EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Productos de "EGFR"
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Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Fórmula:C18H24N2OSPureza:99.05%Forma y color:SolidPeso molecular:316.46Desmethyl Erlotinib hydrochloride
CAS:Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.Fórmula:C21H21N3O4·HClPureza:99.49%Forma y color:SolidPeso molecular:415.87Ref: TM-T6619
1mg59,00€2mg84,00€5mg115,00€10mg188,00€25mg335,00€50mg505,00€100mg720,00€1mL*10mM (DMSO)127,00€PROTAC EGFR degrader 8
CAS:PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells.Fórmula:C40H46ClN11O5Pureza:98%Forma y color:SolidPeso molecular:796.32lavendustin A
CAS:lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Fórmula:C21H19NO6Pureza:98%Forma y color:Off-White SolidPeso molecular:381.38EGFR ligand-11
CAS:EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.Fórmula:C25H29ClFN5O4Forma y color:SolidPeso molecular:517.98RG14620
CAS:RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C14H8Cl2N2Pureza:99.56% - 99.82%Forma y color:SolidPeso molecular:275.13Ref: TM-T3554
2mg35,00€5mg52,00€10mg77,00€25mg137,00€50mg259,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)58,00€BLU-945
CAS:BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.Fórmula:C28H37FN6O3SPureza:99.11% - 99.16%Forma y color:SolidPeso molecular:556.71,5-Dihydroxyxanthone
CAS:1,5-Dihydroxyxanthone inhibits EGFR-tyrosine kinase (IC50: 90.34 nM) and may block AChE/BChE.Fórmula:C13H8O4Pureza:98%Forma y color:SolidPeso molecular:228.203DA-0157
CAS:DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Fórmula:C31H43BrN7O2PForma y color:SolidPeso molecular:656.597EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Forma y color:Odour SolidEGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Pureza:98%Forma y color:Odour SolidIBI-334
IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.Forma y color:Odour LiquidBI-4020
CAS:BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Fórmula:C30H38N8O2Pureza:100.00% - 98.44%Forma y color:SolidPeso molecular:542.68Ref: TM-T10534
1mg170,00€5mg398,00€10mg568,00€25mg848,00€50mg1.130,00€100mg1.510,00€200mg2.062,00€1mL*10mM (DMSO)472,00€CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFórmula:C26H29N5O2Pureza:98.23%Forma y color:SolidPeso molecular:443.54Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Forma y color:Odour LiquidPD-149163 hydrochloride
PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.Fórmula:C42H72ClN9O6Forma y color:SolidPeso molecular:834.53Rilematovir
CAS:Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Fórmula:C21H20ClF3N4O3SPureza:99.82%Forma y color:SolidPeso molecular:500.92Mutated EGFR-IN-1
CAS:Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFórmula:C25H31N7OPureza:98.91%Forma y color:SolidPeso molecular:445.56Allitinib tosylate
CAS:Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Fórmula:C31H26ClFN4O5SPureza:98.46% - 98.68%Forma y color:SolidPeso molecular:621.08
