HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Productos de "HSP"
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Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Fórmula:C20H20N4O3Pureza:97.29% - 99.95%Forma y color:SolidPeso molecular:364.4Ref: TM-T2309
5mg66,00€10mg87,00€25mg133,00€50mg166,00€100mg250,00€200mg424,00€500mg702,00€1mL*10mM (DMSO)74,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Fórmula:C23H38OPureza:99.76% - 99.96%Forma y color:SolidPeso molecular:330.55SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Forma y color:SolidPeso molecular:718.02Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.9% - 99.98%Forma y color:SolidPeso molecular:429.85Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Fórmula:C32H48N4O8·HClPureza:99.94%Forma y color:SolidPeso molecular:653.21JG-231
CAS:JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.Fórmula:C22H18BrCl2N3OS4Pureza:99.21%Forma y color:SolidPeso molecular:619.47DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Fórmula:C25H29N5O4SPureza:99.81%Forma y color:SolidPeso molecular:495.59Ref: TM-T9202
1mg37,00€5mg80,00€10mg126,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)88,00€HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Fórmula:C26H27ClN4O2Pureza:97.15%Forma y color:SolidPeso molecular:462.97L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Fórmula:C8H15N3O4Pureza:99.71% - 99.97%Forma y color:SolidPeso molecular:217.22Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Fórmula:C16H32O2Pureza:99.17% - 99.67%Forma y color:White Crystalline Scales SolidPeso molecular:256.42C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Fórmula:C29H28O8Forma y color:SolidPeso molecular:504.53HSP90-IN-27
CAS:HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Fórmula:C18H21N3O2SPureza:98%Forma y color:SolidPeso molecular:343.44Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Fórmula:C32H48N4O8Pureza:100%Forma y color:SolidPeso molecular:616.75NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Fórmula:C32H32FN5O4Pureza:99.26%Forma y color:SolidPeso molecular:569.63Ref: TM-T9804
1mg96,00€5mg240,00€10mg375,00€25mg627,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)300,00€Radicicol
CAS:Radicicol is an antifungal antibiotic, a inhibitor of Hsp90 & FTO, Anti-malarial , inhibits iNOS gene expression by blocking the p38 kinase and NF-κB/Rel.Fórmula:C18H17ClO6Pureza:98%Forma y color:White/Yellow PowderPeso molecular:364.78Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFórmula:C28H34O5Pureza:99.52% - 99.52%Forma y color:SolidPeso molecular:450.57Ref: TM-TN6729
1mg131,00€5mg286,00€10mg515,00€25mg777,00€50mg1.074,00€100mg1.454,00€1mL*10mM (DMSO)354,00€GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.11%Forma y color:SoildPeso molecular:342.42IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:100%Forma y color:SolidPeso molecular:545.62VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Fórmula:C19H18ClN3O4Pureza:99.36% - 99.99%Forma y color:SolidPeso molecular:387.82Ref: TM-T3454
2mg46,00€5mg64,00€10mg92,00€25mg164,00€50mg259,00€100mg354,00€200mg500,00€1mL*10mM (DMSO)52,00€Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Fórmula:C25H26N8OPureza:99.22% - 99.49%Forma y color:SolidPeso molecular:454.53NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.Fórmula:C31H35F3N2O5SPureza:98%Forma y color:SolidPeso molecular:604.68Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Fórmula:C23H28O11Pureza:96.9% - 97.16%Forma y color:White Fine PowderPeso molecular:480.46Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Fórmula:C24H18F3N5O3Forma y color:SolidPeso molecular:481.43Tanespimycin
CAS:Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Forma y color:Dark Purple SolidPeso molecular:585.69KU-177
CAS:KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Fórmula:C27H23NO8Pureza:97.34% - 98.54%Forma y color:SolidPeso molecular:489.47Calyxin H
