Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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CDK9-IN-9
CAS:CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Fórmula:C22H23F2N5O2SPureza:98%Forma y color:SolidPeso molecular:459.51GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Fórmula:C32H38ClN5O4Pureza:96.22% - 98.02%Forma y color:SolidPeso molecular:592.13Ref: TM-T2039
1mg49,00€2mg70,00€5mg97,00€10mg168,00€25mg331,00€50mg510,00€100mg737,00€1mL*10mM (DMSO)136,00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Fórmula:C18H19NO3Pureza:99.19%Forma y color:SolidPeso molecular:297.35GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Fórmula:C29H37N5O2xHClPureza:99.54%Forma y color:SolidPeso molecular:0LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Fórmula:C10H12N4O4SPureza:98%Forma y color:SolidPeso molecular:284.29(R)-Enitociclib
CAS:(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Fórmula:C19H18F2N4O2SPureza:98.82%Forma y color:SoildPeso molecular:404.43CX-5461
CAS:CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Fórmula:C27H27N7O2SPureza:95.44% - 99.25%Forma y color:SolidPeso molecular:513.61IRE1α kinase-IN-1
CAS:IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.Fórmula:C26H26ClFN8Pureza:99.18%Forma y color:SolidPeso molecular:504.99Ref: TM-T9564
1mg116,00€5mg283,00€10mg452,00€25mg707,00€50mg1.017,00€100mg1.406,00€1mL*10mM (DMSO)311,00€CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Fórmula:C9H6N2O4Pureza:98.27% - 98.98%Forma y color:Brown PowderPeso molecular:206.15INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.21%Forma y color:SolidPeso molecular:693.79Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Fórmula:C21H16ClN3O4Forma y color:SolidPeso molecular:409.82BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Fórmula:C11H16BrN2O14P3Pureza:98%Forma y color:SolidPeso molecular:573.08Tirofiban hydrochloride monohydrate
CAS:Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Fórmula:C22H39ClN2O6SPureza:95.83% - 99.94%Forma y color:White SolidPeso molecular:495.07S-Gem
CAS:S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.Fórmula:C13H15F2N3O6S2Pureza:98%Forma y color:SolidPeso molecular:411.4CBFβ Inhibitor
CAS:CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Fórmula:C12H14N2OSPureza:96.50%Forma y color:SolidPeso molecular:234.32Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFórmula:C21H22N4OSPureza:98%Forma y color:SolidPeso molecular:378.49Poly(A) polymerase
CAS:Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.Pureza:98%Forma y color:Solid5-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Fórmula:C5H3FN2O4Pureza:100% - 99.7%Forma y color:White To Pale Yellow PowderPeso molecular:174.09MU147
CAS:MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Fórmula:C19H13N3O3SForma y color:SolidPeso molecular:363.39Deoxythymidine triphosphate
CAS:Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Fórmula:C10H14N2Na3O14P3Pureza:96.00%Forma y color:White Amorphous PowderPeso molecular:548.11PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Fórmula:C14H15NO2S2Pureza:98.20% - 99.98%Forma y color:SolidPeso molecular:293.4TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Fórmula:C21H17N3O3Pureza:99.68%Forma y color:SolidPeso molecular:359.38Ref: TM-T17008
1mg57,00€2mg84,00€5mg125,00€10mg188,00€25mg354,00€50mg532,00€100mg712,00€500mgA consultar1mL*10mM (DMSO)138,00€Metarrestin
CAS:Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Fórmula:C31H30N4OPureza:99.45%Forma y color:SolidPeso molecular:474.6Ref: TM-T12006
1mg40,00€2mg52,00€5mg88,00€10mg144,00€25mg298,00€50mg512,00€100mg740,00€500mg1.539,00€RG7800 tetrahydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.Fórmula:C24H32Cl4N6OPureza:98%Forma y color:SolidPeso molecular:562.362'-Deoxy-N4-methylcytidine
CAS:2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Fórmula:C10H15N3O4Pureza:99.61%Forma y color:SolidPeso molecular:241.24HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Forma y color:SolidPeso molecular:382.43Ref: TM-T3643
