CAS: 944342-90-9

ErbB receptor family inhibitor

JNJ 28871063 hydrochloride is a cationic small molecule that can target cancer cells by binding to overexpressed ICAM-1. It is an experimental drug candidate that has been shown to inhibit tumor growth and reduce the size of tumors in animal models. JNJ 28871063 hydrochloride is also able to selectively cross the blood brain barrier and bind to brain tumor cells, indicating that it may be useful for treating cancers in this area. The drug has been encapsulated in liposomes or hydrogels, which are designed to release the drug at a controlled rate and prevent it from being metabolized before it reaches its target.