Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Fórmula:C19H15ClFNO2SForma y color:SolidPeso molecular:375.84Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Forma y color:SolidPeso molecular:346.34Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Fórmula:C30H33Cl4N3O4Pureza:98%Forma y color:SolidPeso molecular:641.41Ascamycin
CAS:Ascamycin: a Streptomyces-made antibiotic targeting Xanthomonas spp. MIC: 0.4-12.5 μg/mL for X. citri, oryzae, and phage.Fórmula:C13H18ClN7O7SPureza:99.29%Forma y color:SolidPeso molecular:451.84Ref: TM-T14329
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)747,00€(E/Z)-ZINC09659342
CAS:(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.Fórmula:C23H15F3N2O4Pureza:95.83%Forma y color:SolidPeso molecular:440.37Ref: TM-T9986
1mg66,00€5mg145,00€10mg221,00€25mg378,00€50mg533,00€100mg718,00€200mg938,00€1mL*10mM (DMSO)160,00€Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFórmula:C18H16O8Pureza:99.50% - 99.85%Forma y color:SolidPeso molecular:360.315-BrdU
CAS:5-BrdU (Broxuridine) , a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.Fórmula:C9H11BrN2O5Pureza:99.54% - 99.87%Forma y color:Crystals From Absolute Ethanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:307.1Bersanlimab
CAS:Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:144.22 kDa5-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Fórmula:C8H12N4O5Pureza:99.31% - 99.79%Forma y color:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2(R)-Atuveciclib
CAS:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Fórmula:C18H18FN5O2SPureza:98%Forma y color:SolidPeso molecular:387.43αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Forma y color:SolidPeso molecular:672.67VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:98.31% - 99.72%Forma y color:SolidPeso molecular:400.04Ref: TM-T9168
1mg37,00€2mg52,00€5mg77,00€10mg96,00€25mg167,00€50mg240,00€100mg378,00€500mg889,00€1mL*10mM (DMSO)85,00€WRN inhibitor 15
WRN inhibitor 15 (Compound 9) is a WRN inhibitor with antitumor properties, displaying IC50 values of 37.9, 40.2, and 46.6 μM in PC3, LNCaP, and HeLa cells, respectively, making it suitable for prostate cancer research.Fórmula:C16H13F2N3OForma y color:SolidPeso molecular:301.29αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Forma y color:SolidPeso molecular:474.543'-Deoxy-3'-fluoroadenosine
CAS:3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with a wide range of anti-tumor and anti-viral activity, and has inhibitory effects on tick-borneFórmula:C10H12FN5O3Pureza:99.84%Forma y color:SolidPeso molecular:269.23Synucleozid hydrochloride
CAS:Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.Fórmula:C22H21ClN6Pureza:98.13%Forma y color:SolidPeso molecular:404.9CNDAC hydrochloride
CAS:CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.Fórmula:C10H13ClN4O4Pureza:99.69%Forma y color:SolidPeso molecular:288.69Ref: TM-T13621
1mg114,00€5mg274,00€10mg425,00€25mg702,00€50mg938,00€100mg1.311,00€1mL*10mM (DMSO)250,00€K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Fórmula:C13H15N3O2SPureza:100%Forma y color:SolidPeso molecular:277.34RX-3117
CAS:RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog.Fórmula:C10H12FN3O4Pureza:99.55%Forma y color:SolidPeso molecular:257.22Ref: TM-T16813
1mg157,00€2mg212,00€5mg309,00€10mg444,00€25mg728,00€50mg1.017,00€100mg1.378,00€1mL*10mM (DMSO)319,00€CDK7-IN-25
CAS:CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].Fórmula:C33H32N6O3Pureza:98%Forma y color:SolidPeso molecular:560.65Betamethasone 17-benzoate
CAS:Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).Fórmula:C29H33FO6Pureza:98%Forma y color:SolidPeso molecular:496.57CDK4-IN-2
CAS:CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Fórmula:C22H26F2N6O4SPureza:98%Forma y color:SolidPeso molecular:508.54CDK2-IN-20
CDK2-IN-20 (compound 3b), a CDK2 inhibitor, exhibits cytotoxic effects on tumor cells with an IC50 ranging from 5.52-17.09 µM.Pureza:98%Forma y color:Odour SolidCDK4/9-IN-1
CAS:CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.Fórmula:C22H34N6O2Forma y color:SolidPeso molecular:414.544Spartalizumab