1mg43,00€2mg56,00€5mg88,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)79,00€SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Fórmula:C19H15F3N6O2Forma y color:SolidPeso molecular:416.36APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Fórmula:C17H16N8Pureza:96.51% - 98.46%Forma y color:SolidPeso molecular:332.36Ref: TM-T3654
2mg43,00€5mg65,00€10mg96,00€25mg177,00€50mg301,00€100mg543,00€500mg1.130,00€1mL*10mM (DMSO)71,00€Budigalimab
CAS:Budigalimab (ABBV 181) is a humanized monoclonal antibody targeting PD-1 with potential antitumor activity.Pureza:95% - 95%Forma y color:LiquidHomouridine
CAS:Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Fórmula:C10H14N2O6Pureza:98%Forma y color:SolidPeso molecular:258.23CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Fórmula:C22H26N4OPureza:98.21%Forma y color:SolidPeso molecular:362.47Avelumab
CAS:Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.Pureza:95% - 98.3% (SEC-HPLC)Forma y color:LiquidPeso molecular:143.8 kDaDatelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Fórmula:C23H28ClN3OPureza:98%Forma y color:SolidPeso molecular:397.94CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:98.07%Forma y color:SolidPeso molecular:328.35Ref: TM-T9615
1mg52,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)139,00€Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.63%Forma y color:SolidPeso molecular:587.54Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Fórmula:C17H19N5OSPureza:99.82% - 99.93%Forma y color:SolidPeso molecular:341.43Ref: TM-T12642L
1mg74,00€2mg96,00€5mg180,00€10mg250,00€25mg465,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)187,00€Acrixolimab
CAS:Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].Pureza:98%Forma y color:Liquid6-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Fórmula:C10H12N4O4SPureza:97.74%Forma y color:SolidPeso molecular:284.29Ref: TM-T7621
2mg51,00€5mg85,00€10mg119,00€25mg150,00€50mg188,00€100mg283,00€200mg432,00€1mL*10mM (DMSO)99,00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:98.00%Forma y color:LiquidPeso molecular:N/AKJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Fórmula:C22H15N3O4Pureza:98.07% - ≥98%Forma y color:SolidPeso molecular:385.37Ref: TM-T15665
2mg39,00€5mg57,00€10mg81,00€25mg145,00€50mg279,00€100mg510,00€200mg683,00€500mg1.064,00€1mL*10mM (DMSO)63,00€DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.Fórmula:C26H18ClN3O2Pureza:98%Forma y color:SolidPeso molecular:439.89IXA6
CAS:IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Fórmula:C22H20ClN3O3SPureza:98.63%Forma y color:SolidPeso molecular:441.93CW-069
CAS:CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Fórmula:C23H21IN2O3Pureza:97.52% - 98.59%Forma y color:SolidPeso molecular:500.33Ref: TM-T6209
1mg43,00€5mg90,00€10mg125,00€25mg216,00€50mg306,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)89,00€DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Fórmula:C19H14BrN5OPureza:98%Forma y color:SolidPeso molecular:408.25Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.Fórmula:C21H22N4O5Pureza:99.25%Forma y color:SolidPeso molecular:410.42ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Fórmula:C20H19N3O3Pureza:99.13%Forma y color:SolidPeso molecular:349.38Ref: TM-T72024
5mg39,00€10mg58,00€25mg105,00€50mg170,00€100mg271,00€200mg398,00€1mL*10mM (DMSO)52,00€Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:97.81%Forma y color:SolidPeso molecular:451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Fórmula:C27H26N6OPureza:99.67%Forma y color:SolidPeso molecular:450.53Ref: TM-T8430
1mg97,00€2mg131,00€5mg188,00€10mg305,00€25mg487,00€50mg655,00€100mg905,00€1mL*10mM (DMSO)215,00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Forma y color:SolidPeso molecular:378.27CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Fórmula:C21H23ClN6OPureza:97.74%Forma y color:SolidPeso molecular:410.9Ref: TM-T14901
