NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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NLRP3 agonist 1
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Fórmula:C15H16N6Pureza:99.01%Forma y color:SolidPeso molecular:280.33Salicortin
CAS:Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.Fórmula:C20H24O10Pureza:98%Forma y color:SolidPeso molecular:424.40GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Fórmula:C28H30N4O3Pureza:99.32%Forma y color:SolidPeso molecular:470.56BEC hydrochloride
CAS:BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.Fórmula:C5H12BNO4S·ClHPureza:98.65% - 99.28%Forma y color:SolidPeso molecular:229.49Ref: TM-T6779
1mg39,00€2mg49,00€5mg88,00€10mg153,00€25mg283,00€50mg535,00€100mg747,00€1mL*10mM (DMSO)88,00€Sanggenon A
CAS:Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFórmula:C25H24O7Pureza:98%Forma y color:SolidPeso molecular:436.45Narlumosbart
CAS:Narlumosbart (JMT103) is an IgG4κ monoclonal antibody that selectively binds to the receptor activator of nuclear factor-κB ligand (RANKL)[1].Pureza:98%Forma y color:LiquidRIPK1-IN-19
CAS:RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Fórmula:C28H25FN6O2Pureza:98.81%Forma y color:SolidPeso molecular:496.54PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Fórmula:C22H24N4O3SPureza:98.09% - 98.13%Forma y color:SolidPeso molecular:424.52Ref: TM-T12493
1mg86,00€5mg170,00€10mg274,00€25mg520,00€50mg750,00€100mg1.026,00€200mg1.388,00€1mL*10mM (DMSO)188,00€IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFórmula:C35H33N5O2Pureza:98%Forma y color:SolidPeso molecular:555.67(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Fórmula:C27H30F3N9OPureza:98%Forma y color:SolidPeso molecular:553.58DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Fórmula:C23H20N2O2Pureza:99.34%Forma y color:SolidPeso molecular:356.42Ref: TM-T10981
1mg52,00€5mg116,00€10mg188,00€25mg354,00€50mg588,00€100mg873,00€1mL*10mM (DMSO)126,00€Kukoamine A
CAS:Kukoamine A: anticancer, cytoprotective, antioxidant, anti-inflammatory, inhibits trypanothione reductase (mixed inhibitor, Ki=1.8µM).Fórmula:C28H42N4O6Pureza:97.45% - 99.28%Forma y color:SolidPeso molecular:530.66Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:99.13%Forma y color:SolidPeso molecular:767IRAK4-IN-1
CAS:IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.Fórmula:C19H23N5OPureza:98.18% - 99.74%Forma y color:SolidPeso molecular:337.42Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.Fórmula:C15H24O5Pureza:99.41% - 99.72%Forma y color:White SolidPeso molecular:284.35Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Forma y color:White Solid CrystallinePeso molecular:180.16IRAK4-IN-7
CAS:IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.Fórmula:C21H19N7O3Pureza:99.50%Forma y color:SolidPeso molecular:417.42Ref: TM-T5354
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg210,00€50mg354,00€100mg528,00€1mL*10mM (DMSO)87,00€Ginsenoside Rg1
CAS:Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Fórmula:C42H72O14Pureza:99% - 99.74%Forma y color:White Crystalline PowderPeso molecular:801.01Vamorolone
CAS:Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Fórmula:C22H28O4Pureza:99.54%Forma y color:SolidPeso molecular:356.46Ref: TM-T17217
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg188,00€50mg298,00€100mg444,00€200mg640,00€1mL*10mM (DMSO)87,00€Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Fórmula:C17H16O4Pureza:98.31% - ≥95%Forma y color:SolidPeso molecular:284.31Supercinnamaldehyde
CAS:Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ionFórmula:C12H11NO2Pureza:98.89%Forma y color:SolidPeso molecular:201.22Stachydrine
CAS:Stachydrine, found in leonurus herb, aids blood flow, blocks NF-κB pathway, and indicates citrus intake.Fórmula:C7H13NO2Pureza:≥95%Forma y color:SolidPeso molecular:143.18OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Fórmula:C44H70O16Pureza:99.46% - ≥95%Forma y color:SolidPeso molecular:855.02Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Fórmula:C17H22O5Pureza:99.64%Forma y color:SolidPeso molecular:306.35Ref: TM-T13686
1mg74,00€5mg146,00€10mg243,00€25mg394,00€50mg548,00€100mg735,00€1mL*10mM (DMSO)170,00€Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Forma y color:SolidPeso molecular:383.82IRAK inhibitor 1
CAS:IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).Fórmula:C17H19N5Pureza:100% - 97.78%Forma y color:SolidPeso molecular:293.37Ref: TM-T5094
1mg95,00€2mg125,00€5mg202,00€10mg283,00€25mg472,00€50mg687,00€100mg938,00€1mL*10mM (DMSO)135,00€Erdosteine
