Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Forma y color:SolidPeso molecular:337.81T025
CAS:T025 inhibits CLK1-4 (Kds: 0.074-6.5 nM), shows anti-cancer effects (IC50: 30-300 nM), useful for MYC-related disease research.Fórmula:C21H18N8Pureza:98.08%Forma y color:SolidPeso molecular:382.42Ref: TM-T13058
1mg143,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Fórmula:C29H26FN5O4SPureza:97.45% - 98.44%Forma y color:SolidPeso molecular:559.61Ref: TM-T8487
1mg90,00€5mg183,00€10mg275,00€25mg449,00€50mg615,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)245,00€CDK2 degrader 4
CAS:CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Fórmula:C23H26ClN3O5Forma y color:SolidPeso molecular:459.923Adebrelimab
CAS:Adebrelimab (SHR-1316) is a humanized monoclonal antibody targeting PD-L1 with antitumor activity for the study of solid tumors.Pureza:95% - 95%Forma y color:LiquidCHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:98.02%Forma y color:SoildPeso molecular:480.75BT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Pureza:98%Forma y color:Odour Solid2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine
CAS:2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.Fórmula:C10H15N3O5Pureza:96.76%Forma y color:SolidPeso molecular:257.24AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.88%Forma y color:SolidPeso molecular:456.37Cdk1/2 Inhibitor III
CAS:Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Fórmula:C15H13F2N7O2S2Pureza:100%Forma y color:SolidPeso molecular:425.44Ref: TM-T14914
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Forma y color:SolidPeso molecular:393.89Ref: TM-T23917
1mg65,00€5mg140,00€10mg216,00€25mg439,00€50mg707,00€100mg1.130,00€1mL*10mM (DMSO)156,00€IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Fórmula:C24H24N2O6Pureza:98%Forma y color:SolidPeso molecular:436.46Isoguanine
CAS:Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.Fórmula:C5H5N5OPureza:99.90%Forma y color:SolidPeso molecular:151.13Vidarabine
CAS:Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.Fórmula:C10H13N5O4Pureza:100%Forma y color:White To Off-White Crystalline PowderPeso molecular:267.24Rac1 Inhibitor F56, control peptide acetate
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe.Fórmula:C74H120N18O25SPureza:98%Forma y color:SolidPeso molecular:1692.94Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Fórmula:C24H28Cl2N2O3S2Forma y color:SolidPeso molecular:527.53rel-(2S,3R)-Voruciclib hydrochloride
CAS:Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.Fórmula:C22H20Cl2F3NO5Pureza:98%Forma y color:SolidPeso molecular:506.3CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Forma y color:SolidPeso molecular:400.47Ref: TM-T3195
1mg44,00€2mg55,00€5mg88,00€10mg118,00€25mg208,00€50mg380,00€100mg565,00€1mL*10mM (DMSO)88,00€Prolgolimab
CAS:Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.Pureza:>95%Forma y color:Liquid6-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Fórmula:C11H15N5O5Pureza:97.50%Forma y color:SolidPeso molecular:297.27Lysidine
CAS:Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.Fórmula:C4H8N2Pureza:98%Forma y color:Light Yellow To Off-White CrystallinePeso molecular:84.12Trifluridine
CAS:Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties, disrupting DNA and protein synthesis, leading to apoptosis.Fórmula:C10H11F3N2O5Pureza:99.39% - 99.82%Forma y color:White Crystalline PowderPeso molecular:296.2Haspin-IN-3
CAS:Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.Fórmula:C16H10N2O3Pureza:98.78%Forma y color:SolidPeso molecular:278.261-Methylcytosine
CAS:1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired withFórmula:C5H7N3OPureza:100%Forma y color:SolidPeso molecular:125.13MM41
CAS:MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.Fórmula:C44H66N10O6Pureza:97.13%Forma y color:SolidPeso molecular:831.06Ref: TM-T60028
1mg52,00€5mg116,00€10mg178,00€25mg293,00€50mg393,00€100mg520,00€200mg712,00€1mL*10mM (DMSO)160,00€Kira8
CAS:Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).Fórmula:C31H29ClN6O3SPureza:98.07%Forma y color:SolidPeso molecular:601.12Ref: TM-T11762L