1mg95,00€5mg221,00€10mg324,00€25mg548,00€50mg785,00€100mg1.074,00€1mL*10mM (DMSO)202,00€PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].Fórmula:C30H36N4O6S2Pureza:98%Forma y color:SolidPeso molecular:612.76BMS-1001 hydrochloride
CAS:BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effectFórmula:C35H35ClN2O7Pureza:97.36%Forma y color:SolidPeso molecular:631.11Ref: TM-T10565
1mg56,00€5mg127,00€10mg197,00€25mg401,00€50mg645,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)172,00€ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Forma y color:SolidPeso molecular:584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€CID 5951923
CAS:CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.Fórmula:C16H18N2O7SPureza:100.00%Forma y color:SolidPeso molecular:382.39Barasertib-HQPA
CAS:Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Forma y color:SolidPeso molecular:507.56TH588
CAS:TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.Fórmula:C13H12Cl2N4Pureza:96.05% - 99.82%Forma y color:SolidPeso molecular:295.17AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.79%Forma y color:SolidPeso molecular:442.32Ref: TM-T10215
1mg95,00€5mg202,00€10mg303,00€25mg550,00€50mg825,00€100mg1.198,00€1mL*10mM (DMSO)233,00€Palbociclib monohydrochloride
CAS:Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinasesFórmula:C24H29N7O2·HClPureza:100% - 99.91%Forma y color:SolidPeso molecular:483.99JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:100% - 99.96%Forma y color:SolidPeso molecular:505.08LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.17%Forma y color:SolidPeso molecular:453.34Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Forma y color:SolidPeso molecular:588.66Ref: TM-T2494
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg274,00€50mg439,00€100mg632,00€1mL*10mM (DMSO)137,00€Mirvetuximab
CAS:Mirvetuximab, a monoclonal antibody targeting FOLR1/FRα, treats ovarian and FRα-positive cancers, often paired with platinum-based drugs.Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:148 kDa (average)Ispinesib
CAS:Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFórmula:C30H33ClN4O2Pureza:98% - 98.59%Forma y color:SolidPeso molecular:517.06Ref: TM-T2103
1mg39,00€2mg50,00€5mg79,00€10mg118,00€25mg210,00€50mg339,00€100mg557,00€500mg1.216,00€1mL*10mM (DMSO)89,00€CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Fórmula:C19H18N4O4S2Pureza:98%Forma y color:SolidPeso molecular:430.5Werner syndrome RecQ helicase-IN-1
CAS:Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomachFórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Forma y color:SolidPeso molecular:702.08Ref: TM-T72107
1mg60,00€5mg125,00€10mg177,00€25mg296,00€50mg502,00€100mg803,00€500mg1.795,00€1mL*10mM (DMSO)822,00€CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Fórmula:C24H30N6O2Forma y color:SolidPeso molecular:434.53Folinic Acid Calcium Salt Pentahydrate
CAS:Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.Fórmula:C20H21CaN7O7·5H2OPureza:100% - 99.17%Forma y color:Yellowish-White To Yellow PowderPeso molecular:601.58NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Fórmula:C23H19N3O4SPureza:98.03% - 99.46%Forma y color:SolidPeso molecular:433.48Ref: TM-T8886
1mg74,00€5mg170,00€10mg274,00€25mg472,00€50mg655,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)188,00€GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Fórmula:C27H32N6OPureza:99.57%Forma y color:SolidPeso molecular:456.58N6,N6-Dimethyladenosine
CAS:N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.Fórmula:C12H17N5O4Pureza:98.79%Forma y color:White PowderPeso molecular:295.29Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Fórmula:C21H18F3N5OPureza:98.91%Forma y color:SolidPeso molecular:413.4Ref: TM-T5524
1mg78,00€2mg97,00€5mg188,00€10mg298,00€25mg500,00€50mg710,00€100mg938,00€200mg1.311,00€1mL*10mM (DMSO)215,00€HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Fórmula:C24H27FN4O5Forma y color:SolidPeso molecular:470.49RG7800
