MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Productos de "MAPK"
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CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Fórmula:C8H9Cl2NO3Pureza:98.1%Forma y color:SoildPeso molecular:238.07Ref: TM-T10809L
1mg56,00€5mg116,00€10mg168,00€25mg269,00€50mg383,00€100mg510,00€200mg692,00€1mL*10mM (DMSO)101,00€SB 202190 hydrochloride
CAS:SB 202190 hydrochloride is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor ,differentiation to cardiomyocytes.Fórmula:C20H15ClFN3OPureza:99.99%Forma y color:SolidPeso molecular:367.8Ref: TM-T35592
2mg49,00€5mg66,00€10mg90,00€25mg145,00€50mg207,00€100mg309,00€200mg459,00€1mL*10mM (DMSO)71,00€Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Forma y color:SolidPeso molecular:430.46Lupalbigenin
CAS:Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.Fórmula:C25H26O5Pureza:98%Forma y color:SolidPeso molecular:406.47Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 98.60%Forma y color:SolidPeso molecular:462.89ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.77%Forma y color:SoildPeso molecular:337.8Ref: TM-T77734
1mg86,00€2mg111,00€5mg180,00€10mg279,00€25mg562,00€50mg917,00€100mg1.454,00€500mg2.822,00€Farrerol
CAS:Farrerol shows antioxidative effects, modulates genes, fights S. aureus in cows, protects cells, and may prevent heart disease.Fórmula:C17H16O5Pureza:99.89% - 99.96%Forma y color:SolidPeso molecular:300.31Ref: TM-T6S0525
2mg43,00€5mg59,00€10mg85,00€25mg120,00€50mg170,00€100mg253,00€200mg375,00€1mL*10mM (DMSO)71,00€B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Fórmula:C20H19N5O3SPureza:98.59% - 99.56%Forma y color:SolidPeso molecular:409.46Gardenin A
CAS:Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.Fórmula:C21H22O9Pureza:95.15% - 95.15%Forma y color:SolidPeso molecular:418.39Ref: TM-TN4114
1mg187,00€5mg467,00€10mg693,00€25mg1.074,00€50mg1.454,00€100mg1.882,00€500mg3.924,00€1mL*10mM (DMSO)502,00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24Ref: TM-T8870
1mg51,00€5mg153,00€10mg207,00€25mg288,00€50mg404,00€100mg562,00€200mg758,00€1mL*10mM (DMSO)101,00€p38-α MAPK-IN-10
CAS:p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.Fórmula:C27H34Cl2N6Forma y color:SolidPeso molecular:513.505Corylifol C
CAS:Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factorFórmula:C20H18O5Pureza:98%Forma y color:SolidPeso molecular:338.35SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Forma y color:SolidPeso molecular:541.61JWG-071
CAS:JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Fórmula:C34H44N8O3Pureza:98.33%Forma y color:SolidPeso molecular:612.77Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Forma y color:SolidPeso molecular:425.91Ref: TM-T9407
1mg40,00€5mg80,00€10mg116,00€25mg205,00€50mg340,00€100mg485,00€200mg655,00€1mL*10mM (DMSO)88,00€DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:SolidPeso molecular:321.33Laxiflorin B-4
Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].Pureza:98%Forma y color:Odour SolidPS-166276
CAS:PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Fórmula:C20H30N8OForma y color:SolidPeso molecular:398.51NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Fórmula:C21H21N5O2Pureza:97.04% - 99.46%Forma y color:SolidPeso molecular:375.42LJI308
CAS:LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Fórmula:C21H18F2N2O2Pureza:98.86% - 99.73%Forma y color:SolidPeso molecular:368.38