CAS:"Spartalizumab (PDR001), a humanized IgG4 monoclonal antibody, targets PD-1 to inhibit PD-L1/L2 interactions, useful in ATC research."Pureza:SDS-PAGE:95.2%;SEC-HPLC:96.3%Forma y color:LiquidPeso molecular:145.74 kDaPurvalanol B
CAS:Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)Fórmula:C20H25ClN6O3Pureza:98.95%Forma y color:SolidPeso molecular:432.9Ref: TM-T7167
1mg38,00€5mg73,00€10mg95,00€25mg148,00€50mg215,00€100mg323,00€200mg487,00€1mL*10mM (DMSO)81,00€Visugromab
CAS:Visugromab, a GDF-15 neutralizing IgG4 monoclonal antibody (mAb), demonstrates potent efficacy in treating PD-1/PD-L1 relapsed/refractory metastatic solidPureza:98%Forma y color:LiquidN6-(p-Methoxybenzyl)adenosine
CAS:Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; plant growth regulator, plant hormoneFórmula:C18H21N5O5Pureza:99.79%Forma y color:SolidPeso molecular:387.39L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Fórmula:C5H13ClN2OSPureza:99.75%Forma y color:SolidPeso molecular:184.692'-O-(2-Methoxyethyl)adenosine
CAS:2'-O-(2-Methoxyethyl)adenosine is a nucleoside analog used to improve RNA target affinity and nuclease resistance of therapeutic oligonucleotides in preclin.Fórmula:C13H19N5O5Pureza:99.35%Forma y color:SolidPeso molecular:325.32Uridine triphosphate 13C9,15N2 sodium
CAS:Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.Fórmula:C9H1415N2NaO15P3Forma y color:SolidPeso molecular:517.04BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Fórmula:C22H20N4OPureza:96.7% - 99.43%Forma y color:SolidPeso molecular:356.42Ref: TM-T5405
1mg40,00€5mg88,00€10mg126,00€25mg240,00€50mg439,00€100mg647,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Nofazinlimab
CAS:Nofazinlimab (CS1003) is a human anti-PD-1 IgG4 monoclonal antibody for the study of unresectable hepatocellular carcinoma (uHCC).Forma y color:LiquidCDK9-IN-8
CAS:CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Fórmula:C31H32FN7O3Pureza:98.77%Forma y color:SolidPeso molecular:569.63RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Forma y color:SolidPeso molecular:361.61Ganciclovir sodium
CAS:Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.Fórmula:C9H13N5NaO4Pureza:99.47%Forma y color:SolidPeso molecular:278.226-Hydroxy-DOPA
CAS:6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.Fórmula:C9H11NO5Pureza:96.59% - 97.23%Forma y color:SolidPeso molecular:213.19Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:100% - 99.82%Forma y color:SolidPeso molecular:500.6Ref: TM-T2077
5mg48,00€10mg70,00€25mg86,00€50mg92,00€100mg116,00€200mg170,00€500mg274,00€1mL*10mM (DMSO)52,00€Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of upPureza:98.6%Forma y color:LiquidPeso molecular:143.7 kDaGSK2850163 (S enantiomer)
CAS:GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a).Fórmula:C24H29Cl2N3OPureza:98.40%Forma y color:SolidPeso molecular:446.41Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Fórmula:C28H43N9O7Pureza:100%Forma y color:SolidPeso molecular:617.7LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.Fórmula:C23H29ClN8OPureza:100%Forma y color:SolidPeso molecular:469.02Ref: TM-T4417
1mg59,00€2mg85,00€5mg97,00€10mg172,00€25mg339,00€50mg502,00€100mg728,00€1mL*10mM (DMSO)97,00€GRGDSPK
CAS:GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Fórmula:C28H49N11O11Pureza:98%Forma y color:SolidPeso molecular:715.76ZNL-05-044
ZNL-05-044, a CDK11 inhibitor, exhibits IC50 values of 0.23 μM for CDK11A and 0.27 μM for CDK11B, as determined by NanoBRET assay.Fórmula:C21H22Cl2N6OSPureza:98%Forma y color:SolidPeso molecular:477.41MDEG-541
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].Fórmula:C35H38N4O7SPureza:98%Forma y color:SolidPeso molecular:658.76TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Fórmula:C27H34F3N7O3Pureza:97.06%Forma y color:SolidPeso molecular:561.6Ref: TM-T7200
1mg64,00€2mg89,00€5mg120,00€10mg170,00€25mg294,00€50mg490,00€100mg710,00€1mL*10mM (DMSO)170,00€BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Fórmula:C16H22N6OPureza:99.69%Forma y color:SolidPeso molecular:314.39Ref: TM-T23820
2mg52,00€5mg111,00€10mg175,00€25mg321,00€50mg512,00€100mg825,00€200mg1.111,00€1mL*10mM (DMSO)47,00€UNC9512
UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editingFórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64(E/Z)-Rigosertib sodium