1mg87,00€5mg202,00€10mg305,00€25mg567,00€50mg810,00€100mg1.111,00€1mL*10mM (DMSO)269,00€SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Fórmula:C20H27ClN8OSPureza:98.29%Forma y color:SolidPeso molecular:463Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Fórmula:C7H7NO4Pureza:96.85%Forma y color:SolidPeso molecular:169.13DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.Fórmula:C41H49N4O9PPureza:98.28%Forma y color:SolidPeso molecular:772.82HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Fórmula:C22H20N2O5SPureza:100% - 98.63%Forma y color:SolidPeso molecular:424.47Ref: TM-T2438
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)92,00€Durvalumab
CAS:Durvalumab is a humanized antibody for cancer, inhibiting PD-L1/PD-1 and CD80 interactions at very low concentrations.Pureza:SDS-PAGE:97.2%;SEC-HPLC:95.3%Forma y color:LiquidPeso molecular:146.03 kDaILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Fórmula:C30H30F3N5OPureza:99.30%Forma y color:SolidPeso molecular:533.59Ref: TM-T5488
1mg48,00€5mg97,00€10mg128,00€25mg162,00€50mg192,00€100mg281,00€200mg408,00€1mL*10mM (DMSO)137,00€Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].Fórmula:C28H32F2N8Pureza:98%Forma y color:SolidPeso molecular:518.6MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46Ref: TM-T22106
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Forma y color:SolidPeso molecular:525.6BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Forma y color:SolidPeso molecular:464.56Ref: TM-T6785
1mg49,00€5mg97,00€10mg153,00€25mg296,00€50mg445,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)97,00€CASIN
CAS:CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Fórmula:C20H22N2OPureza:100% - 99.86%Forma y color:SolidPeso molecular:306.4Ref: TM-T3971
1mg38,00€2mg49,00€5mg74,00€10mg120,00€25mg188,00€50mg283,00€100mg435,00€500mg938,00€1mL*10mM (DMSO)74,00€Kaempferitrin
CAS:Kaempferitrin has antidepressant effects via 5-HT1A, targets HeLa cells, promotes glucose control, and boosts immune function, including NK cells.Fórmula:C27H30O14Pureza:98% - 99.59%Forma y color:SolidPeso molecular:578.52Ref: TM-T3386
1mg50,00€5mg123,00€10mg207,00€25mg349,00€50mg515,00€100mg735,00€500mg1.483,00€1mL*10mM (DMSO)156,00€Nolatrexed
CAS:Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.Fórmula:C14H12N4OSPureza:97.91%Forma y color:SolidPeso molecular:284.34Ref: TM-T4228
1mg42,00€2mg50,00€5mg90,00€10mg148,00€25mg240,00€50mg430,00€100mg633,00€1mL*10mM (DMSO)96,00€BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Fórmula:C21H20N4O2Pureza:98.87% - 99.53%Forma y color:SolidPeso molecular:360.41Reozalimab
CAS:Rezilimab is a bispecific antibody that targets PD-1/PD-L1 and mediates antibody-dependent cell cytotoxicity (ADCC) in cancer research [1] [2].Pureza:98%Forma y color:LiquidN1-Methylpseudouridine-5'-triphosphate
CAS:N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.Fórmula:C10H17N2O15P3Pureza:98.18%Forma y color:SolidPeso molecular:498.17BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:95.83% - 99.88%Forma y color:SolidPeso molecular:431.29Ref: TM-T4598
1mg43,00€2mg55,00€5mg84,00€10mg123,00€25mg198,00€50mg298,00€100mg444,00€1mL*10mM (DMSO)92,00€Fialuridine
CAS:Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.Fórmula:C9H10FIN2O5Pureza:99.71% - 99.90%Forma y color:Less Crystals Colourless CrystalsPeso molecular:372.09Ref: TM-T7655
1mg35,00€5mg74,00€10mg116,00€25mg235,00€50mg373,00€100mg562,00€500mg1.216,00€1mL*10mM (DMSO)82,00€CDK4/6-IN-24
CAS:CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.Fórmula:C32H41N7O3Forma y color:SolidPeso molecular:571.713Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.40%Forma y color:SolidPeso molecular:569.44Ref: TM-T30751
10g9.508,00€1mg74,00€5mg160,00€10mg264,00€25mg528,00€50mg785,00€100mg1.130,00€200mg1.549,00€1mL*10mM (DMSO)170,00€1ACTA
CAS:1ACTA (IRE1αS-nitrosylation inhibitor) is a compound that helps maintain the endoplasmic reticulum stress response under conditions of nitrosative stress.Fórmula:C14H16N2O2Forma y color:SolidPeso molecular:244.29NRTT-IN-1
CAS:NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.Fórmula:C28H24FN5O5Forma y color:SolidPeso molecular:529.519PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Pureza:95%Forma y color:LiquidPOL1-IN-1
CAS:POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。Fórmula:C21H20N6Pureza:98%Forma y color:SolidPeso molecular:356.42Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activationFórmula:C76H121N19O25SPureza:98.96%Forma y color:SolidPeso molecular:1732.95CAF-382
