Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Fórmula:C21H22N4OForma y color:SolidPeso molecular:346.43Gallium maltolate
CAS:Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Fórmula:C18H15GaO9Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:445.03Pyridostatin TFA
CAS:Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Forma y color:SolidPeso molecular:938.71TMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Fórmula:C17H20BrFN6O3SForma y color:SolidPeso molecular:487.347Stigmatellin
CAS:Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.Fórmula:C30H42O7Forma y color:SolidPeso molecular:514.65MGB-BP-3
CAS:MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.Fórmula:C36H37N7O4Pureza:97.06% - 98.92%Forma y color:SolidPeso molecular:631.72STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:95% - 95%Forma y color:Odour Liquid2',3'-Dideoxyuridine
CAS:2',3'-Dideoxyuridine is a purine nucleoside analog with potential antitumor activity.Fórmula:C9H12N2O4Pureza:99.76%Forma y color:SolidPeso molecular:212.2WRN inhibitor 11
CAS:WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Fórmula:C34H35ClF3N9O5Forma y color:SolidPeso molecular:742.15C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Forma y color:SolidPeso molecular:1562.85EMD534085
CAS:EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Fórmula:C25H31F3N4O2Pureza:98%Forma y color:SolidPeso molecular:476.535-Methylcytosine
CAS:5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA.Fórmula:C5H7N3OPureza:99.17%Forma y color:SolidPeso molecular:125.13SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Fórmula:C20H26ClN7Pureza:99.18%Forma y color:SolidPeso molecular:399.92Ref: TM-T8801
1mg92,00€5mg188,00€10mg306,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€3-AP
CAS:3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Fórmula:C7H9N5SPureza:97.33% - 99.75%Forma y color:SolidPeso molecular:195.24Ref: TM-T1982
2mg39,00€5mg57,00€10mg69,00€25mg150,00€50mg264,00€100mg400,00€500mg909,00€1mL*10mM (DMSO)57,00€Human PD-L1 inhibitor V
CAS:Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFórmula:C65H104N20O18SPureza:98%Forma y color:SolidPeso molecular:1485.71T521
CAS:T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Fórmula:C17H14FNO5S2Pureza:99.65%Forma y color:SolidPeso molecular:395.43AZ5576
CAS:AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].Fórmula:C21H24FN3O3Pureza:99.88%Forma y color:SoildPeso molecular:385.43Ref: TM-T60152
1mg35,00€5mg80,00€10mg113,00€25mg221,00€50mg331,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)87,00€PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Fórmula:C39H48Cl2N10O5Forma y color:SolidPeso molecular:807.768SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.95%Forma y color:SolidPeso molecular:376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Fórmula:C28H27N5OPureza:97.91%Forma y color:SolidPeso molecular:449.55DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Fórmula:C16H17NO4Pureza:98%Forma y color:SolidPeso molecular:287.31Aminopurvalanol A
CAS:Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Fórmula:C19H26ClN7OPureza:99.64%Forma y color:SolidPeso molecular:403.91Ref: TM-T22260
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)65,00€Sintilimab
CAS:Sintilimab (IBI308), an IgG4 monoclonal antibody, blocks PD-1, enhancing T-cell anti-tumor response; treats Hodgkin's, lung, and esophageal cancers.Pureza:> 95%Forma y color:LiquidPeso molecular:144.04 kDaAtuveciclib S-Enantiomer
CAS:Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Fórmula:C18H18FN5O2SPureza:98%Forma y color:SolidPeso molecular:387.43PD-1-IN-22
CAS:PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Fórmula:C25H25N5O4Pureza:98.64%Forma y color:SolidPeso molecular:459.5Ref: TM-T12379
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)299,00€CFI-402257
CAS:CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Forma y color:SolidPeso molecular:498.58CDK9-Cyclin T1 PPI-IN-1
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBCPureza:98%Forma y color:Odour SolidDamnacanthal
CAS:Damnacanthal is a natural anthraquinone with potential anticancer property, inhibiting a variety of protein kinases such as LIMK1, LIMK2 and Lck.Fórmula:C16H10O5Pureza:98%Forma y color:SolidPeso molecular:282.25RNA polymerase II-IN-1
CAS:RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Fórmula:C38H53N11O12SPureza:98%Forma y color:SolidPeso molecular:887.96SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Fórmula:C19H19ClN6OPureza:97.78%Forma y color:SolidPeso molecular:382.85CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Fórmula:C22H29ClN8Pureza:98%Forma y color:SolidPeso molecular:440.97Aurora A inhibitor 3
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-Pureza:98%Forma y color:Odour SolidProguanil
CAS:Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .Fórmula:C11H16ClN5Pureza:99.6%Forma y color:SolidPeso molecular:253.73KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.89%Forma y color:SolidPeso molecular:332.45-Aza-7-deazaguanine
CAS:5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.Fórmula:C5H5N5OPureza:98.87%Forma y color:SolidPeso molecular:151.138-Azaguanosine
