Pim
Las quinasas Pim son una familia de quinasas serina/treonina que juegan un papel clave en la supervivencia celular, la proliferación y la apoptosis. Estas quinasas son efectores aguas abajo en la vía de señalización JAK/STAT y están involucradas en varios procesos fisiológicos, incluidas las respuestas inmunitarias y la hematopoyesis. La sobreexpresión de las quinasas Pim se ha asociado con el desarrollo de cáncer, lo que las convierte en objetivos importantes para la intervención terapéutica. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de quinasas Pim de alta calidad para apoyar su investigación en oncología, biología celular y transducción de señales.
Productos de "Pim"
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Hay 30 productos en esta categoría.
Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Fórmula:C22H13Cl2N3OPureza:98%Forma y color:SolidPeso molecular:406.26TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:97.72% - 99.95%Forma y color:SolidPeso molecular:418.46PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Fórmula:C25H30N8O2Pureza:98%Forma y color:SolidPeso molecular:474.56HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.Fórmula:C15H15N5O2SPureza:95.04%Forma y color:SolidPeso molecular:329.38Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.81%Forma y color:SoildPeso molecular:275.3Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Forma y color:Odour SolidSMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Forma y color:SolidPeso molecular:263.31Ref: TM-T3989
1mg35,00€2mg48,00€5mg70,00€10mg87,00€25mg160,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)92,00€TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Fórmula:C18H11BrN2O2Pureza:97% - 99.64%Forma y color:SolidPeso molecular:367.2Ref: TM-T2253
1mg35,00€5mg64,00€10mg88,00€25mg187,00€50mg284,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)97,00€TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Fórmula:C11H6F3NO2SPureza:99.89%Forma y color:SolidPeso molecular:273.23PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Fórmula:C27H25BrCl2CuN6OPureza:98%Forma y color:SolidPeso molecular:663.88PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Fórmula:C19H22N4O2Pureza:98%Forma y color:SolidPeso molecular:338.4AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Forma y color:SolidPeso molecular:379.48Ref: TM-T2300
2mg38,00€5mg51,00€10mg74,00€25mg118,00€50mg213,00€100mg378,00€200mg495,00€500mg792,00€1mL*10mM (DMSO)57,00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Fórmula:C17H11ClN4OPureza:98.81%Forma y color:SolidPeso molecular:322.75GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Fórmula:C22H24N8OPureza:98%Forma y color:SolidPeso molecular:416.48AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Fórmula:C18H23N3O3SPureza:99.49%Forma y color:SolidPeso molecular:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Fórmula:C22H28ClN5O3Pureza:98.30%Forma y color:SolidPeso molecular:445.94HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:99.55%Forma y color:SolidPeso molecular:225.24Ref: TM-T9583
1mg35,00€5mg80,00€10mg116,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)77,00€Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.89%Forma y color:SolidPeso molecular:235.26SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Fórmula:C20H22F3N5OPureza:100% - 99.84%Forma y color:SolidPeso molecular:405.42GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Fórmula:C20H22F3N7OSForma y color:SolidPeso molecular:465.5Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Fórmula:C16H12O6Pureza:97.54% - 98.53%Forma y color:SolidPeso molecular:300.26Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.84% - 98.69%Forma y color:SolidPeso molecular:339.35Ref: TM-T5093
1mg89,00€2mg131,00€5mg183,00€10mg278,00€25mg490,00€50mg710,00€100mg998,00€1mL*10mM (DMSO)202,00€CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Fórmula:C26H24ClN3O3Pureza:95.88%Forma y color:SolidPeso molecular:461.94Ref: TM-T1834
1mg37,00€5mg80,00€10mg106,00€25mg208,00€50mg311,00€100mg472,00€200mg658,00€1mL*10mM (DMSO)81,00€Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.76%Forma y color:SolidPeso molecular:318.24Ref: TM-T8114
1mg88,00€5mg202,00€10mg303,00€25mg510,00€50mg733,00€100mg998,00€500mg1.985,00€1mL*10mM (DMSO)213,00€(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Fórmula:C13H24O5Forma y color:SolidPeso molecular:260.33(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.44%Forma y color:SolidPeso molecular:273.23K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Fórmula:C18H18N4OPureza:97.88%Forma y color:SolidPeso molecular:306.36Ref: TM-T27704
1mg185,00€2mg279,00€5mg426,00€10mg627,00€25mg938,00€50mg1.320,00€100mg1.786,00€500mg3.591,00€1mL*10mM (DMSO)415,00€VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Fórmula:C27H27N3O3Peso molecular:441.522Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.85%Forma y color:SolidPeso molecular:611.51FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Fórmula:C21H20F2N4O2SPureza:98%Forma y color:SolidPeso molecular:430.47
