NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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4-Aminosalicylic acid
CAS:4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Fórmula:C7H7NO3Pureza:97.07%Forma y color:Minute Crystals From Alc SolidPeso molecular:153.14IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Fórmula:C14H10N4O3Pureza:99.67%Forma y color:SolidPeso molecular:282.25BMS986299
CAS:BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Fórmula:C18H19N7OPureza:99.93% - 99.93%Forma y color:SolidPeso molecular:349.39Esculentoside A
CAS:Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Fórmula:C42H66O16Pureza:98% - 99.85%Forma y color:SolidPeso molecular:826.96Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Fórmula:C17H20O5Pureza:98.2% - 98.96%Forma y color:SolidPeso molecular:304.34Ref: TM-T3S1707
1mg104,00€2mg145,00€5mg227,00€10mg338,00€25mg558,00€50mg797,00€100mg1.074,00€1mL*10mM (DMSO)246,00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFórmula:C26H30N2O4Pureza:98%Forma y color:SolidPeso molecular:434.53DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Fórmula:C13H11NO5Pureza:98%Forma y color:SolidPeso molecular:261.23NLRP3-IN-13
CAS:NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Fórmula:C19H15N3O3SPureza:98.82%Forma y color:SolidPeso molecular:365.41E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Fórmula:C21H30O6Pureza:98.83%Forma y color:SolidPeso molecular:378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Fórmula:C36H60O8Pureza:99.33% - 99.88%Forma y color:SolidPeso molecular:620.86Ref: TM-T6S1495
1mg85,00€5mg172,00€10mg255,00€25mg426,00€50mg630,00€100mg898,00€1mL*10mM (DMSO)283,00€IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Fórmula:C69H90F3N13O24Pureza:98%Forma y color:SoildPeso molecular:1542.54Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Fórmula:C20H20O6Pureza:100%Forma y color:SolidPeso molecular:356.37Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFórmula:C21H23N3O3Pureza:99.48%Forma y color:SolidPeso molecular:365.43Flizasertib
CAS:Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Fórmula:C15H14FN3OPureza:100% - 99.39%Forma y color:SolidPeso molecular:271.29Adelmidrol
CAS:Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Fórmula:C13H26N2O4Pureza:99.35% - 99.73%Forma y color:SolidPeso molecular:274.36Eudebeiolide B
CAS:Eudebeiolide B, isolated from Salvia plebeia R.Fórmula:C15H18O4Pureza:98%Forma y color:SolidPeso molecular:262.3Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Forma y color:SolidPeso molecular:265.25BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFórmula:C15H15NO2SPureza:99.73%Forma y color:SolidPeso molecular:273.35Ref: TM-T8705
1mg52,00€5mg116,00€10mg178,00€25mg340,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)107,00€BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Fórmula:C19H21N7O2Pureza:98%Forma y color:SolidPeso molecular:379.42Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Fórmula:C33H40O19Pureza:98.78% - 99.13%Forma y color:SolidPeso molecular:740.66IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Fórmula:C35H33N5O3Pureza:98%Forma y color:SolidPeso molecular:571.67Usnoflast
CAS:Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.Fórmula:C21H29N3O3SPureza:98.79%Forma y color:SolidPeso molecular:403.54AP-1/NF-κB activation inhibitor 1
CAS:AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basalFórmula:C13H11F3N4O4Pureza:100% - 99.74%Forma y color:SolidPeso molecular:344.25Ref: TM-T9656
1mg73,00€2mg96,00€5mg160,00€10mg216,00€25mg354,00€50mg525,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)170,00€Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Fórmula:C31H42N2O3Pureza:100% - 98.69%Forma y color:SolidPeso molecular:490.68Ref: TM-T15198
1mg99,00€2mg144,00€5mg235,00€10mg376,00€25mg677,00€50mg1.064,00€1mL*10mM (DMSO)254,00€HS271