CAS:ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay).Fórmula:C21H24NNaO8SPureza:97.16% - 99.82%Forma y color:SolidPeso molecular:473.47CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Fórmula:C23H25ClN8OSPureza:98.14%Forma y color:SolidPeso molecular:497.02Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:99.94%Forma y color:SolidPeso molecular:416.51p21PBP
p21PBP, a peptide composed of 20 amino acids, serves as an inhibitor of DNA replication. It specifically binds to the purified proliferating cell nuclear antigen (PCNA) found in extracts from tumor cells. p21PBP holds potential for use in cancer research.Fórmula:C112H181N37O30SForma y color:SolidPeso molecular:2557.93Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Fórmula:C14H11BrN4O3SPureza:98.38%Forma y color:SolidPeso molecular:395.23Ref: TM-T36933
1mg103,00€2mg140,00€5mg202,00€10mg305,00€25mg512,00€50mg730,00€100mg998,00€500mg1.977,00€IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Fórmula:C24H28N4O4Pureza:97.59% - 98.69%Forma y color:SolidPeso molecular:436.5YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.Fórmula:C16H18ClN5Forma y color:SolidPeso molecular:315.80PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Fórmula:C19H28N6O4Pureza:98.61%Forma y color:SolidPeso molecular:404.46Ref: TM-T9712
1mg354,00€2mg518,00€5mg823,00€10mg1.206,00€25mg1.795,00€50mg2.422,00€100mg3.258,00€1mL*10mM (DMSO)914,00€2'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.35%Forma y color:SolidPeso molecular:269.23BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:98.77% - 99.55%Forma y color:SolidPeso molecular:345.34Ref: TM-T2679
1mg35,00€5mg74,00€10mg116,00€25mg221,00€50mg335,00€100mg480,00€200mg652,00€1mL*10mM (DMSO)82,00€2'-Deoxy-5,6-dihydrouridine
CAS:2'-Deoxy-5,6-dihydrouridine is a nucleoside analog that contains a dihydro group in its molecular structure,commonly used in base excision related studies.Fórmula:C9H14N2O5Pureza:99.75%Forma y color:SolidPeso molecular:230.229-(β-D-Xylofuranosyl)adenine
CAS:9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine hasFórmula:C10H13N5O4Pureza:99.55%Forma y color:SolidPeso molecular:267.24PVZB1194
CAS:PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFórmula:C13H9F4NO2SPureza:98%Forma y color:SolidPeso molecular:319.28(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Fórmula:C24H25Cl2F3N4OPureza:98%Forma y color:SolidPeso molecular:513.38(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Fórmula:C19H18F2N4O2SPureza:99.29%Forma y color:SolidPeso molecular:404.43Ref: TM-T13467
1mg37,00€5mg88,00€10mg120,00€25mg216,00€50mg354,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)87,00€CDK9 inhibitor HH1
CAS:CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.Fórmula:C13H15N3OSPureza:97.97%Forma y color:SolidPeso molecular:261.34RP-6306
CAS:Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.Fórmula:C18H20N4O2Pureza:98.41% - 99.28%Forma y color:SolidPeso molecular:324.38CDK2 degrader 3
CAS:CDK2 degrader3 selectively degrades CDK2 and exhibits antitumor activity.Fórmula:C44H53ClN10O6SForma y color:SolidPeso molecular:885.47Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Fórmula:C26H34N8OPureza:99%Forma y color:SolidPeso molecular:474.6360A
CAS:360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).Fórmula:C27H23N5O2Pureza:98.68%Forma y color:SolidPeso molecular:449.5Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Fórmula:C13H14Cl3N7O4Pureza:96.74%Forma y color:SolidPeso molecular:438.65Ref: TM-T8561
1mg48,00€2mg63,00€5mg87,00€10mg140,00€25mg274,00€50mg472,00€100mg710,00€1mL*10mM (DMSO)97,00€Rosnilimab
CAS:Rosnilimab is a humanized IgG1-κ antibody that targets PD-1 [1] [2].Pureza:98%Forma y color:LiquidEHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Fórmula:C25H30N6OPureza:100% - 99.86%Forma y color:SolidPeso molecular:430.55Ref: TM-T2427
5mg48,00€10mg73,00€25mg127,00€50mg213,00€100mg334,00€200mg492,00€500mg787,00€1mL*10mM (DMSO)52,00€YJ1206
CAS:YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader oral, DNA damage and cell-cycle arrest,and inhibits the proliferation of prostate cancer cells.Fórmula:C49H52FN11O5Pureza:97.14%Forma y color:SolidPeso molecular:894.01MBM-17S
