31F3O5SForma y color:White. Powder.Peso molecular:500.5708Fluticasone propionate for system suitability CRS
CAS:Fluticasone propionate for system suitability CRSFluticasone propionate - micronised pharma grade
CAS:Glucocorticoid receptor agonist; anti-inflammatoryFórmula:C25H31F3O5SPureza:(Hplc) 96.0 To 102.0%Forma y color:White PowderPeso molecular:500.57 g/molFluticasone propionate
CAS:Fluticasone propionateFórmula:C25H31F3O5SPureza:99.7%Forma y color:White SolidPeso molecular:500.18443Fluticasone Propionate
CAS:Fórmula:C25H31F3O5SForma y color:White To Off-White SolidPeso molecular:500.57Fluticasone propionate
CAS:Fórmula:C25H31F3O5SPureza:≥ 98.0% (dried basis)Forma y color:White or almost white powderPeso molecular:500.57GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol
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Forma y color:MixtureFluticasone Propionate
CAS:Applications Fluticasone Propionate is a derivative of Flumethasone, a glucocorticoid. Fluticasone Propionate has antiallergic, anti-asthmatic, and anti-inflammatory properties (1,2,3). References (1) Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990) (2) Mitchison, H.C., et al.: Gut, 32, 260 (1991) (3) Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)Fórmula:C25H31F3O5SForma y color:WhitePeso molecular:500.57Fluticasone (propionate)
CAS:Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR agonist.Fórmula:C25H31F3O5SPureza:100% - 98.98%Forma y color:Crystalline SolidPeso molecular:500.57Ref: TM-T0188
5mg49,00€10mg79,00€25mg124,00€50mg187,00€100mg271,00€200mg339,00€500mg560,00€1mL*10mM (DMSO)84,00€Fluticasone propionate 100 µg/mL in Acetonitrile
CAS:Fórmula:C25H31F3O5SForma y color:Single SolutionPeso molecular:500.57Fluticasone propionate
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C25H31F3O5SForma y color:Powder, White to off-whitePeso molecular:500.57Fluticasone propionate - Bio-X ™
CAS:As a synthetic trifluorinated glucocorticoid receptor agonist, Fluticasone exhibits anti-inflammatory properties. When binding to and activating glucocorticoid receptors, Fluticasone initiates the activation of lipocortin which inhibits cytosolic phospholipase A2. Consequently, the cascade of inflammatory mediator synthesis reactions are inactivated and the production of inflammatory cells namely mast cells, dendritic cells, macrophages and eosinophils and the cytokines that they produce are greatly reduced.It is this anti-inflammatory role which has enabled Fluticasone to successfully treat conditions such as asthma, emphysema, allergic rhinitis and atopic dermatitis. It has also been seen to increase anti-inflammatory effects of annexoin-1 and mitogen-activated kinase phosphatase-1; reduce mucus gland secretions and increase the number of beta-2 receptors on smooth muscles of the airways. Fluticasone is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C25H31F3O5SPureza:Min. 95%Forma y color:White/Off-White SolidPeso molecular:500.57 g/molFluticasone Propionate
CAS:Halogenated derivatives of adrenal cortical hormonesFórmula:C25H31F3O5SForma y color:White PowderPeso molecular:500.18443Fluticasone Propionate-d3
CAS:Producto controladoApplications A labelled derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory. References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)Fórmula:C25H28D3F3O5SForma y color:NeatPeso molecular:503.59