CAS:Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Fórmula:C8H11NO4S2Pureza:99.43% - 99.94%Forma y color:White Or Almost White Crystalline PowderPeso molecular:249.31CTP-NBD
CAS:CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Fórmula:C121H194N46O32Pureza:98%Forma y color:SolidPeso molecular:2805.12Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Fórmula:C36H56O8Pureza:100% - 99.5%Forma y color:White To Off-White SolidPeso molecular:616.83Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Forma y color:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Muramyl dipeptide
CAS:MDP is a synthetic peptide promoting bone formation by modulating osteoclasts, osteoblasts, and Runx2 expression via MAPK pathways.Fórmula:C19H32N4O11Pureza:100%Forma y color:SolidPeso molecular:492.48Ref: TM-T16159
1mg88,00€5mg178,00€10mg279,00€25mg545,00€50mg777,00€100mg1.064,00€200mg1.415,00€1mL*10mM (DMSO)188,00€Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Fórmula:C13H15NO2SPureza:99.76% - 99.83%Forma y color:White SolidPeso molecular:249.33Ref: TM-T1934
2mg35,00€5mg50,00€10mg66,00€25mg85,00€50mg124,00€100mg197,00€200mg255,00€1mL*10mM (DMSO)62,00€Andrographolide
CAS:Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFórmula:C20H30O5Pureza:100% - 99.97%Forma y color:PowderPeso molecular:350.45Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Forma y color:SolidPeso molecular:413.28Ref: TM-T6027
1mg46,00€5mg96,00€10mg140,00€25mg274,00€50mg439,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)95,00€IRAK4-IN-4
CAS:IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4)Fórmula:C22H16N2O2Pureza:99.52%Forma y color:SolidPeso molecular:340.37Ref: TM-T11673
1mg64,00€5mg145,00€10mg212,00€25mg378,00€50mg567,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)160,00€Demethyleneberberine chloride
CAS:Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Fórmula:C19H18ClNO4Pureza:98%Forma y color:SolidPeso molecular:359.8RIPK1-IN-4
CAS:RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50sFórmula:C23H23N5O2Pureza:99.66%Forma y color:SolidPeso molecular:401.46DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Fórmula:C17H27NO3Pureza:100.00%Forma y color:SolidPeso molecular:293.4Triptolide
CAS:Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.Fórmula:C20H24O6Pureza:97.19% - 99.97%Forma y color:White To Off-White SolidPeso molecular:360.4Ref: TM-T2179
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg310,00€50mg462,00€100mg553,00€1mL*10mM (DMSO)85,00€Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Fórmula:C27H45NO2Pureza:98.38% - 99.98%Forma y color:SolidPeso molecular:415.65EN450
CAS:EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.Fórmula:C11H13ClN2O3SPureza:99.72%Forma y color:SoildPeso molecular:288.75Ref: TM-T77525
1mg47,00€5mg87,00€10mg144,00€25mg283,00€50mg432,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)97,00€Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Forma y color:SolidPeso molecular:288.82Anti-inflammatory agent 60
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-cateninPureza:98%Forma y color:Odour SolidGSK872 HCl(1346546-69-7 free base)
CAS:GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor.Fórmula:C19H18ClN3O2S2Pureza:99%Forma y color:SolidPeso molecular:419.94Pristimerin
CAS:Pristimerin has anticancer properties, counters hypoxia-induced cancer spread, and reduces inflammation by inhibiting ROS/IKK/NF-κB pathways.Fórmula:C30H40O4Pureza:99.43% - 99.59%Forma y color:SolidPeso molecular:464.64(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFórmula:C22H23NOPureza:98.55%Forma y color:SolidPeso molecular:317.42Ref: TM-T11139
1mg80,00€5mg155,00€10mg283,00€25mg452,00€50mg638,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)170,00€RIP1 kinase inhibitor 6
CAS:RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1Fórmula:C19H18F2N2O3Pureza:98%Forma y color:SolidPeso molecular:360.35TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Forma y color:SolidPeso molecular:457.52Ref: TM-T15559
1mg92,00€5mg188,00€10mg305,00€25mg487,00€50mg660,00€100mg847,00€1mL*10mM (DMSO)188,00€TAK-243
CAS:TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).Fórmula:C19H20F3N5O5S2Pureza:98.09% - 98.93%Forma y color:SolidPeso molecular:519.52Ref: TM-T16974
1mg48,00€2mg64,00€5mg96,00€10mg150,00€25mg268,00€50mg459,00€100mg658,00€1mL*10mM (DMSO)107,00€SBI-0640726
CAS:SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.Fórmula:C23H15ClN2O2Forma y color:SolidPeso molecular:386.83