CAS:Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.Fórmula:C35H34O7Pureza:98%Forma y color:SolidPeso molecular:566.64SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Fórmula:C22H26FN3O3Pureza:99.86%Forma y color:SolidPeso molecular:399.46Ref: TM-T28824
1mg89,00€5mg188,00€10mg316,00€25mg512,00€50mg702,00€100mg940,00€500mgA consultar1mL*10mM (DMSO)207,00€7-Aminocephalosporanic acid
CAS:7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Fórmula:C10H12N2O5SPureza:91.05% - 98.22%Forma y color:White Solid PowderPeso molecular:272.28HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Fórmula:C22H24N2O6SPureza:98%Forma y color:SolidPeso molecular:444.5DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Fórmula:C13H9BrClN5O2Pureza:100%Forma y color:SolidPeso molecular:382.6Ref: TM-T27193
1mg185,00€5mg409,00€10mg605,00€25mg938,00€50mg1.293,00€100mg1.738,00€500mg3.496,00€1mL*10mM (DMSO)406,00€TRAP1-IN-2
CAS:TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Fórmula:C46H42F6N2O5P2Pureza:98%Forma y color:SolidPeso molecular:878.77Ethoxyquin
CAS:Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:95.94%Forma y color:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecular:217.31Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Fórmula:C20H19NO4Pureza:93.77%Forma y color:SolidPeso molecular:337.37Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Fórmula:C14H20ClN3O3Pureza:99.81%Forma y color:SolidPeso molecular:313.78Ref: TM-T13553
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)249,00€AT-533
CAS:AT-533 inhibits Hsp90, HSV, hinders HIF-1α/VEGF/VEGFR-2, Erk1/2, FAK, Akt/mTOR/p70S6K, and blocks tumor growth, angiogenesis, and HUVEC activities.Fórmula:C23H30N4O3Pureza:99.54%Forma y color:SoildPeso molecular:410.51Ref: TM-T67836
1mg51,00€5mg111,00€10mg170,00€25mg313,00€50mg467,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)117,00€Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:99% - 99.28%Forma y color:SolidPeso molecular:634.61Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Fórmula:C22H28N2O2Pureza:97.02%Forma y color:SolidPeso molecular:352.47PF-04929113 Mesylate
CAS:PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37Fórmula:C26H34F3N5O7SPureza:99% - 99.46%Forma y color:SolidPeso molecular:617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€1mL*10mM (DMSO)233,00€HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Fórmula:C52H60N6O12SPureza:97.09%Forma y color:SolidPeso molecular:993.13Ref: TM-T18018
1mg90,00€5mg215,00€10mg344,00€25mg612,00€50mg848,00€100mg1.159,00€1mL*10mM (DMSO)378,00€Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Fórmula:C24H31N3O3Pureza:98.05% - 99.82%Forma y color:SolidPeso molecular:409.5217-AEP-GA
CAS:17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.Fórmula:C34H50N4O8Pureza:97.77% - 99.56%Forma y color:SolidPeso molecular:642.78Apoptozole
CAS:Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Fórmula:C33H25F6N3O3Pureza:99.75%Forma y color:SolidPeso molecular:625.56Ref: TM-T3293
2mg35,00€5mg50,00€10mg84,00€25mg137,00€50mg235,00€100mg349,00€200mg515,00€1mL*10mM (DMSO)66,00€VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Fórmula:C19H18ClN3O4Pureza:100% - 99.17%Forma y color:SolidPeso molecular:387.82Ref: TM-T2268
1mg60,00€2mg85,00€5mg111,00€10mg167,00€25mg283,00€50mg472,00€100mg643,00€1mL*10mM (DMSO)96,00€KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Fórmula:C20H25NO8Pureza:98%Forma y color:SolidPeso molecular:407.41HSP90-IN-22
CAS:HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFórmula:C25H30N4O3Pureza:98%Forma y color:SolidPeso molecular:434.53XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Fórmula:C29H37N5O3Pureza:98.1%Forma y color:SolidPeso molecular:503.64PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Fórmula:C43H50N6O7Pureza:98%Forma y color:SolidPeso molecular:762.89VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Fórmula:C25H23Cl2N7O4Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:556.4Ref: TM-T7010
