NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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JSH-23
CAS:JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.Fórmula:C16H20N2Pureza:98.03% - 99.67%Forma y color:SolidPeso molecular:240.34Ref: TM-T1930
1mg43,00€2mg57,00€5mg93,00€10mg119,00€25mg187,00€50mg283,00€100mg430,00€1mL*10mM (DMSO)93,00€Quinoclamine
CAS:Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.Fórmula:C10H6ClNO2Pureza:99.13% - 99.28%Forma y color:Orange PowderPeso molecular:207.617,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Forma y color:SolidPeso molecular:254.24Emlenoflast sodium
CAS:Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome,Fórmula:C19H24N4NaO3SForma y color:SolidPeso molecular:411.47SjDX5-271
CAS:SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Fórmula:C137H215N47O49SForma y color:SolidPeso molecular:3336.52NF-κΒ activator 2
CAS:NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.Fórmula:C16H11FN2O3Pureza:99.32%Forma y color:SolidPeso molecular:298.27Ref: TM-T39924
1mg94,00€2mg136,00€5mg226,00€10mg335,00€25mg538,00€50mg730,00€100mg938,00€1mL*10mM (DMSO)249,00€HS-1371
CAS:HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.Fórmula:C24H24N4OPureza:98%Forma y color:SolidPeso molecular:384.47Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Fórmula:C6H9NOS2Pureza:98.01% - 99.19%Forma y color:Slightly Yellowish LiquidPeso molecular:175.27Ref: TM-TL0016
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)69,00€Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).Fórmula:C141H210N32O44SPureza:98%Forma y color:SolidPeso molecular:3089.43CORM-3
CAS:CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.Fórmula:C5H4ClNO5RuPureza:98%Forma y color:SolidPeso molecular:294.61NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Forma y color:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€Indacaterol
CAS:Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.Fórmula:C24H28N2O3Pureza:100.00% - 99.63%Forma y color:SolidPeso molecular:392.49Sulfuretin
CAS:Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.Fórmula:C15H10O5Pureza:100% - 98.91%Forma y color:SolidPeso molecular:270.24WITHAFERIN A
CAS:WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Fórmula:C28H38O6Pureza:97.41% - 99.83%Forma y color:SolidPeso molecular:470.6Ref: TM-T5687
1mg85,00€5mg265,00€10mg393,00€25mg653,00€50mg929,00€100mg1.254,00€500mg2.517,00€1mL*10mM (DMSO)304,00€IRAK4-IN-28
CAS:IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.Fórmula:C27H31N9O3Pureza:98%Forma y color:SolidPeso molecular:529.59Isonardosinone
CAS:Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities.Fórmula:C15H22O3Pureza:98%Forma y color:SolidPeso molecular:250.33GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Fórmula:C17H17BrF3N7O2SPureza:99.46% - ≥98%Forma y color:SolidPeso molecular:520.33Ref: TM-T5540
1mg47,00€2mg59,00€5mg92,00€10mg131,00€25mg215,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)96,00€Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Fórmula:C42H72O13Pureza:99.5% - 99.77%Forma y color:SolidPeso molecular:785.01Ref: TM-T2873
2mg37,00€5mg52,00€10mg88,00€25mg131,00€50mg188,00€100mg279,00€500mg658,00€1mL*10mM (DMSO)87,00€Pratensein
CAS:Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Fórmula:C16H12O6Pureza:99.72%Forma y color:SolidPeso molecular:300.26γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€Tyrosol
CAS:Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present mostFórmula:C8H10O2Pureza:100% - 99.28%Forma y color:SolidPeso molecular:138.16Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Fórmula:C40H52O4Pureza:95.1% - 99.79%Forma y color:Needles From Acetone/Light Petroleum SolidPeso molecular:596.84TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Fórmula:C17H17NOPureza:99.65%Forma y color:SolidPeso molecular:251.32Handelin
CAS:Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.Fórmula:C32H40O8Pureza:99.02%Forma y color:SolidPeso molecular:552.66RIPK2-IN-3
CAS:RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.Fórmula:C25H22N4O2Pureza:99.57%Forma y color:SolidPeso molecular:410.47GSK2983559 free acid
