Ras
Las proteínas Ras son pequeñas GTPasas que actúan como interruptores moleculares en la vía de señalización MAPK, controlando el crecimiento, la diferenciación y la supervivencia celular. Ras activado inicia una cascada de señalización que incluye Raf, MEK y ERK, lo que lleva a diversas respuestas celulares. Las mutaciones en los genes Ras son comunes en el cáncer, lo que convierte a Ras en un enfoque importante de la investigación oncológica. En CymitQuimica, ofrecemos una gama de moduladores de Ras para apoyar su investigación en biología del cáncer, transducción de señales y desarrollo terapéutico.
Productos de "Ras"
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ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Fórmula:C21H17ClF2N4O2Pureza:98.88%Forma y color:SolidPeso molecular:430.84FTI-277 hydrochloride
CAS:FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Fórmula:C22H30ClN3O3S2Pureza:97.57% - 97.61%Forma y color:SolidPeso molecular:484.07Ref: TM-T2700
1mg52,00€2mg73,00€5mg96,00€10mg175,00€25mg320,00€50mg537,00€100mg753,00€1mL*10mM (DMSO)111,00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Forma y color:SolidPeso molecular:419.31GGTI298 Trifluoroacetate
CAS:GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Fórmula:C27H33N3O3S·C2HF3O2Pureza:100% - 98.29%Forma y color:SolidPeso molecular:593.66ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.81%Forma y color:SolidPeso molecular:430.84Ref: TM-T10376
1mg52,00€5mg117,00€10mg170,00€25mg325,00€50mg469,00€100mg615,00€1mL*10mM (DMSO)134,00€SOS2 ligand 1
CAS:SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Fórmula:C19H21N5OForma y color:SolidPeso molecular:335.403ML141
CAS:ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Fórmula:C22H21N3O3SPureza:99.36% - 99.56%Forma y color:SolidPeso molecular:407.49Ref: TM-T2463
1mg39,00€2mg50,00€5mg72,00€10mg110,00€25mg225,00€50mg406,00€100mg582,00€500mg1.254,00€1mL*10mM (DMSO)74,00€ESI-08
CAS:ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.Fórmula:C20H23N3OSPureza:99.05%Forma y color:SolidPeso molecular:353.48NSC 23766 trihydrochloride
CAS:NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Fórmula:C24H35N7·3HClPureza:96.48% - 99.54%Forma y color:SolidPeso molecular:530.96MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 98.74%Forma y color:SolidPeso molecular:338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Forma y color:SolidPeso molecular:541.61Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Forma y color:SolidPeso molecular:425.91Ref: TM-T9407
1mg40,00€5mg80,00€10mg116,00€25mg205,00€50mg340,00€100mg485,00€200mg655,00€1mL*10mM (DMSO)88,00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Forma y color:SolidPeso molecular:444.86Ref: TM-T7764
2mg42,00€5mg65,00€10mg99,00€25mg182,00€50mg279,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)70,00€6H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Forma y color:SolidPeso molecular:476.12KRAS inhibitor-32
CAS:KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Fórmula:C29H35FN10OS2Forma y color:SolidPeso molecular:622.78Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Fórmula:C32H35ClFN7O2Pureza:99.10% - 99.9%Forma y color:SolidPeso molecular:604.12LUNA18
CAS:LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation.Fórmula:C73H105F5N12O12Pureza:98%Forma y color:SolidPeso molecular:1437.68KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Forma y color:SolidPeso molecular:600.15NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Fórmula:C24H26N2O5Forma y color:SolidPeso molecular:422.47Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Fórmula:C19H18O8Pureza:98% - 99.57%Forma y color:SolidPeso molecular:374.34pan-KRAS degrader 1
CAS:Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Fórmula:C22H26N8OSForma y color:SolidPeso molecular:450.56BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Forma y color:SolidPeso molecular:334.3CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Forma y color:SolidPeso molecular:478.82Ref: TM-T22062
5mg38,00€10mg57,00€25mg114,00€50mg188,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)43,00€KRAS inhibitor-31