2mg47,00€5mg69,00€10mg93,00€25mg163,00€50mg283,00€100mg467,00€200mg653,00€1mL*10mM (DMSO)85,00€CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Fórmula:C38H40F2N6O4Forma y color:SolidPeso molecular:682.76KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Forma y color:SolidPeso molecular:574.66Ref: TM-T6558
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg662,00€1mL*10mM (DMSO)205,00€2',4'-DIHYDROXYCHALCONE
CAS:2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effectsFórmula:C15H12O3Pureza:98.95%Forma y color:SolidPeso molecular:240.25Ref: TM-T8829
2mg42,00€5mg62,00€10mg87,00€25mg154,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)65,00€Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Fórmula:C29H31NO7Pureza:95.32% - 98.46%Forma y color:SolidPeso molecular:505.56Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Fórmula:C17H24O11Pureza:99.15%Forma y color:SolidPeso molecular:404.37Ref: TM-TQ0280
1mg85,00€5mg180,00€10mg274,00€25mg465,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)298,00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Fórmula:C18H19N5SPureza:99.13%Forma y color:SolidPeso molecular:337.44PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Fórmula:C25H30F3N5O4Pureza:99.06%Forma y color:SolidPeso molecular:521.53Ref: TM-T6341
1mg39,00€2mg49,00€5mg84,00€10mg119,00€25mg187,00€50mg354,00€100mg527,00€1mL*10mM (DMSO)96,00€HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Fórmula:C29H38O7Pureza:98%Forma y color:SolidPeso molecular:498.61HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Fórmula:C33H40N2O4Forma y color:SolidPeso molecular:528.68NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.82%Forma y color:SolidPeso molecular:454.43Ref: TM-T6609
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg310,00€100mg442,00€200mg622,00€1mL*10mM (DMSO)70,00€Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFórmula:C36H56O9Pureza:96.16%Forma y color:SolidPeso molecular:632.822-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Fórmula:C11H18O2Pureza:98%Forma y color:SolidPeso molecular:182.26Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Fórmula:C28H34O7Pureza:99.38% - 99.68%Forma y color:SolidPeso molecular:482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFórmula:C28H32N2O3SPureza:98%Forma y color:SolidPeso molecular:476.63TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Fórmula:C45H39F7N2O4P2Pureza:98%Forma y color:SolidPeso molecular:866.74HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Fórmula:C29H48O10Pureza:98%Forma y color:SolidPeso molecular:556.69KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Fórmula:C23H20ClFO4Forma y color:SolidPeso molecular:414.85PU-H71 HCl
CAS:PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Fórmula:C18H22ClIN6O2SPureza:98.95%Forma y color:SoildPeso molecular:548.83Hsp90-IN-38
CAS:Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.Fórmula:C28H35N3O5Forma y color:SolidPeso molecular:493.595TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Fórmula:C25H31N5O4Pureza:92.66%Forma y color:SolidPeso molecular:465.54Ref: TM-T3527
1mg37,00€5mg80,00€10mg111,00€25mg210,00€50mg298,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)81,00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Fórmula:C29H40N2O9Pureza:98.83% - 99.27%Forma y color:Yellow To Orange PowderPeso molecular:560.64KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Fórmula:C13H12N6O2Pureza:97.25% - 99.91%Forma y color:SolidPeso molecular:284.27Ref: TM-T3652
5mg51,00€10mg77,00€25mg159,00€50mg263,00€100mg510,00€200mg717,00€500mg1.093,00€1mL*10mM (DMSO)52,00€Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Fórmula:C46H62N4O11Pureza:99.27% - 99.8%Forma y color:Red-Violet Crystalline PowderPeso molecular:847Tasiamide B
