CAS: 97148-38-4

Applications E-Ceftazidime is an impurity of Ceftazidime Pentahydrate (C244100); which is a third generation cephalosporin antibiotic. References Brodie, A., et al.: Antimicrob. Agents Chemother., 17, 876 (1980); Richards, D.M., et al.: Drugs, 29, 105 (1985); Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 19, 95 (1990)

E-Ceftazidime is a third-generation cephalosporin antibiotic, which is derived from the mold Acremonium. It functions by inhibiting bacterial cell wall synthesis, a crucial component for bacterial survival and replication. This inhibition occurs through the binding to specific penicillin-binding proteins (PBPs) within the bacterial cell wall, thus preventing cross-linking of the peptidoglycan chains, which results in the eventual lysis and death of the bacterial cell. E-Ceftazidime is primarily used to combat a range of Gram-negative bacterial infections, including those caused by Pseudomonas aeruginosa. It is frequently utilized in clinical settings for the treatment of severe and complicated infections such as those in the respiratory tract, urinary tract, skin, soft tissues, and in cases of bacteremia and sepsis. The antibiotic is especially significant in treating infections resistant to other antibiotics, particularly in immunocompromised patients. Understanding the pharmacokinetics and spectrum of activity of E-Ceftazidime is critical for its effective application in antimicrobial therapy.