CAS 84625-61-6: Itraconazol
Descripción:
Itraconazol es un agente antifúngico triazólico que se utiliza principalmente para tratar diversas infecciones fúngicas, incluidas las causadas por dermatofitos, levaduras y ciertos mohos. Funciona inhibiendo la síntesis de ergosterol, un componente esencial de las membranas celulares fúngicas, interrumpiendo así su integridad y función. Itraconazol se caracteriza por su relativamente baja solubilidad en agua, pero es más soluble en disolventes orgánicos, lo que influye en su biodisponibilidad. El compuesto tiene una fórmula molecular de C35H38Cl2N8O4S y presenta una estructura compleja que incluye un anillo triazólico. Se administra típicamente por vía oral o intravenosa, con su farmacocinética influenciada por factores como la ingesta de alimentos y los niveles de pH. Itraconazol es conocido por su amplio espectro de actividad contra varios hongos, pero también puede interactuar con otros medicamentos debido a sus efectos sobre las enzimas hepáticas. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, elevaciones de las enzimas hepáticas y posibles efectos cardiovasculares, lo que requiere un monitoreo durante el tratamiento.
Fórmula:C35H38Cl2N8O4
InChI:InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2
Clave InChI:InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N
SMILES:C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7
Sinónimos:- 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
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ITRACONAZOLE CRS
CAS:ITRACONAZOLE CRSFórmula:C35H38Cl2N8O4Forma y color:White. Powder.Peso molecular:705.6334Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:99.0 - 101.0 % (dried basis)Forma y color:White or almost white powderPeso molecular:705.63Itraconazole, 99%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C35H38Cl2N8O4Pureza:99%Forma y color:White to almost white, PowderPeso molecular:705.64Itraconazole - Bio-X ™
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia. Itraconazole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C35H38Cl2N8O4Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:705.63 g/molItraconazole N-Oxide
CAS:Fórmula:C35H38Cl2N8O5Forma y color:White To Off-White SolidPeso molecular:721.64Itraconazole
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.Fórmula:C35H38Cl2N8O4Pureza:Min. 98.5 Area-%Forma y color:White PowderPeso molecular:705.63 g/molItraconazole
CAS:ItraconazoleFórmula:C35H38CI2N8O4Pureza:99.7%Forma y color:White To Off-WhitePeso molecular:900.11055Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:705.64