CAS:RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.Fórmula:C24H28N6OPureza:99.44%Forma y color:SolidPeso molecular:416.52ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Fórmula:C21H21F3N4O2Pureza:99.18%Forma y color:SolidPeso molecular:418.41PD-1/PD-L1-IN-NP19
CAS:PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Fórmula:C33H31ClN2O4Pureza:98%Forma y color:SolidPeso molecular:555.06Doxifluridine
CAS:Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.Fórmula:C9H11FN2O5Pureza:99.47% - 99.86%Forma y color:White SolidPeso molecular:246.192′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Fórmula:C10H12FN5O4Pureza:99.82%Forma y color:SolidPeso molecular:285.23Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Fórmula:C21H22N4O6SPureza:98.99% - 99.06%Forma y color:Yellow Crystalline PowderPeso molecular:458.49SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Fórmula:C20H26N8OSPureza:98%Forma y color:SolidPeso molecular:426.54Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.10% - 99.33%Forma y color:SolidPeso molecular:558.7AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potentFórmula:C23H28FN7OPureza:98.01%Forma y color:SolidPeso molecular:437.51Ref: TM-T21544
1mg57,00€5mg120,00€10mg187,00€25mg416,00€50mg655,00€100mg924,00€1mL*10mM (DMSO)144,00€Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Fórmula:C26H42N4O5Pureza:98.82%Forma y color:SolidPeso molecular:490.64T4 RNA ligase
T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA.Pureza:98%Forma y color:Odour SolidMonastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Fórmula:C14H16N2O3SPureza:98.59% - 99.19%Forma y color:SolidPeso molecular:292.35Ref: TM-T4048
1mg48,00€5mg78,00€10mg97,00€25mg188,00€50mg311,00€100mg502,00€500mg1.074,00€1mL*10mM (DMSO)87,00€Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.Fórmula:C19H22FN3O3Pureza:100% - 99.89%Forma y color:Pale Yellow CrystalsPeso molecular:359.39PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Fórmula:C20H27F2N5O4SPureza:98.77% - 99.58%Forma y color:SolidPeso molecular:471.52Ref: TM-T8463
1mg57,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)131,00€Zimberelimab
CAS:Zimberelimab (GLS-010) is a humanized antibody targeting PD-1, with anticancer activity.Pureza:95%Forma y color:Liquid7-Methylguanosine
CAS:7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Fórmula:C11H16N5O5Pureza:98.11%Forma y color:SolidPeso molecular:298.282′-O-Methylcytidine
CAS:2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.Fórmula:C10H15N3O5Pureza:99.81%Forma y color:SolidPeso molecular:257.24Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Fórmula:C25H22ClFN6O2SPureza:98.34%Forma y color:SolidPeso molecular:525TK216
CAS:TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Fórmula:C19H15Cl2NO3Pureza:97.22%Forma y color:SolidPeso molecular:376.23(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Fórmula:C14H16N2O3SPureza:98%Forma y color:SolidPeso molecular:292.356-Mercaptopurine
CAS:6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Fórmula:C5H4N4SPureza:99.53% - 99.63%Forma y color:Yellow Crystalline Powder SolidPeso molecular:152.18KIF18A-IN-15
CAS:KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Fórmula:C25H33F3N6O5SForma y color:SolidPeso molecular:586.63Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Fórmula:C22H20Cl2F3NO5Pureza:98%Forma y color:SolidPeso molecular:506.33-Methylcytidine
CAS:3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.Fórmula:C10H15N3O5Pureza:98%Forma y color:SolidPeso molecular:257.24Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Fórmula:C20H20N6O4SPureza:98.17%Forma y color:SolidPeso molecular:440.48CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Fórmula:C17H11ClN2OPureza:98.41%Forma y color:SoildPeso molecular:294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Forma y color:SolidPeso molecular:422.52Ref: TM-T16359
2mg42,00€5mg64,00€10mg97,00€25mg187,00€50mg301,00€100mg437,00€200mg612,00€1mL*10mM (DMSO)71,00€Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Fórmula:C26H25ClN4O2Pureza:98.5%Forma y color:SolidPeso molecular:460.96Etaracizumab
