Ferroptosis
La ferroptosis es una forma de muerte celular regulada caracterizada por la acumulación de peróxidos lipídicos y el estrés oxidativo dependiente de hierro. A diferencia de la apoptosis, la ferroptosis no está impulsada por caspasas, sino por el fallo de las defensas antioxidantes celulares, lo que conduce a la muerte celular. Los inhibidores e inductores de la ferroptosis son fundamentales para estudiar esta vía única de muerte celular, que está implicada en diversas enfermedades, como el cáncer, la neurodegeneración y el daño por isquemia-reperfusión. En CymitQuimica, ofrecemos una amplia gama de moduladores de la ferroptosis de alta calidad para apoyar su investigación en mecanismos de muerte celular, estrés oxidativo y patología de enfermedades.
Productos de "Ferroptosis"
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L-Glutathione reduced
CAS:L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals.Fórmula:C10H17N3O6SPureza:97.37% - 99.97%Forma y color:SolidPeso molecular:307.32Tagitinin C
CAS:Tagitinin C is a sesquiterpene compound isolated from Tithonia diversifolia, an inducer of ferroptosis with anti-cancer activity.Fórmula:C19H24O6Forma y color:SolidPeso molecular:348.39TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Fórmula:C10H14O2Pureza:99.17% - 99.53%Forma y color:White Solid PowderPeso molecular:166.22Cycloheximide
CAS:Cycloheximide (Naramycin A) is an antimitotic compound and an inhibitor of DNA and protein synthesis.Fórmula:C15H23NO4Pureza:95.08% - 99.95%Forma y color:SolidPeso molecular:281.35L-Glutamic Acid
CAS:Fórmula:C5H9NO4Pureza:>99.0%(T)Forma y color:White powder to crystalPeso molecular:147.13Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Pureza:98%Forma y color:Odour SolidTrigonelline
CAS:Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.Fórmula:C7H7NO2Pureza:98% - 99.49%Forma y color:Prisms Aqueous From Alcohol + Water SolidPeso molecular:137.14GDCNF-11
CAS:GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Fórmula:C48H53Cl2N13O5SForma y color:SolidPeso molecular:994.99CDDO-Im
CAS:CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Fórmula:C34H43N3O3Pureza:100% - 98.3%Forma y color:SolidPeso molecular:541.72Ref: TM-TQ0120
1mg37,00€5mg79,00€10mg111,00€25mg210,00€50mg338,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)94,00€Rosiglitazone
CAS:Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.Fórmula:C18H19N3O3SPureza:98.61% - 99.87%Forma y color:White To Off-White Crystalline PowderPeso molecular:357.43Gallic acid
CAS:Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.Fórmula:C7H6O5Pureza:99.57%Forma y color:White Solid Solid Particulate/PowderPeso molecular:170.12Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Fórmula:C12H17NO2Pureza:97.72% - 99.41%Forma y color:SolidPeso molecular:207.27FA16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16Fórmula:C22H27F3N4O2SPureza:99.75%Forma y color:SolidPeso molecular:468.54Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Fórmula:C13H15NO2SPureza:99.76% - 99.83%Forma y color:White SolidPeso molecular:249.33Ref: TM-T1934
2mg35,00€5mg50,00€10mg66,00€25mg85,00€50mg124,00€100mg197,00€200mg255,00€1mL*10mM (DMSO)62,00€Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Fórmula:C17H19NO5Pureza:97.03% - 99.89%Forma y color:SolidPeso molecular:317.34Vamifeport
CAS:Vamifeport (VIT-2763), an inhibitor targeting iron transport proteins, improves anemia and erythropoiesis and can be studied β-thalassemiaFórmula:C21H21FN6O2Pureza:99.26%Forma y color:SolidPeso molecular:408.43Ref: TM-T39520
1mg115,00€5mg274,00€10mg432,00€25mg730,00€50mg1.026,00€100mg1.378,00€1mL*10mM (DMSO)303,00€(-)-Epigallocatechin Gallate
CAS:(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase.Fórmula:C22H18O11Pureza:98.08% - 99.43%Forma y color:Yellow PowderPeso molecular:458.37NADPH tetrasodium salt
CAS:NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety ofFórmula:C21H26N7Na4O17P3Pureza:100% - 99.65%Forma y color:SolidPeso molecular:833.35CP-24879 hydrochloride
CAS:CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.Fórmula:C11H18ClNOPureza:98.78%Forma y color:SolidPeso molecular:215.72Ref: TM-T27061
1mg49,00€5mg92,00€10mg145,00€25mg274,00€50mg472,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)96,00€GPX4-IN-7
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.Fórmula:C25H23ClN4O4Pureza:98%Forma y color:SolidPeso molecular:478.93