CAS:KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Fórmula:C33H30F3N5O4Forma y color:SolidPeso molecular:617.62CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.35%Forma y color:SolidPeso molecular:408.88MC 976
CAS:MC 976 is a derivative of Vitamin D3.Fórmula:C27H42O3Pureza:98%Forma y color:SolidPeso molecular:414.63BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.20% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Fórmula:C13H11F3N2OSForma y color:SolidPeso molecular:300.3Methylophiopogonanone B
CAS:1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.Fórmula:C19H20O5Pureza:99.24%Forma y color:SolidPeso molecular:328.36ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Fórmula:C26H24FNO5Pureza:97.75%Forma y color:SoildPeso molecular:449.47Ref: TM-T85316
1mg49,00€5mg92,00€10mg131,00€25mg212,00€50mg373,00€100mg635,00€200mg1.035,00€1mL*10mM (DMSO)110,00€Arglabin
CAS:Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Fórmula:C15H18O3Pureza:99.62% - 99.62%Forma y color:SolidPeso molecular:246.3Ref: TM-TQ0165
1mg104,00€5mg240,00€10mg360,00€25mg520,00€50mg692,00€100mg1.035,00€1mL*10mM (DMSO)310,00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24Ref: TM-T8870
1mg51,00€5mg153,00€10mg207,00€25mg288,00€50mg404,00€100mg562,00€200mg758,00€1mL*10mM (DMSO)101,00€KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Forma y color:SolidPeso molecular:586.13ARS-853
CAS:ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFórmula:C22H29ClN4O3Pureza:96.64% - 97.43%Forma y color:SolidPeso molecular:432.94Ref: TM-T7414
1mg150,00€5mg373,00€10mg553,00€25mg890,00€50mg1.206,00€100mg1.634,00€500mg3.258,00€1mL*10mM (DMSO)356,00€KRAS inhibitor-35
CAS:KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Fórmula:C38H32F4N6O3SForma y color:SolidPeso molecular:728.76pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Forma y color:SolidPeso molecular:587.63KRAS G12D inhibitor 26
CAS:KRAS G12D inhibitor 26 serves as a modulator of Kras and specifically targets Kras(G12D) with an IC50 of less than or equal to 100 nM.Fórmula:C35H44ClFN8O2Forma y color:SolidPeso molecular:663.228CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Fórmula:C18H13ClF6N2O3Pureza:99.80%Forma y color:SolidPeso molecular:454.75CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Forma y color:SolidPeso molecular:486.38Ref: TM-T8930
2mg35,00€5mg52,00€10mg89,00€25mg167,00€50mg258,00€100mg379,00€200mg540,00€1mL*10mM (DMSO)58,00€HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Fórmula:C19H21N3OSPureza:98.05%Forma y color:SolidPeso molecular:339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Fórmula:C24H20ClF2N3O3Pureza:98%Forma y color:SolidPeso molecular:471.88APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Fórmula:C23H16F8N4O3Pureza:99.39%Forma y color:SolidPeso molecular:548.39Ref: TM-T8843
2mg39,00€5mg88,00€10mg127,00€25mg250,00€50mg401,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)97,00€ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Fórmula:C14H13NO2SPureza:99.48%Forma y color:SolidPeso molecular:259.32Ref: TM-T22991
1mg48,00€2mg64,00€5mg96,00€10mg153,00€25mg305,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)94,00€KRas G12C inhibitor 2
CAS:KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Fórmula:C32H37N7O3Pureza:98%Forma y color:SolidPeso molecular:567.68SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Fórmula:C24H28N2O9SPureza:95.65%Forma y color:SolidPeso molecular:520.55pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Fórmula:C36H34F2N6O3Pureza:98%Forma y color:SolidPeso molecular:636.69KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Fórmula:C31H38N6O3Pureza:98%Forma y color:SolidPeso molecular:542.67Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Fórmula:C22H30O2SPureza:99.45%Forma y color:SolidPeso molecular:358.54Ref: TM-T6163
5mg35,00€10mg52,00€25mg96,00€50mg159,00€100mg221,00€200mg364,00€500mg597,00€1mL*10mM (DMSO)59,00€TH-Z827
CAS:TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Fórmula:C30H38N6OPureza:98%Forma y color:SolidPeso molecular:498.66KRAS inhibitor-6