CAS:GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.Fórmula:C21H23N4O7PS2Pureza:97.87% - 98.61%Forma y color:SolidPeso molecular:538.53Narasin (sodium salt)
CAS:Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells andFórmula:C43H71NaO11Pureza:98%Forma y color:SolidPeso molecular:787.01Oditrasertib
CAS:Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Fórmula:C14H15F2N3O2Pureza:98.65% - 99.65%Forma y color:SolidPeso molecular:295.28Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Fórmula:C27H34O14Pureza:99.07% - 99.16%Forma y color:Solid PowderPeso molecular:582.55Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Fórmula:C19H20O6Pureza:99.88%Forma y color:SolidPeso molecular:344.36NIK SMI1
CAS:NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Fórmula:C20H19N3O4Pureza:99.04% - 99.99%Forma y color:SolidPeso molecular:365.38Ref: TM-T16290
1mg87,00€5mg183,00€10mg296,00€25mg593,00€50mg932,00€100mg1.501,00€200mg2.052,00€1mL*10mM (DMSO)432,00€NDMC101
CAS:NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Fórmula:C13H9ClFNO2Pureza:99.89%Forma y color:SolidPeso molecular:265.67MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Fórmula:C26H36N6O2Pureza:99.25% - 99.79%Forma y color:SolidPeso molecular:464.6GSK481
CAS:GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.Fórmula:C21H19N3O4Pureza:98.97%Forma y color:SolidPeso molecular:377.39COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Forma y color:Odour SolidCOX-2-IN-32
CAS:COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Fórmula:C25H24O6Pureza:98%Forma y color:SolidPeso molecular:420.45Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Fórmula:C5H6N2OSPureza:100% - 99.89%Forma y color:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18α-Lipoic Acid
CAS:α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Fórmula:C8H14O2S2Pureza:98.39% - 99.73%Forma y color:Forms Yellowish Flakes Light Yellow To Yellow PowderPeso molecular:206.33Shikonin
CAS:Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Fórmula:C16H16O5Pureza:98.13% - 99.9%Forma y color:SolidPeso molecular:288.3Ref: TM-T1125
5mg34,00€10mg52,00€25mg87,00€50mg140,00€100mg215,00€200mg319,00€500mg533,00€1mL*10mM (DMSO)52,00€20(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Fórmula:C42H72O13Pureza:100% - 99.93%Forma y color:SolidPeso molecular:785.01UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Fórmula:C18H17N3OPureza:99.48%Forma y color:SolidPeso molecular:291.35Ref: TM-T88314
2mg38,00€5mg57,00€10mg92,00€25mg166,00€50mg254,00€100mg389,00€200mg566,00€1mL*10mM (DMSO)63,00€ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Fórmula:C32H22O10Pureza:98% - 99.72%Forma y color:SolidPeso molecular:566.51Denosumab
CAS:Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligandFórmula:C6404H9912N1724O2004S50Pureza:98.4% (SEC-HPLC) - 99.90%Forma y color:LiquidPeso molecular:144.71 kDaTrovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.12%Forma y color:SolidPeso molecular:512.46Selinidin
CAS:Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Fórmula:C19H20O5Pureza:98%Forma y color:SolidPeso molecular:328.364Biricodar dicitrate
CAS:Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.Fórmula:C46H57N3O21Pureza:98.67% - 99.34%Forma y color:SolidPeso molecular:987.95Ginsenoside Rg6
CAS:Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFórmula:C42H70O12Pureza:≥98%Forma y color:SolidPeso molecular:767Obtusifolin
CAS:Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Fórmula:C16H12O5Pureza:100% - 99.79%Forma y color:SolidPeso molecular:284.26Ref: TM-T4S0969
1mg70,00€5mg187,00€10mg279,00€25mg472,00€50mg658,00€100mg933,00€1mL*10mM (DMSO)187,00€Molsidomine
CAS:Molsidomine, an oral vasodilator, turns into linsidomine in the liver, releasing NO for prolonged effects.Fórmula:C9H14N4O4Pureza:100% - 99.98%Forma y color:Colorless Or White Crystalline PowderPeso molecular:242.23Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Fórmula:C13H21ClN2O3SPureza:99.76%Forma y color:White Crystalline PowderPeso molecular:320.84
