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CAS 98796-51-1: Timidina, 5'-O-[bis(4-metoxifenil)fenilmetil]-, 3'-[2-cianoetil N,N-bis(1-metiletil)fosforamidita]
Descripción:
Timidina, 5'-O-[bis(4-metoxifenil)fenilmetil]-, 3'-[2-cianoetil N,N-bis(1-metiletil)fosforamidita], comúnmente conocido por su número CAS 98796-51-1, es un derivado nucleosídico sintético utilizado principalmente en el campo de la biología molecular y la bioquímica. Este compuesto presenta una base de timidina, que es un componente del ADN, modificada en las posiciones 5' y 3'. La posición 5' está sustituida por un grupo bis(4-metoxifenilo)fenilmetilo, que mejora su estabilidad y solubilidad, mientras que la posición 3' está modificada con un moiety de cianoetilo fosforamidito, que es crucial para su papel en la síntesis de oligonucleótidos. La presencia del grupo fosforamidito permite la incorporación de este compuesto en cadenas de ADN durante la síntesis en fase sólida, lo que lo hace valioso para la producción de oligonucleótidos personalizados para aplicaciones de investigación y terapéuticas. Sus características estructurales contribuyen a su reactividad y utilidad en varios procesos bioquímicos, particularmente en la síntesis de análogos de ADN y ARN.
Fórmula:C40H49N4O8P
InChI:InChI=1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-35-24-37(43-25-29(5)38(45)42-39(43)46)51-36(35)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,53?/m0/s1
Clave InChI:InChIKey=UNOTXUFIWPRZJX-CEXSRUIHSA-N
SMILES:C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@@H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5
Sinónimos:- 5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
- 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-cyanoethyl Phosphoramidite
- 5′-O-(4,4′-Dimethoxytrityl)thymidine 3′-(2-cyanoethyl-N,N-diisopropylphosphoramidite)
- 5′-O-(4,4′-Dimethoxytriyl)thymidine 3′-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
- 5′-O-DMT-thymidine 3′-CE phosphoramidite
- DMT-dT phosphoramidite
- DNA T Phosphoramidite
- DT-CE phosphoramidite
- Deoxythymidine phosphoramidite
- Thymidine phosphoramidite
- Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
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Encontrado 8 productos.
T β-Cyanoethyl Phosphoramidite (5'-O-Dimethoxytritylthymidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C40H49N4O8PForma y color:White PowderPeso molecular:744.32885'-O-DMT-thymidine 3'-CE phosphoramidite
CAS:5'-O-DMT-thymidine 3'-CE phosphoramidite is a building block for the introduction of thymidine units into oligonucleotides. 5'-O-DMT-thymidine 3'-CE phosphoramidite is utilised in a broad range of applications, including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.Fórmula:C40H49N4O8PPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:744.83 g/molDMT-dT Phosphoramidite
CAS:DMT-dT Phosphoramidite is typically used in the synthesis of DNA.Fórmula:C40H49N4O8PForma y color:SolidPeso molecular:744.81DMT-dT Phosphoramidite
CAS:Fórmula:C40H49N4O8PPureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:744.83Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]
CAS:Fórmula:C40H49N4O8PPureza:97%Forma y color:SolidPeso molecular:744.8128210000002
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