CAS:Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Fórmula:C50H74N8O12Forma y color:SolidPeso molecular:979.17AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Fórmula:C11H18N5O12P3Pureza:98%Forma y color:SolidPeso molecular:505.212-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Fórmula:C7H8O3Forma y color:SolidPeso molecular:140.14MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Fórmula:C21H22ClN3OS2Pureza:98.2%Forma y color:SolidPeso molecular:432BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.763-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:98.84%Forma y color:SolidPeso molecular:269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Forma y color:SolidPeso molecular:415.9TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Fórmula:C25H32ClN5O4Pureza:97.55%Forma y color:SolidPeso molecular:502.01AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Fórmula:C11H16N5Na2O12P3Pureza:100%Forma y color:SolidPeso molecular:549.17VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Fórmula:C21H23Cl2N5O2SPureza:98% - 99.16%Forma y color:SolidPeso molecular:480.41HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.58KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Fórmula:C18H13Cl2F3N2O2Pureza:97.36%Forma y color:SolidPeso molecular:417.21Ref: TM-T72076
1mg78,00€5mg190,00€10mg284,00€25mg505,00€50mg677,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)215,00€CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.51%Forma y color:SolidPeso molecular:469.94Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:SolidPeso molecular:442.58NCT-58
CAS:NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Fórmula:C27H34N2O5Pureza:98.75%Forma y color:SolidPeso molecular:466.57Ref: TM-T9996
2mg46,00€5mg85,00€10mg126,00€25mg259,00€50mg415,00€100mg662,00€200mg889,00€1mL*10mM (DMSO)207,00€Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Fórmula:C26H31N3O5Pureza:98% - 99.26%Forma y color:SolidPeso molecular:465.54Ref: TM-T1989
5mg57,00€10mg81,00€25mg145,00€50mg221,00€100mg363,00€200mg540,00€500mg872,00€1mL*10mM (DMSO)63,00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Fórmula:C21H19N3O2S2Pureza:98.89%Forma y color:SolidPeso molecular:409.52Ref: TM-T4125
1mg55,00€2mg88,00€5mg139,00€10mg207,00€25mg462,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)130,00€Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFórmula:C31H30N6O6S4Pureza:98%Forma y color:Off-White To Fawn SolidPeso molecular:710.87SNX2112
CAS:SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Fórmula:C23H27F3N4O3Pureza:98.9% - 99.46%Forma y color:SolidPeso molecular:464.48Ref: TM-T6305
1mg40,00€5mg85,00€10mg127,00€25mg220,00€50mg334,00€100mg477,00€200mg662,00€1mL*10mM (DMSO)87,00€CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Forma y color:SolidPeso molecular:552.62Ref: TM-T14905
1mg39,00€5mg116,00€10mg221,00€25mg457,00€50mg733,00€100mg1.111,00€200mg1.501,00€1mL*10mM (DMSO)144,00€HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFórmula:C13H12O4SPureza:99.51%Forma y color:SolidPeso molecular:264.3Ref: TM-T7265
1mg130,00€2mg185,00€5mg311,00€10mg472,00€25mg753,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)455,00€HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Fórmula:C24H28N6O2SPureza:100%Forma y color:SolidPeso molecular:464.58Ref: TM-T3487
1mg96,00€5mg227,00€10mg354,00€25mg620,00€50mg847,00€100mg1.169,00€1mL*10mM (DMSO)230,00€Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:98.67% - 99.03%Forma y color:SolidPeso molecular:257.24Ref: TM-T10860
2mg47,00€5mg70,00€10mg107,00€25mg216,00€50mg350,00€100mg542,00€200mg778,00€500mg1.169,00€1mL*10mM (DMSO)70,00€Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Fórmula:C24H30O9Pureza:98.18% - 99.22%Forma y color:SolidPeso molecular:462.49NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Fórmula:C20H18FN5O2Pureza:97.63% - 99.32%Forma y color:SolidPeso molecular:379.39BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Fórmula:C21H24N4O4SPureza:98%Forma y color:SolidPeso molecular:428.51EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Fórmula:C21H24ClN5O2Forma y color:SolidPeso molecular:413.9YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Fórmula:C21H19ClN2O4Pureza:97.25%Forma y color:SolidPeso molecular:398.84Ref: TM-T8901
1mg48,00€5mg96,00€10mg135,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)96,00€