CAS:8-Azaguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity and is used in the study of a variety of tumor diseases.Fórmula:C9H12N6O5Pureza:99.44%Forma y color:SolidPeso molecular:284.23BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Fórmula:C25H26N6OPureza:98.28%Forma y color:SolidPeso molecular:426.51(S)-Enitociclib
CAS:(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.Fórmula:C19H18F2N4O2SPureza:98.04%Forma y color:SolidPeso molecular:404.43Nicotinamide N-oxide
CAS:Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Fórmula:C6H6N2O2Pureza:99.61% - 99.9%Forma y color:SolidPeso molecular:138.12AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:100%Forma y color:SolidPeso molecular:405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€CDK8/19-IN-51
CAS:CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Fórmula:C23H22N6O2Pureza:100% - 98.65%Forma y color:SoildPeso molecular:414.46KOdiA-PC
CAS:KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.Fórmula:C32H58NO11PForma y color:SolidPeso molecular:663.78Envafolimab
CAS:Envafolimab (ASC 22) is a humanized antibody targeting PD-L1, with anticancer activity, blocking the PD-L1 and PD-1 interaction.Pureza:95%Forma y color:LiquidLY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Fórmula:C19H23N7O2Pureza:99.77%Forma y color:SolidPeso molecular:381.43Ref: TM-T9252
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)316,00€WAY-647802
CAS:WAY-647802 is a CDK inhibitor.Fórmula:C11H14N4O3Pureza:98.38%Forma y color:SolidPeso molecular:250.25Madrasin
CAS:Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.Fórmula:C16H17N5O2Pureza:99.44% - 99.61%Forma y color:SolidPeso molecular:311.34PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Forma y color:Odour SolidCCT 137690
CAS:CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Fórmula:C26H31BrN8OPureza:98.51% - 99.82%Forma y color:SolidPeso molecular:551.485'-O-DMT-N4-Bz-5-Me-dC
CAS:5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) is a modified nucleoside used in the synthesis of nucleoside phosphoramidites.Fórmula:C38H37N3O7Pureza:98.88%Forma y color:SolidPeso molecular:647.72Efalizumab
CAS:Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.Pureza:SDS-PAGE:95% SEC-HPLC:98.77%Forma y color:LiquidPeso molecular:146.14 kDaSR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Fórmula:C26H32O2Pureza:98%Forma y color:SolidPeso molecular:376.53Ref: TM-T23384
1mg137,00€5mg492,00€10mg797,00€25mg1.385,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)550,00€Nedaplatin
CAS:Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Fórmula:C2H8N2O3PtPureza:100% - 98.69%Forma y color:Straw Yellow PowderPeso molecular:303.17A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Fórmula:C15H12N2OS2Pureza:98.07% - 98.52%Forma y color:SolidPeso molecular:300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€N-6-Furfurylguanosine
CAS:N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.Fórmula:C15H18N6O5Pureza:99.58%Forma y color:SolidPeso molecular:362.34Ancitabine hydrochloride
CAS:Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Fórmula:C9H12ClN3O4Pureza:99.02% - 99.37%Forma y color:White SolidPeso molecular:261.66Uridine-5-acetic acid
CAS:Uridine-5-acetic acid (5-Carboxymethyluridine) is a nucleoside formed during RNA transfer processes in yeast and wheat embryos.Fórmula:C11H14N2O8Pureza:99.59%Forma y color:SolidPeso molecular:302.24PolQi2
CAS:PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.Fórmula:C21H16ClN5O3SPureza:99.19%Forma y color:SolidPeso molecular:453.9Ref: TM-T84770
1mg92,00€5mg188,00€10mg313,00€25mg603,00€50mg840,00€100mg1.169,00€200mg1.586,00€1mL*10mM (DMSO)216,00€CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Fórmula:C17H21BrN4OPureza:98%Forma y color:SolidPeso molecular:377.28Saccharin 1-methylimidazole
CAS:Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Fórmula:C7H5NO3S·C4H6N2Pureza:98.21%Forma y color:SolidPeso molecular:265.29THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:95.09% - 99.27%Forma y color:SolidPeso molecular:566.05Antiviral agent 36
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100Fórmula:C30H32N4O3Pureza:98%Forma y color:SolidPeso molecular:496.6m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Fórmula:C29H23IN2SePureza:98%Forma y color:SolidPeso molecular:605.37CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Fórmula:C23H18N6O2SPureza:97.24% - 99.10%Forma y color:SolidPeso molecular:442.49Ref: TM-T14916
1mg87,00€5mg202,00€10mg321,00€25mg550,00€50mg753,00€100mg1.074,00€1mL*10mM (DMSO)240,00€Bersiporocin
CAS:Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.Fórmula:C15H19Cl2N3OPureza:100% - 98.88%Forma y color:SolidPeso molecular:328.24ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44Ref: TM-T16391
1mg50,00€5mg74,00€10mg105,00€25mg182,00€50mg283,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)64,00€ICAM-1-IN-1
CAS:ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Fórmula:C15H11BrN2O2SPureza:99.34%Forma y color:SolidPeso molecular:363.23Ref: TM-T13147
1mg185,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Fórmula:C16H21N7O2Forma y color:SolidPeso molecular:343.384MYCi361