CAS:HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Fórmula:C21H24F3N5O2Pureza:98.12%Forma y color:SolidPeso molecular:435.44Ref: TM-T37082
1mg62,00€2mg89,00€5mg135,00€10mg212,00€25mg368,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)149,00€5-Aminosalicylic Acid
CAS:5-ASA, an anti-inflammatory salicylate, treats inflammatory bowel disease, active part of sulphalazine.Fórmula:C7H7NO3Pureza:98.88% - 99.98%Forma y color:Purplish-Tan Solid PowderPeso molecular:153.14Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Fórmula:C24H30O14Pureza:100% - 99.57%Forma y color:SolidPeso molecular:542.49Ref: TM-T4S2326
1mg96,00€5mg264,00€10mg415,00€25mg677,00€50mg935,00€100mg1.254,00€500mg2.527,00€1mL*10mM (DMSO)315,00€Ref: TM-T5S0754
5mg49,00€10mg65,00€25mg97,00€50mg153,00€100mg221,00€200mg329,00€1mL*10mM (DMSO)50,00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Fórmula:C26H30O13Pureza:98.84% - 99.27%Forma y color:SolidPeso molecular:550.51Tyloxapol
CAS:Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Fórmula:C70H124O13Pureza:polymer - polymerForma y color:Clear Light Yellow Viscous LiquidPeso molecular:137.18Ref: TM-T6S1371
1mg52,00€5mg97,00€10mg140,00€25mg274,00€50mg411,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)105,00€Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFórmula:C19H18NO4Pureza:98.08% - 99.18%Forma y color:SolidPeso molecular:324.35Theaflavin 3,3'-digallate
CAS:Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.7Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Fórmula:C25H25N5O4Forma y color:SolidPeso molecular:459.50Eclitasertib
CAS:Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Fórmula:C19H18N6O3Pureza:99.82%Forma y color:SolidPeso molecular:378.38Ref: TM-T9702
1mg106,00€2mg150,00€5mg227,00€10mg359,00€25mg652,00€50mg905,00€100mg1.293,00€1mL*10mM (DMSO)250,00€BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Fórmula:C23H26IN7O2SPureza:98% - 99.57%Forma y color:SolidPeso molecular:591.47Ref: TM-T1830
5mg59,00€10mg97,00€25mg210,00€50mg343,00€100mg513,00€200mg740,00€500mg1.121,00€1mL*10mM (DMSO)88,00€CL075
CAS:CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFórmula:C13H13N3SPureza:99.25%Forma y color:SolidPeso molecular:243.33Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Fórmula:C36H49NO12Pureza:98% - 99.84%Forma y color:SolidPeso molecular:687.77Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:97.53% - 98.63%Forma y color:SolidPeso molecular:450.39Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:100% - 99.78%Forma y color:White PowderPeso molecular:947.15B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Fórmula:C19H16ClN5OSPureza:99.74%Forma y color:SolidPeso molecular:397.88Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Forma y color:SolidRIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Fórmula:C26H25FN6O2Pureza:98.7%Forma y color:SolidPeso molecular:472.51Ref: TM-T63055
1mg205,00€5mg495,00€10mg677,00€25mg1.008,00€50mg1.349,00€100mg1.833,00€200mg2.452,00€1mL*10mM (DMSO)568,00€Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Fórmula:C21H20O13Pureza:97.57% - 98.97%Forma y color:SolidPeso molecular:480.38NLRP3-IN-10
CAS:NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Fórmula:C17H14BrFO3Pureza:99.63%Forma y color:SolidPeso molecular:365.19Ref: TM-T61392
5mg47,00€10mg70,00€25mg126,00€50mg187,00€100mg311,00€200mg465,00€1mL*10mM (DMSO)65,00€2,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFórmula:C4H6N4OPureza:99.82%Forma y color:White Solid CrystalsPeso molecular:126.12NLRP3-IN-11
CAS:NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Fórmula:C17H17ClN4O2Pureza:100%Forma y color:SolidPeso molecular:344.8GSK2983559 active metabolite
CAS:GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Fórmula:C21H22N4O4S2Pureza:97.07% - 98.48%Forma y color:SolidPeso molecular:458.55Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27%Forma y color:Prisms From Methanol + Ether SolidPeso molecular:550.64