CAS:Etaracizumab (LM 609) is a humanized monoclonal antibody targeting integrin αvβ3, inhibiting angiogenesis and melanoma growth, used in the study of melanoma.Pureza:>95% - >95%Forma y color:LiquidPeso molecular:144.3 (kDa)PT-129
PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.Fórmula:C46H48N8O12SForma y color:SolidPeso molecular:936.98Dihydrobaicalein
CAS:Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2.Fórmula:C15H12O5Pureza:99.86%Forma y color:SolidPeso molecular:272.25SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Forma y color:SolidPeso molecular:527.04Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Fórmula:C27H21N3O3Pureza:96.25%Forma y color:SolidPeso molecular:435.47Ref: TM-T35570
1mg90,00€5mg187,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€LDC4297
CAS:LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.Fórmula:C23H28N8OPureza:98.25%Forma y color:SolidPeso molecular:432.52N2-Isobutyryl-2-deoxyguanosine
CAS:N2-Isobutyryl-2-deoxyguanosine(iBu-dG) is a nucleoside analog that can be used to synthesize oligonucleotides.Fórmula:C14H19N5O5Pureza:97.03%Forma y color:SolidPeso molecular:337.33GS-9191
CAS:GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , whichFórmula:C37H51N8O6PPureza:98.01% - 98.28%Forma y color:SolidPeso molecular:734.82Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Fórmula:C23H20N4O3Pureza:98.66%Forma y color:SolidPeso molecular:400.43Ref: TM-T9040
1mg66,00€5mg145,00€10mg212,00€25mg380,00€50mg562,00€100mg832,00€200mg1.121,00€1mL*10mM (DMSO)167,00€αvβ1 integrin-IN-2
CAS:αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Fórmula:C29H38N4O4Pureza:98%Forma y color:SolidPeso molecular:506.64AZ3146
CAS:AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.Fórmula:C24H32N6O3Pureza:100% - 97.84%Forma y color:SolidPeso molecular:452.55Palmatine
CAS:Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Fórmula:C21H22NO4Pureza:96.28% - 99.49%Forma y color:SolidPeso molecular:352.4αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Fórmula:C21H30N4O3Pureza:98%Forma y color:SolidPeso molecular:386.49OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Fórmula:C30H30F3N5OPureza:98.03%Forma y color:SolidPeso molecular:533.59Ref: TM-T5485
1mg97,00€2mg144,00€5mg235,00€10mg378,00€25mg647,00€50mg920,00€100mg1.225,00€500mg2.498,00€1mL*10mM (DMSO)306,00€Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Fórmula:C24H25N7OPureza:100% - 100%Forma y color:SolidPeso molecular:427.5Taq DNA polymerase
CAS:Taq DNA polymerase is a thermostable enzyme utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].Pureza:98%Forma y color:SolidPRT4165
CAS:PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.Fórmula:C15H9NO2Pureza:98.91% - 99.6%Forma y color:SolidPeso molecular:235.24Ref: TM-T3110
5mg46,00€10mg51,00€25mg93,00€50mg118,00€100mg192,00€200mg268,00€500mg452,00€1mL*10mM (DMSO)49,00€(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Fórmula:C29H30Cl2N6O2Pureza:98.36%Forma y color:SolidPeso molecular:565.5AUNP-12 acetate
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in additionFórmula:C144H230N40O50Pureza:95.07%Forma y color:SolidPeso molecular:3321.61PD-1/PD-L1-IN-53
CAS:PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.Fórmula:C31H37N3O4Forma y color:SolidPeso molecular:515.64Cyclo(-RGDfK)
CAS:Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Fórmula:C27H41N9O7Pureza:100% - 99.83%Forma y color:SolidPeso molecular:603.67NKP-1339
CAS:NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.Fórmula:C14H12Cl4N4NaRuPureza:98%Forma y color:SolidPeso molecular:502.14MTH1 ligand 1
CAS:MTH1 ligand 1 functions as a target protein ligand for MTH1, and is utilized in the synthesis of PROTACaTAG 2139.Fórmula:C23H18N4O3Forma y color:SolidPeso molecular:398.41Rafoxanide
CAS:Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.Fórmula:C19H11Cl2I2NO3Pureza:99.47%Forma y color:Slight Yellowish Brown Injectable Solution &White Oral SolutionPeso molecular:626.01ddUTP Lithium
ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids.Pureza:98%Forma y color:Odour SolidCSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Fórmula:C48H50F9N7O7SForma y color:SolidPeso molecular:1040D-F07
CAS:D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.Fórmula:C18H21NO6Pureza:99.30% - 99.47%Forma y color:SoildPeso molecular:347.36PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:419.48SR31527
CAS:SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.Fórmula:C15H14ClN3OSPureza:98%Forma y color:SolidPeso molecular:319.81Nolatrexed dihydrochloride
CAS:Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.Fórmula:C14H14Cl2N4OSPureza:97.02%Forma y color:Tan SolidPeso molecular:357.26SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Fórmula:C25H20FN7OPureza:97.82%Forma y color:SolidPeso molecular:453.47Ref: TM-T8685
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)177,00€KIRA6
CAS:KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.Fórmula:C28H25F3N6OPureza:97.91%Forma y color:SolidPeso molecular:518.53MKLP2-IN-1
CAS:MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.Fórmula:C23H19BrFN3O2Forma y color:SolidPeso molecular:468.318TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:97.38% - 99.1%Forma y color:SolidPeso molecular:504.64BLU-222
CAS:BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.Fórmula:C15H17F2N7O2Pureza:99.25% - 99.88%Forma y color:SoildPeso molecular:365.34Ref: TM-T84321
1mg120,00€5mg283,00€10mg502,00€25mg937,00€50mg1.264,00€100mg1.700,00€1mL*10mM (DMSO)319,00€CLK1/2-IN-3
CAS:CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Fórmula:C21H21N5O2Pureza:98.71%Forma y color:SolidPeso molecular:375.42PTC-209
CAS:PTC-209 is a potent and selective BMI-1 inhibitor.Fórmula:C17H13Br2N5OSPureza:99.43% - 99.60%Forma y color:SolidPeso molecular:495.19MLS000532223
CAS:MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Fórmula:C15H9NO3Pureza:98.60%Forma y color:SolidPeso molecular:251.24Ref: TM-T8473
1mg130,00€2mg183,00€5mg306,00€10mg462,00€25mg755,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)319,00€E7820
CAS:E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Fórmula:C17H12N4O2SPureza:98.31% - 99.11%Forma y color:SolidPeso molecular:336.37Ref: TM-T4435
1mg35,00€2mg52,00€5mg69,00€10mg88,00€25mg144,00€50mg210,00€100mg339,00€200mg502,00€1mL*10mM (DMSO)85,00€Roniciclib
CAS:Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.Fórmula:C18H21F3N4O3SPureza:98% - 98.63%Forma y color:SolidPeso molecular:430.44BMVC-8C3O
CAS:BMVC-8C3O is a DNA G-quadruplex (G4) ligand.Cost-effective and quality-assured.Fórmula:C42H53I3N4O3Pureza:99.72%Forma y color:SolidPeso molecular:1042.61Ref: TM-T13584
1mg106,00€5mg202,00€10mg301,00€25mg487,00€50mg658,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)393,00€WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Fórmula:C30H31N5O3Forma y color:SolidPeso molecular:509.6RO0270608
CAS:RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Fórmula:C24H19Cl3N2O4Pureza:98.55%Forma y color:SolidPeso molecular:505.781A-116
CAS:1A-116 is a specific Rac1 inhibitor.Fórmula:C16H16F3N3Pureza:98.43%Forma y color:SolidPeso molecular:307.31Ref: TM-T14004
1mg50,00€5mg111,00€10mg166,00€25mg283,00€50mg444,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)123,00€MKC9989
CAS:MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.Fórmula:C17H20O7Pureza:99.30%Forma y color:SolidPeso molecular:336.34Ref: TM-T12071
1mg51,00€5mg156,00€10mg226,00€25mg376,00€50mg543,00€100mg730,00€1mL*10mM (DMSO)140,00€JH-RE-06
CAS:JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.Fórmula:C20H16Cl3N3O4Pureza:99.29%Forma y color:SolidPeso molecular:468.72Ref: TM-T15611
1mg47,00€5mg87,00€10mg160,00€25mg354,00€50mg620,00€100mg1.103,00€1mL*10mM (DMSO)90,00€CDK9-IN-23
CAS:CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Fórmula:C22H25ClN4O3Pureza:98%Forma y color:SolidPeso molecular:428.91LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Forma y color:SolidPeso molecular:309.3Ref: TM-T7810