CAS:MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Fórmula:C26H16ClF9N2O2Pureza:99.52%Forma y color:SolidPeso molecular:594.86Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Fórmula:C16H18N2O2SPureza:98.07%Forma y color:SolidPeso molecular:302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.90%Forma y color:SolidPeso molecular:552.63Ref: TM-T15732
2mg35,00€5mg51,00€10mg73,00€25mg97,00€50mg115,00€100mg168,00€200mg271,00€500mg484,00€1mL*10mM (DMSO)64,00€HAMNO
CAS:HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Fórmula:C17H13NO2Pureza:99.96%Forma y color:SolidPeso molecular:263.29BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Fórmula:C14H16N2OSPureza:99.68%Forma y color:SolidPeso molecular:260.35Ref: TM-T36964
5mg50,00€10mg85,00€25mg169,00€50mg279,00€100mg487,00€500mg1.035,00€1mL*10mM (DMSO)52,00€WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Fórmula:C35H40F4N10O5Forma y color:SolidPeso molecular:756.75Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Fórmula:C46H52Na2O16Pureza:98%Forma y color:SolidPeso molecular:906.888-Bromoadenosine
CAS:8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Fórmula:C10H12BrN5O4Pureza:99.11%Forma y color:SolidPeso molecular:346.14SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Fórmula:C15H18Br2N4Pureza:100% - 99.7%Forma y color:SolidPeso molecular:414.14NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Fórmula:C18H14N2O3Pureza:99.27%Forma y color:SolidPeso molecular:306.32Ref: TM-T8800
5mg70,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)77,00€CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Fórmula:C11H8F3N3OPureza:97.09%Forma y color:SolidPeso molecular:255.2Ref: TM-T10740
1mg87,00€5mg216,00€10mg311,00€25mg525,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)240,00€Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Fórmula:C51H64N4O13Pureza:98%Forma y color:SolidPeso molecular:941.07GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Fórmula:C21H24FN7Forma y color:SolidPeso molecular:393.46Rifapentine
CAS:Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.Fórmula:C47H64N4O12Pureza:95.74% - ≥98%Forma y color:SolidPeso molecular:877.032-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Fórmula:C22H17N3O2Forma y color:SolidPeso molecular:355.39Ganciclovir
CAS:Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.Fórmula:C9H13N5O4Pureza:99.4% - 99.55%Forma y color:White PowderPeso molecular:255.23Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Fórmula:C32H34F3N9O5Pureza:99.02%Forma y color:SolidPeso molecular:681.67Digeranyl bisphosphonate
CAS:Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFórmula:C21H34Na4O6P2Pureza:98.5%Forma y color:SolidPeso molecular:536.4Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Fórmula:C9H4F3N3O4SPureza:99.5%Forma y color:SolidPeso molecular:307.21Ref: TM-T22700
1mg92,00€5mg216,00€10mg338,00€25mg540,00€50mg747,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)240,00€Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Fórmula:C19H26N6OPureza:97.15% - 99.88%Forma y color:White To Off-White SolidPeso molecular:354.45NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:100% - 99.36%Forma y color:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg48,00€5mg97,00€10mg145,00€25mg269,00€50mg395,00€100mg563,00€200mg743,00€1mL*10mM (DMSO)99,00€Deoxyguanosine triphosphate trisodium salt
CAS:Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can beFórmula:C10H13N5Na3O13P3Pureza:98.73%Forma y color:SolidPeso molecular:573.13WRN inhibitor 18
CAS:WRN inhibitor 18 (compound 306) is an orally active inhibitor of WRN with demonstrated anticancer activity in vivo.Fórmula:C35H35F6N5O5SForma y color:SolidPeso molecular:751.747-Methylxanthine
CAS:7-Methylxanthine, a xanthine methyl derivative, prevents FDM by altering the sclera in rabbits. It's a purine in kidney stones.Fórmula:C6H6N4O2Pureza:97.66% - 98.58%Forma y color:SolidPeso molecular:166.14sAJM589
CAS:sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Fórmula:C16H10N2OPureza:98%Forma y color:SolidPeso molecular:246.266-Mercaptopurine hydrate
CAS:6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Fórmula:C5H6N4OSPureza:97.54% - 99.14%Forma y color:Light Yellow Crystalline PowderPeso molecular:170.19Nusinersen
CAS:Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Forma y color:SolidMirvetuximab soravtansine
CAS:Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancerPureza:95%Forma y color:LiquidButyrolactone I
CAS:Butyrolactone I (Olomoucin) inhibits CDKs, blocks cdc2 kinases, and shows antitumor activity in lung and prostate cancers.Fórmula:C24H24O7Pureza:98%Forma y color:SolidPeso molecular:424.44CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Fórmula:C27H28F4N8Pureza:98%Forma y color:SolidPeso molecular:540.56CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Fórmula:C27H31N3O4Pureza:98%Forma y color:SolidPeso molecular:461.55PD-1/PD-L1-IN-34
CAS:PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Fórmula:C35H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:565.1CDK9-IN-28
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis.Fórmula:C32H40N4O6S2Pureza:98%Forma y color:SolidPeso molecular:640.81
