BCL
Los inhibidores de BCL son compuestos que se dirigen a la familia de proteínas BCL-2, que juegan un papel clave en la regulación de la apoptosis. La familia BCL-2 incluye miembros proapoptóticos y antiapoptóticos que controlan la vía mitocondrial de la apoptosis. Inhibir las proteínas BCL-2 antiapoptóticas puede promover la muerte celular en células cancerosas, lo que convierte a los inhibidores de BCL en herramientas cruciales en la investigación de terapias contra el cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de BCL de alta calidad para apoyar su investigación en cáncer, apoptosis y biología celular.
Productos de "BCL"
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Cimidahurinine
CAS:Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects againstFórmula:C14H20O8Pureza:98%Forma y color:SolidPeso molecular:316.3Mcl1-IN-12
CAS:Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Fórmula:C45H46N4O6S2Pureza:98%Forma y color:SolidPeso molecular:803BCL6-IN-7
CAS:BCL6-IN-7 (BCL6 inhibitor-7) is a BCL6 corepressor-interaction inhibitor with potential antitumor activity, used in lymphoma research.Fórmula:C18H15ClN6OPureza:99.03%Forma y color:SolidPeso molecular:366.82',3'-Dehydrosalannol
CAS:2',3'-Dehydrosalannol deters Spodptera litura and inhibits TNBC cell growth by blocking cathepsin signals.Fórmula:C32H42O8Pureza:98%Forma y color:SolidPeso molecular:554.68Mcl1-IN-9
CAS:Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.Fórmula:C37H39ClN4O4Pureza:98%Forma y color:SolidPeso molecular:639.18MCL-1/BCL-2-IN-1
CAS:MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].Fórmula:C31H27BrN2O3SPureza:98%Forma y color:SolidPeso molecular:587.53Myricanol
CAS:Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.Fórmula:C21H26O5Pureza:98%Forma y color:SolidPeso molecular:358.434Bax activator-1
CAS:Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].Fórmula:C29H36N4O3Forma y color:SolidPeso molecular:488.62Scutebarbatine A
CAS:Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions ofFórmula:C32H34N2O7Pureza:98%Forma y color:SolidPeso molecular:558.62Safflor Yellow A
CAS:Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.Fórmula:C27H30O15Pureza:98%Forma y color:SolidPeso molecular:594.52Mcl-1 inhibitor 3
CAS:Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activateFórmula:C40H52ClF2N5O7SPureza:98%Forma y color:SolidPeso molecular:820.39BM 957
CAS:BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).Fórmula:C52H56ClF3N6O7S3Pureza:98%Forma y color:SolidPeso molecular:1065.68
