BTK
Los inhibidores de la tirosina quinasa de Bruton (BTK) son compuestos que específicamente se dirigen e inhiben la BTK, una enzima crucial involucrada en la señalización del receptor de células B y en la regulación de la angiogénesis. La BTK desempeña un papel significativo en la proliferación y supervivencia de las células cancerosas, particularmente en las malignidades hematológicas. Al inhibir la BTK, estos compuestos pueden interrumpir la angiogénesis y el crecimiento tumoral, lo que los convierte en valiosos en la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de BTK de alta calidad para apoyar su investigación en oncología, inmunología y angiogénesis.
Productos de "BTK"
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GDC-0834
CAS:GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse andFórmula:C33H36N6O3SForma y color:SolidPeso molecular:596.74BTK Protein, Human, Recombinant (His)
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Pureza:90%Forma y color:Lyophilized PowderPeso molecular:78.3 kDa (predicted)CHMFL-BTK-01
CAS:CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.Fórmula:C38H41N5O5Pureza:98%Forma y color:SolidPeso molecular:647.76PF-06250112
CAS:PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.Fórmula:C22H20F2N6O2Pureza:98%Forma y color:SolidPeso molecular:438.43Tirabrutinib hydrochloride
CAS:Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.Fórmula:C25H23ClN6O3Pureza:99.04% - 99.27%Forma y color:SolidPeso molecular:490.94JNJ-64264681
CAS:JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Fórmula:C27H30N6O3SPureza:98%Forma y color:SolidPeso molecular:518.63(R)-Zanubrutinib
CAS:(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).Fórmula:C27H29N5O3Pureza:98.04%Forma y color:SolidPeso molecular:471.55Ref: TM-T13447
1mg39,00€5mg85,00€10mg140,00€25mg226,00€50mg340,00€100mg467,00€200mg648,00€1mL*10mM (DMSO)89,00€G-744
CAS:G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM).Fórmula:C29H29N5O3SPureza:98%Forma y color:SolidPeso molecular:527.64Spebrutinib besylate
CAS:Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).Fórmula:C28H28FN5O6SPureza:98%Forma y color:SolidPeso molecular:581.62Ibrutinib
CAS:Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.Fórmula:C25H24N6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:440.5BTK inhibitor 1
CAS:BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.Fórmula:C24H23FN8O2Pureza:99.06% - 99.79%Forma y color:SolidPeso molecular:474.49WS-11
CAS:WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.Fórmula:C26H22FN9O2Forma y color:SolidPeso molecular:511.51TL-895
CAS:TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).Fórmula:C25H26FN5O2Pureza:99.59%Forma y color:SolidPeso molecular:447.5Ref: TM-T9705
2mg42,00€5mg64,00€10mg93,00€25mg180,00€50mg281,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)64,00€Branebrutinib
CAS:Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.Fórmula:C20H23FN4O2Pureza:95.86% - 99.39%Forma y color:SolidPeso molecular:370.42Ref: TM-T5407
1mg52,00€5mg114,00€10mg177,00€25mg354,00€50mg553,00€100mg793,00€200mg1.093,00€1mL*10mM (DMSO)125,00€Tyrosinase-IN-16
CAS:Tyrosinase-IN-16 inhibited tyrosinase.Fórmula:C8H6BrN3SPureza:100%Forma y color:SolidPeso molecular:256.12BTK-IN-38
CAS:BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.Fórmula:C27H26F2N4O2Forma y color:SolidPeso molecular:476.52Orelabrutinib
CAS:Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).Fórmula:C26H25N3O3Pureza:97.77% - 99.44%Forma y color:SolidPeso molecular:427.49Ref: TM-T12317
1mg90,00€5mg187,00€10mg315,00€25mg520,00€50mg720,00€100mg947,00€500mg1.890,00€1mL*10mM (DMSO)216,00€Spebrutinib
CAS:Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplasticFórmula:C22H22FN5O3Pureza:100% - 97.02%Forma y color:SolidPeso molecular:423.44Pirtobrutinib
CAS:Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.Fórmula:C22H21F4N5O3Pureza:99.76% - 99.94%Forma y color:SolidPeso molecular:479.43Ref: TM-T36287
1mg37,00€5mg79,00€10mg126,00€25mg283,00€50mg434,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)84,00€RN486
CAS:RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).Fórmula:C35H35FN6O3Pureza:99.38%Forma y color:SolidPeso molecular:606.69