CAS:KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Fórmula:C27H30ClF2N5O3Pureza:98%Forma y color:SolidPeso molecular:546.01KRAS G12C inhibitor 58
CAS:KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Fórmula:C51H64ClF4N9O8SPureza:98%Forma y color:SolidPeso molecular:1074.62Lonafarnib
CAS:Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).Fórmula:C27H31Br2ClN4O2Pureza:98% - 99.04%Forma y color:SolidPeso molecular:638.82KRAS G12C inhibitor 15
CAS:KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .Fórmula:C25H21ClF2N4O3Pureza:98%Forma y color:SolidPeso molecular:498.91ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:96.57%Forma y color:SolidPeso molecular:747.85pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFórmula:C34H34F2N4O3Pureza:98%Forma y color:SolidPeso molecular:584.66MRTX1133
CAS:View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.Fórmula:C33H31F3N6O2Pureza:97.39% - 99.10%Forma y color:SolidPeso molecular:600.63Ref: TM-T9303
1mg187,00€5mg399,00€10mg612,00€25mg944,00€50mg1.320,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)530,00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24%Forma y color:SolidPeso molecular:1019.25Sevelamer Carbonate
CAS:Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.Fórmula:(C3H7N·C3H5ClO)x·xCH2O3Pureza:98%Forma y color:SolidPeso molecular:211.64RBC8
CAS:RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Fórmula:C25H20N4O3Pureza:98.44% - 99.81%Forma y color:SolidPeso molecular:424.45Ref: TM-T6634
1mg48,00€5mg92,00€10mg156,00€25mg298,00€50mg472,00€100mg687,00€200mg938,00€1mL*10mM (DMSO)97,00€Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.06%Forma y color:SolidPeso molecular:603.75KRAS G12C inhibitor 32
CAS:KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Fórmula:C29H30Cl3FN6O3Pureza:98%Forma y color:SolidPeso molecular:635.94Pan-RAS-IN-1
CAS:Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Fórmula:C36H41Cl2F3N6O2Pureza:98.57%Forma y color:SolidPeso molecular:717.65Ref: TM-T16432
1mg80,00€2mg97,00€5mg144,00€10mg216,00€25mg439,00€50mg660,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)221,00€SOS1-IN-16
CAS:SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFórmula:C30H31F3N4O3Pureza:98%Forma y color:SolidPeso molecular:552.59KRAS inhibitor-8
CAS:KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Fórmula:C26H24ClF4N5O3Pureza:98%Forma y color:SolidPeso molecular:565.95KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Fórmula:C32H37N7O2Pureza:98%Forma y color:SolidPeso molecular:551.68KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Fórmula:C18H17ClFN3O4SPureza:98%Forma y color:SolidPeso molecular:425.86ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93KRAS inhibitor-37
CAS:KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.Fórmula:C32H33ClFN7O3Forma y color:SolidPeso molecular:618.10ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5PROTAC K-Ras Degrader-3
CAS:PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Fórmula:C57H67F2N9O6Forma y color:SolidPeso molecular:1012.20RGT-018
CAS:RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.Fórmula:C27H24F3N7O2Forma y color:SolidPeso molecular:535.52J-104871
CAS:J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.Fórmula:C38H32N2O12Pureza:98%Forma y color:SolidPeso molecular:708.67KRAS inhibitor-7
CAS:KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Fórmula:C26H27ClF2N6O2Pureza:98%Forma y color:SolidPeso molecular:528.98ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Fórmula:C19H19NO3Pureza:99.06% - 99.52%Forma y color:SolidPeso molecular:309.36Ref: TM-T4619
1mg39,00€2mg49,00€5mg70,00€10mg99,00€25mg200,00€50mg283,00€100mg394,00€500mg934,00€1mL*10mM (DMSO)88,00€Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFórmula:C31H26ClF4N7O2Pureza:100% - 100%Forma y color:SolidPeso molecular:640.03pan-KRAS-IN-17