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinityFórmula:C16H22N4O2S2Pureza:98%Forma y color:SolidPeso molecular:366.5PD-L1-IN-3
CAS:PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Fórmula:C19H15ClFN2OSPureza:99.47%Forma y color:SoildPeso molecular:373.85DHX9-IN-2
CAS:DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.Fórmula:C18H16ClN3O3S2Pureza:98.00%Forma y color:SolidPeso molecular:421.92β-glycosidase-IN-1
CAS:β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.Fórmula:C13H23NO5Pureza:98%Forma y color:SolidPeso molecular:273.33Orotic acid
CAS:Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.Fórmula:C5H4N2O4Pureza:99.42%Forma y color:Crystals Physical Description White Crystals Or Crystalline Powder (Ntp 1992)Peso molecular:156.1IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Fórmula:C16H12BrClFNO4Pureza:99.56%Forma y color:SolidPeso molecular:416.63BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Fórmula:C12H9BrN2OSPureza:99.91% - ≥95%Forma y color:SolidPeso molecular:309.18Ref: TM-T9033
5mg48,00€10mg63,00€25mg93,00€50mg136,00€100mg198,00€200mg309,00€500mg563,00€1mL*10mM (DMSO)50,00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.45% - 98.43%Forma y color:SolidPeso molecular:475.42PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Fórmula:C24H37N3O4Pureza:99.25%Forma y color:SoildPeso molecular:431.57Ref: TM-T60101
1mg52,00€5mg111,00€10mg180,00€25mg305,00€50mg439,00€100mg612,00€1mL*10mM (DMSO)124,00€RdRP-IN-6
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM.Fórmula:C41H67N8O7PSi2Pureza:98%Forma y color:SolidPeso molecular:871.16Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.16%Forma y color:SolidPeso molecular:499.5Ref: TM-TQ0291
1mg47,00€5mg87,00€10mg140,00€25mg283,00€50mg464,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)97,00€Pacmilimab
CAS:Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Pureza:95% - 95%Forma y color:LiquidNUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C25H30N6OForma y color:SolidPeso molecular:430.545MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Forma y color:SolidPeso molecular:476.86Ref: TM-T6315
1mg52,00€2mg71,00€5mg88,00€10mg127,00€25mg233,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)93,00€2,5-Di-tert-butyl-1,4-benzoquinone
CAS:2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.Fórmula:C14H20O2Forma y color:SolidPeso molecular:220.31AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM),具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶,在细胞周期中对 DNA 复制的启动至关重要。Fórmula:C21H22F3N5O4Pureza:100%Forma y color:SolidPeso molecular:465.43DI-87
CAS:DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor. DI-87 binds to dCK reduces the production of dNTP inhibits tumor growth.Fórmula:C23H30N6O3S2Pureza:99.76%Forma y color:SolidPeso molecular:502.65Levoleucovorin Calcium
CAS:Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.Fórmula:C20H21N7O7·CaPureza:98.46% - ≥98%Forma y color:White Crystalline PowderPeso molecular:511.5PROTAC CDK9 degrader-6
CAS:PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Fórmula:C42H49Cl2N9O8Pureza:98%Forma y color:SolidPeso molecular:878.8THZ1-R
CAS:THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).Fórmula:C31H30ClN7O2Pureza:98%Forma y color:SolidPeso molecular:568.07CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Fórmula:C24H16FN5OForma y color:SolidPeso molecular:409.42Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Forma y color:LiquidCDK-TCIP2
DK-TCIP2 is an anticancer agent formed by linking the CDK9 inhibitor SNS-032 and the BCL6 inhibitor BI-3812. This compound exhibits anticancer activity both in vivo and in vitro, making it suitable for research in lymphoma.Fórmula:C52H67ClN12O8S2Forma y color:SolidPeso molecular:1087.75SIBA
CAS:SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.Fórmula:C14H21N5O3SPureza:99.48%Forma y color:SolidPeso molecular:339.41Ref: TM-T12908
1mg52,00€5mg94,00€10mg117,00€25mg220,00€50mg329,00€100mg469,00€200mg652,00€1mL*10mM (DMSO)104,00€(R)-Simurosertib
CAS:(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Fórmula:C17H19N5OSPureza:99.64%Forma y color:SolidPeso molecular:341.43JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.66%Forma y color:SolidPeso molecular:394.36Ref: TM-T6126