CAS:MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest andFórmula:C36H40N6O10Pureza:98%Forma y color:SolidPeso molecular:716.74WRN inhibitor 2
CAS:WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Fórmula:C15H11F3N2O5S2Pureza:98%Forma y color:SolidPeso molecular:420.38DMT-dG(ib) Phosphoramidite
CAS:DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.Fórmula:C44H54N7O8PPureza:99.74%Forma y color:SolidPeso molecular:839.92SU-9516
CAS:SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.Fórmula:C13H11N3O2Pureza:99.59%Forma y color:SolidPeso molecular:241.25Ref: TM-T8819
1mg90,00€5mg131,00€10mg170,00€25mg248,00€50mg321,00€100mg419,00€500mg938,00€1mL*10mM (DMSO)117,00€Aaptamine
CAS:Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.Fórmula:C13H12N2O2Pureza:98%Forma y color:SolidPeso molecular:228.25c-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFórmula:C20H22N6OPureza:98%Forma y color:SolidPeso molecular:362.43AI-10-49
CAS:AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.Fórmula:C30H22F6N6O5Pureza:97.14%Forma y color:SolidPeso molecular:660.52Ref: TM-T6753
2mg40,00€5mg60,00€10mg96,00€25mg169,00€50mg245,00€100mg361,00€200mg512,00€1mL*10mM (DMSO)88,00€SR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Fórmula:C16H20ClN3O4SPureza:99.78%Forma y color:SoildPeso molecular:385.87Ref: TM-T60037
5mg39,00€10mg64,00€25mg117,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)62,00€SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Fórmula:C31H34Cl2N2O3Pureza:95.58% - 99.70%Forma y color:SolidPeso molecular:553.52Ref: TM-T2255
1mg42,00€5mg106,00€10mg163,00€25mg278,00€50mg429,00€100mg657,00€500mg1.501,00€1mL*10mM (DMSO)130,00€13-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23DL-Alanosine
CAS:DL-Alanosine is an amino acid analog with antitumor activity.Fórmula:C3H7N3O4Forma y color:SolidPeso molecular:149.105Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Fórmula:C6H11N3O4Pureza:98.81%Forma y color:SolidPeso molecular:189.17AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Forma y color:SolidPeso molecular:545.61PD-1-IN-17
CAS:PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Fórmula:C13H22N6O7Pureza:99.6%Forma y color:SolidPeso molecular:374.35PD-L1-IN-2
CAS:PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Fórmula:C33H38N4O6Pureza:98%Forma y color:SolidPeso molecular:586.68Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Fórmula:C6H14ClN3O5S2Forma y color:SolidPeso molecular:307.785-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Fórmula:C9H12FN2O9PForma y color:SolidPeso molecular:342.172AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Fórmula:C16H12N8OForma y color:SolidPeso molecular:332.32KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33Ref: TM-T9446
1mg96,00€2mg143,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)249,00€2-Keto-D-galactose
CAS:2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.Fórmula:C6H10O6Pureza:98%Forma y color:SolidPeso molecular:178.14Zn(BQTC)
CAS:Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.Fórmula:C30H36Cl2N5O3ZnPureza:98%Forma y color:SolidPeso molecular:650.92Ocifisertib(CFI-400945 free base)
CAS:Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase 4.Cost-effective and quality-assured.Fórmula:C33H34N4O3Pureza:97.56% - 98.53%Forma y color:SolidPeso molecular:534.65ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Forma y color:SolidPeso molecular:711.67Eciruciclib
CAS:Eciruciclib is an inhibitor of CDK with antitumor properties.Fórmula:C27H33FN8Pureza:97.51%Forma y color:SolidPeso molecular:488.6IBR2
CAS:IBR2 is a potent RAD51 inhibitor that disrupts DNA repair, inhibits cancer cell growth, and induces apoptosis.Fórmula:C24H20N2O2SPureza:96.15%Forma y color:SolidPeso molecular:400.49Ref: TM-T11600
1mg35,00€5mg70,00€10mg111,00€25mg183,00€50mg259,00€100mg359,00€200mg532,00€1mL*10mM (DMSO)77,00€Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Fórmula:C22H36N2O5SPureza:99.87%Forma y color:SolidPeso molecular:440.6Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Fórmula:C15H17FN4O3Pureza:98.68% - 99.89%Forma y color:Off-White To Yellow CrystalsPeso molecular:320.32