CAS:pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Fórmula:C34H33F3N5O8PForma y color:SolidPeso molecular:727.623MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Fórmula:C22H21N3Forma y color:SolidPeso molecular:327.42XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Fórmula:C21H21ClN4OPureza:97.51%Forma y color:SolidPeso molecular:380.87SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Fórmula:C22H24F3N5OPureza:98.79%Forma y color:SolidPeso molecular:431.45Ref: TM-T60029
1mg75,00€5mg169,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€1mL*10mM (DMSO)180,00€BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Fórmula:C31H28N6O2Pureza:98.98%Forma y color:SolidPeso molecular:516.59Ref: TM-T10533
1mg116,00€5mg276,00€10mg410,00€25mg680,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)314,00€Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Forma y color:SolidPeso molecular:565.43Phellodendrine chloride
CAS:Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Fórmula:C20H24ClNO4Pureza:98.85% - 99.05%Forma y color:SolidPeso molecular:377.86AMG410
CAS:AMG410 is a non-covalent, bimodal GDP (OFF) and GTP (ON)-binding pan-KRAS inhibitor , binds on the variegated pocket, in KRAS G12D, G12V, G12C, G13D.Fórmula:C31H32ClF2N7O5Forma y color:SoildPeso molecular:656.08AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Fórmula:C24H16FN3OS2Forma y color:SolidPeso molecular:445.53KRAS G12D inhibitor 25
CAS:KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Fórmula:C56H62ClN11O6Forma y color:SolidPeso molecular:1020.62ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Forma y color:SolidPeso molecular:584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€KRAS inhibitor-34
CAS:KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.Fórmula:C43H41F3N6O3Forma y color:SolidPeso molecular:746.82ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Fórmula:C21H17ClF2N4O2Pureza:98.86%Forma y color:SolidPeso molecular:430.84Ref: TM-T7609
1mg92,00€2mg117,00€5mg188,00€10mg274,00€25mg543,00€50mg780,00€100mg938,00€1mL*10mM (DMSO)212,00€K-Ras(G12C) inhibitor 12
CAS:K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C15H17ClIN3O3Pureza:97.16%Forma y color:SolidPeso molecular:449.67MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:96.59% - 99.07%Forma y color:SolidPeso molecular:565.71Ref: TM-T16143
1mg64,00€2mg89,00€5mg131,00€10mg220,00€25mg371,00€50mg557,00€100mg797,00€1mL*10mM (DMSO)170,00€Kobe0065
CAS:Kobe0065: novel small-molecule, inhibits Ras-Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Fórmula:C15H11ClF3N5O4SPureza:100% - 99.58%Forma y color:SolidPeso molecular:449.79BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:96.8%Forma y color:SolidPeso molecular:448.586H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Fórmula:C22H31ClF3N3O4S3Pureza:≥95%Forma y color:SolidPeso molecular:590.14Ref: TM-T7326
1mg69,00€2mg95,00€5mg134,00€10mg230,00€25mg378,00€50mg568,00€100mg807,00€1mL*10mM (DMSO)170,00€TH-Z835
CAS:TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.Fórmula:C30H38N6OPureza:98%Forma y color:SolidPeso molecular:498.66RMC-6236
CAS:RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.92%Forma y color:SolidPeso molecular:811.05K-Ras(G12C) Inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Forma y color:SolidPeso molecular:405.33Ref: TM-T3725
1mg63,00€2mg88,00€5mg133,00€10mg230,00€25mg477,00€50mg667,00€100mg932,00€1mL*10mM (DMSO)133,00€BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Fórmula:C47H62N8O4SForma y color:SolidPeso molecular:835.11MLS000532223
CAS:MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Fórmula:C15H9NO3Pureza:98.60%Forma y color:SolidPeso molecular:251.24Ref: TM-T8473
1mg130,00€2mg183,00€5mg306,00€10mg462,00€25mg755,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)319,00€1A-116
CAS:1A-116 is a specific Rac1 inhibitor.Fórmula:C16H16F3N3Pureza:98.43%Forma y color:SolidPeso molecular:307.31Ref: TM-T14004
1mg50,00€5mg111,00€10mg166,00€25mg283,00€50mg444,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)123,00€(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:98.01% - 99.76%Forma y color:SolidPeso molecular:560.59Ref: TM-T22258
2mg37,00€5mg52,00€10mg85,00€25mg156,00€50mg274,00€100mg426,00€500mg938,00€1mL*10mM (DMSO)77,00€