1mg40,00€5mg85,00€10mg115,00€25mg224,00€50mg335,00€100mg502,00€200mg715,00€1mL*10mM (DMSO)92,00€ZN-c3
CAS:Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.Fórmula:C29H34N8O2Pureza:99.80%Forma y color:SolidPeso molecular:526.63Ref: TM-T9643
1mg96,00€5mg227,00€10mg354,00€25mg655,00€50mg1.035,00€100mg1.549,00€200mg2.080,00€1mL*10mM (DMSO)264,00€WRN inhibitor 1
CAS:WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.Fórmula:C16H13FN2O4SPureza:98%Forma y color:SolidPeso molecular:348.35Dithranol
CAS:Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especiallyFórmula:C14H10O3Pureza:93.49% - ≥98%Forma y color:Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingPeso molecular:226.23Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Fórmula:C26H25F2N7O6S2Pureza:98.76%Forma y color:SolidPeso molecular:633.65Zeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Fórmula:C18H20F3N4O2PForma y color:SolidPeso molecular:412.346CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Fórmula:C20H18N4OForma y color:SolidPeso molecular:330.38EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Fórmula:C25H24N2O4Pureza:98.51%Forma y color:SolidPeso molecular:416.47TAME
CAS:Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.Fórmula:C14H22N4O4SPureza:98%Forma y color:SolidPeso molecular:342.41Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFórmula:C24H26N4O5SPureza:99.00% - 99.86%Forma y color:SolidPeso molecular:482.55Ref: TM-T4226
1mg60,00€2mg79,00€5mg124,00€10mg197,00€25mg325,00€50mg505,00€100mg730,00€500mg1.501,00€1mL*10mM (DMSO)140,00€Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Fórmula:C21H22ClNO4Pureza:97.9% - 99.47%Forma y color:SolidPeso molecular:387.857Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Forma y color:SolidPeso molecular:385.85Ref: TM-T4321
1mg35,00€2mg46,00€5mg66,00€10mg93,00€25mg137,00€50mg210,00€100mg314,00€1mL*10mM (DMSO)72,00€TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Fórmula:C24H21Cl2NO5Pureza:98.98%Forma y color:SolidPeso molecular:474.33Ref: TM-T5310
1mg52,00€5mg105,00€10mg170,00€25mg298,00€50mg430,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)111,00€Tegafur
CAS:Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity.Fórmula:C8H9FN2O3Pureza:99.16% - 99.89%Forma y color:White Crystalline PowderPeso molecular:200.17BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Fórmula:C22H21FN6O5Forma y color:SolidPeso molecular:468.44Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Fórmula:C24H17ClF2N6O4Pureza:97.87% - 99.51%Forma y color:SolidPeso molecular:526.88Ref: TM-T4367
1mg49,00€5mg99,00€10mg168,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)116,00€TASIN-30
CAS:TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Fórmula:C18H30N2O3SForma y color:SolidPeso molecular:354.51ITX3
CAS:ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Fórmula:C22H17N3OSPureza:99.02%Forma y color:SolidPeso molecular:371.45GSK_WRN4
CAS:GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFórmula:C16H20N2O4SPureza:100%Forma y color:SolidPeso molecular:336.41Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:≥95%Forma y color:SolidPeso molecular:847.72Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Forma y color:SolidPeso molecular:384.45Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Fórmula:C23H16ClFN4OPureza:98.21%Forma y color:SolidPeso molecular:418.85ASC-69
CAS:ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Fórmula:C19H19N7Pureza:98%Forma y color:SolidPeso molecular:345.4T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Fórmula:C19H14F3N3O3Pureza:98.39% - 98.61%Forma y color:SolidPeso molecular:389.33IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Fórmula:C24H21ClFNO6Pureza:98.26% - 99.64%Forma y color:SolidPeso molecular:473.88Ref: TM-T8842
1mg145,00€5mg311,00€10mg533,00€25mg775,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)325,00€CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Fórmula:C18H18N4O2Pureza:97.07%Forma y color:SolidPeso molecular:322.36SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Fórmula:C25H20FN7OPureza:99.52%Forma y color:SolidPeso molecular:453.47Ref: TM-T41256
