CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Productos de "CDK"
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Amantadine hydrochloride
CAS:Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.Fórmula:C10H18ClNPureza:99.98%Forma y color:Solid CrystallinePeso molecular:187.71(S)-Enitociclib
CAS:(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.Fórmula:C19H18F2N4O2SPureza:98.04%Forma y color:SolidPeso molecular:404.43AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:100%Forma y color:SolidPeso molecular:405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€CDK8/19-IN-51
CAS:CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Fórmula:C23H22N6O2Pureza:100% - 98.65%Forma y color:SoildPeso molecular:414.46WAY-647802
CAS:WAY-647802 is a CDK inhibitor.Fórmula:C11H14N4O3Pureza:98.38%Forma y color:SolidPeso molecular:250.25Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Fórmula:C26H25ClN4O2Pureza:98.5%Forma y color:SolidPeso molecular:460.96THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:95.09% - 99.27%Forma y color:SolidPeso molecular:566.05CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Fórmula:C23H18N6O2SPureza:97.24% - 99.10%Forma y color:SolidPeso molecular:442.49Ref: TM-T14916
1mg87,00€5mg202,00€10mg321,00€25mg550,00€50mg753,00€100mg1.074,00€1mL*10mM (DMSO)240,00€ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44Ref: TM-T16391
1mg50,00€5mg74,00€10mg105,00€25mg182,00€50mg283,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)64,00€CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Fórmula:C16H21N7O2Forma y color:SolidPeso molecular:343.384Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.90%Forma y color:SolidPeso molecular:552.63Ref: TM-T15732
2mg35,00€5mg51,00€10mg73,00€25mg97,00€50mg115,00€100mg168,00€200mg271,00€500mg484,00€1mL*10mM (DMSO)64,00€BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Fórmula:C14H16N2OSPureza:99.68%Forma y color:SolidPeso molecular:260.35Ref: TM-T36964
5mg50,00€10mg85,00€25mg169,00€50mg279,00€100mg487,00€500mg1.035,00€1mL*10mM (DMSO)52,00€SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Fórmula:C15H18Br2N4Pureza:100% - 99.7%Forma y color:SolidPeso molecular:414.14CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Fórmula:C11H8F3N3OPureza:97.09%Forma y color:SolidPeso molecular:255.2Ref: TM-T10740
1mg87,00€5mg216,00€10mg311,00€25mg525,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)240,00€BGG463
CAS:BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Fórmula:C30H29F3N6O3Pureza:100% - 95.05%Forma y color:SolidPeso molecular:578.58Ref: TM-T4618
1mg62,00€2mg87,00€5mg119,00€10mg188,00€25mg350,00€50mg505,00€100mg730,00€1mL*10mM (DMSO)154,00€ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.39%Forma y color:SolidPeso molecular:293.28Ref: TM-T7426
1mg58,00€5mg116,00€10mg183,00€25mg313,00€50mg449,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)111,00€Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Fórmula:C19H26N6OPureza:97.15% - 99.88%Forma y color:White To Off-White SolidPeso molecular:354.45Samuraciclib hydrochloride
CAS:Samuraciclib HCl is an oral CDK7 inhibitor (IC50: 41 nM), 45-230x selective over CDK1/2/5/9, inhibiting breast cancer growth (GI50: 0.2-0.3 μM).Fórmula:C22H31ClN6OPureza:98.99% - 99.8%Forma y color:SolidPeso molecular:430.97Ref: TM-T10898
1mg114,00€5mg235,00€10mg376,00€25mg628,00€50mg894,00€100mg1.216,00€1mL*10mM (DMSO)259,00€NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:100% - 99.36%Forma y color:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg48,00€5mg97,00€10mg145,00€25mg269,00€50mg395,00€100mg563,00€200mg743,00€1mL*10mM (DMSO)99,00€ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.Fórmula:C19H17N3O3Pureza:100% - 98.85%Forma y color:SolidPeso molecular:335.36Ref: TM-T2670
2mg34,00€5mg49,00€10mg74,00€25mg142,00€50mg235,00€100mg349,00€200mg497,00€1mL*10mM (DMSO)49,00€