1mg50,00€2mg66,00€5mg105,00€10mg180,00€25mg284,00€50mg520,00€100mg728,00€500mg1.473,00€1mL*10mM (DMSO)88,00€2'-Deoxy-2'-fluorocytidine
CAS:2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.Fórmula:C9H12FN3O4Pureza:99.03%Forma y color:White Or Almost White Crystalline PowderPeso molecular:245.21Bleomycin hydrochloride
CAS:Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.Fórmula:C55H84ClN17O21S3Pureza:98%Forma y color:SoildPeso molecular:1451.01(Average)Mithramycin A
CAS:Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of variousFórmula:C52H76O24Pureza:99.28%Forma y color:Yellow PowderPeso molecular:1085.15CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:97.06% - 99.69%Forma y color:SolidPeso molecular:379.34Ref: TM-T7080
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg225,00€50mg369,00€100mg552,00€1mL*10mM (DMSO)92,00€DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFórmula:C14H9Cl2N3O4SPureza:98%Forma y color:SolidPeso molecular:386.21IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Fórmula:C13H11Cl2NO4Pureza:99.89%Forma y color:SolidPeso molecular:316.14Ref: TM-T40419
1mg103,00€5mg246,00€10mg395,00€25mg785,00€50mg1.198,00€100mg1.853,00€200mg2.498,00€1mL*10mM (DMSO)271,00€STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Fórmula:C15H11NO3S2Pureza:97.53% - 98.85%Forma y color:SolidPeso molecular:317.38Ref: TM-T6681
5mg51,00€10mg80,00€25mg120,00€50mg205,00€100mg368,00€200mg555,00€500mg810,00€1mL*10mM (DMSO)58,00€ARB-272572
CAS:ARB-272572 is a PD-L1 signaling inhibitor that produces immunostimulatory activity in human primary cells.Fórmula:C32H36N6O4Pureza:97.36% - 98.07%Forma y color:SolidPeso molecular:568.675-Bromo-2',3',5'-tri-O-acetyluridine
CAS:5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that can be used to explore explore improve Parkinson's disease.Fórmula:C15H17BrN2O9Pureza:99%Forma y color:SolidPeso molecular:449.21(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Fórmula:C31H30Cl3N7O2Pureza:98.33%Forma y color:SolidPeso molecular:638.98TASIN-1
CAS:TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).Fórmula:C18H28N2O3SPureza:98.48%Forma y color:SolidPeso molecular:352.49Ref: TM-T22632
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)92,00€GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Fórmula:C24H29Cl2N3OPureza:98.44%Forma y color:SolidPeso molecular:446.41Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Fórmula:C18H15N5OPureza:97.03%Forma y color:SolidPeso molecular:317.34Ref: TM-T21981
1mg64,00€2mg96,00€5mg145,00€10mg212,00€25mg353,00€50mg532,00€100mg792,00€200mg1.064,00€EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Forma y color:SolidPeso molecular:581.47Ref: TM-T6483
1mg47,00€5mg92,00€10mg136,00€25mg259,00€50mg472,00€100mg677,00€200mg934,00€1mL*10mM (DMSO)107,00€(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFórmula:C72H99F3N20O23Pureza:98%Forma y color:SolidPeso molecular:1669.67H1k
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.Fórmula:C27H22N2OPureza:98.38%Forma y color:SoildPeso molecular:390.48Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Fórmula:C29H42N6O9Forma y color:SolidPeso molecular:618.68LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Fórmula:C29H48N12O12S2Pureza:100%Forma y color:SolidPeso molecular:820.89HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Fórmula:C19H23BrClN3O6Pureza:99.02% - 99.96%Forma y color:SolidPeso molecular:504.8Ref: TM-T8785
2mg42,00€5mg59,00€10mg94,00€25mg130,00€50mg207,00€100mg309,00€200mg462,00€1mL*10mM (DMSO)66,00€Amsilarotene
CAS:Amsilarotene (TAC101) blocks RB phosphorylation, boosts 2 CDK inhibitors, halts cell cycle, and reduces thymidylate synthase and cyclin A levels.Fórmula:C20H27NO3Si2Pureza:99.27%Forma y color:SolidPeso molecular:385.6Ref: TM-T21314
1mg43,00€2mg57,00€5mg96,00€10mg140,00€25mg273,00€50mg393,00€100mg560,00€200mg757,00€1mL*10mM (DMSO)96,00€ARRY 520 hydrochloride
CAS:'ARRY 520 hydrochloride: a KSP inhibitor causing apoptosis and strong anti-proliferative effects.'Fórmula:C20H23ClF2N4O2SPureza:98.06% - 99.26%Forma y color:SolidPeso molecular:456.94Ref: TM-TQ0318L
1mg59,00€5mg116,00€10mg170,00€25mg304,00€50mg437,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)149,00€