1mg73,00€5mg160,00€10mg250,00€25mg445,00€50mg625,00€100mg909,00€200mg1.216,00€1mL*10mM (DMSO)170,00€Valacyclovir hydrochloride
CAS:Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.Fórmula:C13H20N6O4·HClPureza:100% - ≥95%Forma y color:White To Off-White Crystalline PowerPeso molecular:360.8Ref: TM-T1087
1g299,00€10mg47,00€25mg69,00€50mg85,00€100mg97,00€200mg127,00€500mg202,00€1mL*10mM (DMSO)47,00€Netivudine
CAS:Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.Fórmula:C12H14N2O6Pureza:99.83%Forma y color:SolidPeso molecular:282.25GW779439X
CAS:GW779439X is an inhibitor of CDK.Fórmula:C22H21F3N8Pureza:97.87%Forma y color:SolidPeso molecular:454.45Ref: TM-T8866
1mg62,00€2mg87,00€5mg119,00€10mg188,00€25mg425,00€50mg625,00€100mg892,00€1mL*10mM (DMSO)131,00€Rinatabart
Rinatabart is a humanized IgG1κ antibody that targets FOLR1. The corresponding isotype control is HumanIgG1kappa, Isotype Control.Forma y color:Odour LiquidTHZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98%Forma y color:SolidPeso molecular:566.05RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Forma y color:SolidPeso molecular:410.41Ref: TM-T12783
1mg127,00€5mg311,00€10mg472,00€25mg747,00€50mg1.017,00€100mg1.311,00€200mg1.786,00€1mL*10mM (DMSO)344,00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Pureza:95% - 95%Forma y color:LiquidBMS202 hydrochloride (1675203-84-5(free base))
CAS:BMS202 hydrochloride (1675203-84-5) is a potent PD-1/PD-L1 inhibitor (IC50: 18 nM) that promotes PD-L1 dimerization, blocking PD1 binding.Fórmula:C25H30ClN3O3Pureza:99.47%Forma y color:SolidPeso molecular:455.97Ref: TM-T4696
1mg51,00€2mg63,00€5mg100,00€10mg160,00€25mg306,00€50mg548,00€100mg785,00€1mL*10mM (DMSO)100,00€CDK9/PARP-IN-1
CAS:CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Fórmula:C38H34F2N8O3Forma y color:SolidPeso molecular:688.725αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Forma y color:SolidPeso molecular:477.52Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:100%Forma y color:SoildPeso molecular:644.56Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Fórmula:C27H38N8O6Pureza:98%Forma y color:SolidPeso molecular:570.651CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Forma y color:SolidPeso molecular:408.46CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Fórmula:C30H23N5Forma y color:SolidPeso molecular:453.5411α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFórmula:C28H40O7Pureza:98%Forma y color:SolidPeso molecular:488.61Ara-G
CAS:Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.Fórmula:C10H13N5O5Pureza:99.93%Forma y color:Slightly Off White To White PowderPeso molecular:283.24Sorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Fórmula:C11H13BrN2O6Pureza:97.33%Forma y color:SolidPeso molecular:349.13Apcin A HCL
CAS:Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.Fórmula:C10H15Cl4N5O2Pureza:99.59%Forma y color:SolidPeso molecular:379.07AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Fórmula:C24H26F3N7O2Pureza:99.59%Forma y color:SolidPeso molecular:501.5Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Fórmula:C17H19F3N4O3SPureza:99.96%Forma y color:SolidPeso molecular:416.42WRN inhibitor 16
WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.Fórmula:C31H30F4N4O5SForma y color:SolidPeso molecular:646.65CDK9-IN-7
CAS:CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Fórmula:C29H37N7O2SPureza:98.19%Forma y color:SolidPeso molecular:547.71Ref: TM-T10745
1mg116,00€5mg298,00€10mg432,00€25mg652,00€50mg900,00€100mg1.206,00€500mg2.432,00€1mL*10mM (DMSO)325,00€Penpulimab
CAS:Penpulimab is a monoclonal antibody targeting PD-1 with antitumor activity, used in studies of pancreatic cancer.Pureza:95% - 95%Forma y color:LiquidTadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Forma y color:LiquidAurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Forma y color:SolidPeso molecular:529.97
