DYRK
Los inhibidores de las quinasas DYRK (quinasas reguladas por fosforilación de tirosina de doble especificidad) son compuestos que se dirigen a la familia de quinasas DYRK, involucradas en la regulación del ciclo celular, el desarrollo neuronal y la apoptosis. Las quinasas DYRK tienen doble especificidad, lo que significa que pueden fosforilar residuos de tirosina y serina/treonina. Inhibir las quinasas DYRK puede afectar varios procesos celulares, incluida la progresión del ciclo celular y la diferenciación. Los inhibidores de DYRK son herramientas importantes en la investigación sobre cáncer, enfermedades neurodegenerativas y señalización celular. En CymitQuimica, ofrecemos una selección de inhibidores de DYRK de alta calidad para apoyar su investigación en el control del ciclo celular, neurobiología y desarrollo terapéutico.
Productos de "DYRK"
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DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Fórmula:C23H24FN7Forma y color:SolidPeso molecular:417.48AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Fórmula:C19H16N4Pureza:99.99%Forma y color:SolidPeso molecular:300.36Ref: TM-T14364
1mg47,00€5mg97,00€10mg156,00€25mg304,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)105,00€Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Fórmula:C23H23F5N8OForma y color:SolidPeso molecular:522.47Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Fórmula:C22H16FN3O2SForma y color:SolidPeso molecular:405.445CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Fórmula:C28H30N6O2Pureza:98.37%Forma y color:SolidPeso molecular:482.58CLK1-IN-3
CAS:Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.Fórmula:C24H23FN6OPureza:99.79%Forma y color:SoildPeso molecular:430.48ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Fórmula:C16H14N2O4Pureza:99.32%Forma y color:SolidPeso molecular:298.29LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Fórmula:C18H20N2O2SPureza:98.01% - 99.51%Forma y color:SolidPeso molecular:328.43Ref: TM-TQ0111
1mg78,00€5mg160,00€10mg250,00€25mg502,00€50mg730,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)170,00€Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Fórmula:C13H12N2OPureza:98.29% - 99.92%Forma y color:Off-White SolidPeso molecular:212.25GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Fórmula:C24H30N6O2Pureza:98.11%Forma y color:SolidPeso molecular:434.53Ref: TM-T40187
1mg130,00€5mg311,00€10mg472,00€25mg787,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)358,00€AZ191
CAS:AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor.Fórmula:C24H27N7OPureza:98.04% - 99.65%Forma y color:SolidPeso molecular:429.52Leucettine L41
CAS:Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.Fórmula:C17H13N3O3Pureza:99.08%Forma y color:SolidPeso molecular:307.3Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Fórmula:C18H17N5O3SPureza:98%Forma y color:SolidPeso molecular:383.42ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.Fórmula:C19H17N3O3Pureza:100% - 98.85%Forma y color:SolidPeso molecular:335.36Ref: TM-T2670
2mg34,00€5mg49,00€10mg74,00€25mg142,00€50mg235,00€100mg349,00€200mg497,00€1mL*10mM (DMSO)49,00€YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Fórmula:C25H27FN8OSPureza:98.45% - 99.57%Forma y color:SolidPeso molecular:506.6ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Fórmula:C14H15NO3SPureza:97.19%Forma y color:SolidPeso molecular:277.34ML 315
CAS:ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Fórmula:C18H13Cl2N3O2Pureza:99.08%Forma y color:SolidPeso molecular:374.22GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Fórmula:C18H10Cl2N4OSPureza:98.27%Forma y color:SolidPeso molecular:401.27DYRKs-IN-1
CAS:DYRKs-IN-1 has antitumor activity.Fórmula:C30H30ClN7O4Pureza:98%Forma y color:SolidPeso molecular:588.06INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Fórmula:C12H13NO2SPureza:98.15%Forma y color:SolidPeso molecular:235.3
